AutismKB 2.0

Annotation Details for CADM1


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Basic Information Top
Gene Symbol:CADM1 ( BL2,DKFZp686F1789,IGSF4,IGSF4A,MGC149785,MGC51880,NECL2,Necl-2,RA175,ST17,SYNCAM,TSLC1,sTSLC-1,sgIGSF,synCAM1 )
Gene Full Name: cell adhesion molecule 1
Band: 11q23.3
Quick LinksEntrez ID:23705; OMIM: 605686; Uniprot ID:CADM1_HUMAN; ENSEMBL ID: ENSG00000182985; HGNC ID: 5951
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005886IDA-plasma membrane15811952
GO:0005886TAS-plasma membrane-
GO:0005887IBA-integral component of plasma membrane-
GO:0005911ISS-cell-cell junction12826663
GO:0005913IBA-cell-cell adherens junction-
GO:0016323ISS-basolateral plasma membrane12826663
GO:0045202IEA-synapse-
GO:0070062IDA-extracellular exosome23376485
GO ID Evidence Qualifier GO_term References
GO:0004872IBA-receptor activity-
GO:0005102IPI-receptor binding15811952
GO:0005102ISS-receptor binding12826663
GO:0005515IPI-protein binding12234973
GO:0030165ISS-PDZ domain binding12826663
GO:0042803IBA-protein homodimerization activity-
GO:0042803ISS-protein homodimerization activity12826663
GO:0050839IBA-cell adhesion molecule binding-
GO ID Evidence Qualifier GO_term References
GO:0001913IDANOTT cell mediated cytotoxicity15811952
GO:0006915IEA-apoptotic process-
GO:0007156IBA-homophilic cell adhesion via plasma membrane adhesion molecules-
GO:0007156ISS-homophilic cell adhesion via plasma membrane adhesion molecules12826663
GO:0007157IBA-heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules-
GO:0007157ISS-heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules12826663
GO:0007275IEA-multicellular organism development-
GO:0007283IEA-spermatogenesis-
GO:0008037IDA-cell recognition15811952
GO:0008037ISS-cell recognition12826663
GO:0030154IEA-cell differentiation-
GO:0034332TAS-adherens junction organization-
GO:0042271IDA-susceptibility to natural killer cell mediated cytotoxicity15811952
GO:0042271ISS-susceptibility to natural killer cell mediated cytotoxicity12826663
GO:0045954IDA-positive regulation of natural killer cell mediated cytotoxicity15811952
GO:0045954ISS-positive regulation of natural killer cell mediated cytotoxicity12826663
GO:0050715IDA-positive regulation of cytokine secretion15811952
GO:0050798IDANOTactivated T cell proliferation15811952
GO:0051606IDA-detection of stimulus15811952
GO:0051606ISS-detection of stimulus12826663
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
CADM1MPP311721813679854 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
CADM1MPP311049613679854 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
CADM1EPB41L311675312234973 Affinity Capture-Western; Reconstituted Complex
CADM1EPB41L311721812234973 Affinity Capture-Western; Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1889272
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018