AutismKB 2.0

Annotation Details for FLRT3


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Basic Information Top
Gene Symbol:FLRT3 ( - )
Gene Full Name: fibronectin leucine rich transmembrane protein 3
Band: 20p12.1
Quick LinksEntrez ID:23767; OMIM: 604808; Uniprot ID:FLRT3_HUMAN; ENSEMBL ID: ENSG00000125848; HGNC ID: 3762
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005578NAS-proteinaceous extracellular matrix10644439
GO:0005615IEA-extracellular space-
GO:0005737IBA-cytoplasm-
GO:0005789IEA-endoplasmic reticulum membrane-
GO:0005886TAS-plasma membrane-
GO:0005887IDA-integral component of plasma membrane14706654
GO:0005887NAS-integral component of plasma membrane10644439
GO:0005911IEA-cell-cell junction-
GO:0005925IEA-focal adhesion-
GO:0043679ISS-axon terminus-
GO:0044295ISS-axonal growth cone-
GO:0097060ISS-synaptic membrane-
GO ID Evidence Qualifier GO_term References
GO:0004860IBA-protein kinase inhibitor activity-
GO:0005057NAS-signal transducer activity, downstream of receptor10644439
GO:0005104IEA-fibroblast growth factor receptor binding-
GO:0005515IPI-protein binding26235030
GO:0030674NAS-protein binding, bridging10644439
GO:0042803IDA-protein homodimerization activity26235030
GO:0045499IEA-chemorepellent activity-
GO ID Evidence Qualifier GO_term References
GO:0003345ISS-proepicardium cell migration involved in pericardium morphogenesis-
GO:0006469IBA-negative regulation of protein kinase activity-
GO:0007411IEA-axon guidance-
GO:0007416ISS-synapse assembly-
GO:0007507ISS-heart development-
GO:0008543ISS-fibroblast growth factor receptor signaling pathway-
GO:0008543TAS-fibroblast growth factor receptor signaling pathway-
GO:0019221IBA-cytokine-mediated signaling pathway-
GO:0031175ISS-neuron projection development-
GO:0046426IBA-negative regulation of JAK-STAT cascade-
GO:0048598ISS-embryonic morphogenesis-
GO:0048678ISS-response to axon injury-
GO:0050919IEA-negative chemotaxis-
GO:0051965IEA-positive regulation of synapse assembly-
GO:0060322ISS-head development-
GO:0098742IDA-cell-cell adhesion via plasma-membrane adhesion molecules26235030
GO:1990138IMP-neuron projection extension14706654
GO:1990138ISS-neuron projection extension-
Protein-Protein Interaction Top
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1918686
  • Data Attributes: MGI curated and HomoloGene calculated
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018