AutismKB 2.0

Annotation Details for SLC7A11


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Basic Information Top
Gene Symbol:SLC7A11 ( CCBR1,xCT )
Gene Full Name: solute carrier family 7, (cationic amino acid transporter, y+ system) member 11
Band: 4q28.3
Quick LinksEntrez ID:23657; OMIM: 607933; Uniprot ID:XCT_HUMAN; ENSEMBL ID: ENSG00000151012; HGNC ID: 11059
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005791IEA-rough endoplasmic reticulum-
GO:0005856IEA-cytoskeleton-
GO:0005886TAS-plasma membrane-
GO:0005887IBA-integral component of plasma membrane-
GO:0009986IDA-cell surface25063885
GO:0016021TAS-integral component of membrane10206947
GO ID Evidence Qualifier GO_term References
GO:0005515IPI-protein binding21397861
GO:0015327TAS-cystine:glutamate antiporter activity10206947
GO ID Evidence Qualifier GO_term References
GO:0006865TAS-amino acid transport-
GO:0006979IEA-response to oxidative stress-
GO:0007420IEA-brain development-
GO:0009636IDA-response to toxic substance17575980
GO:0035094IEA-response to nicotine-
GO:0050900TAS-leukocyte migration-
GO:0070306IEA-lens fiber cell differentiation-
GO:0070527IEA-platelet aggregation-
GO:0089711IEA-L-glutamate transmembrane transport-
Protein-Protein Interaction Top
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1347355
  • Data Attributes: MGI curated and HomoloGene calculated
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018