AutismKB 2.0

Annotation Details for FLRT2


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Basic Information Top
Gene Symbol:FLRT2 ( KIAA0405 )
Gene Full Name: fibronectin leucine rich transmembrane protein 2
Band: 14q31.3
Quick LinksEntrez ID:23768; OMIM: 604807; Uniprot ID:FLRT2_HUMAN; ENSEMBL ID: ENSG00000185070; HGNC ID: 3761
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005578NAS-proteinaceous extracellular matrix10644439
GO:0005615IEA-extracellular space-
GO:0005737IBA-cytoplasm-
GO:0005789IEA-endoplasmic reticulum membrane-
GO:0005886TAS-plasma membrane-
GO:0005887ISS-integral component of plasma membrane-
GO:0005887NAS-integral component of plasma membrane10644439
GO:0005911ISS-cell-cell junction-
GO:0005925IDA-focal adhesion21423176
GO:0005925ISScolocalizes_withfocal adhesion-
GO:0031090IEA-organelle membrane-
GO:0043005IEA-neuron projection-
GO:0045202IEA-synapse-
GO:0070062IDA-extracellular exosome23376485
GO ID Evidence Qualifier GO_term References
GO:0004860IBA-protein kinase inhibitor activity-
GO:0005057NAS-signal transducer activity, downstream of receptor10644439
GO:0005104IEA-fibroblast growth factor receptor binding-
GO:0030674NAS-protein binding, bridging10644439
GO:0045499IEA-chemorepellent activity-
GO ID Evidence Qualifier GO_term References
GO:0003007ISS-heart morphogenesis-
GO:0006469IBA-negative regulation of protein kinase activity-
GO:0007411IEA-axon guidance-
GO:0008150ND-biological_process-
GO:0008543ISS-fibroblast growth factor receptor signaling pathway-
GO:0008543TAS-fibroblast growth factor receptor signaling pathway-
GO:0019221IBA-cytokine-mediated signaling pathway-
GO:0046426IBA-negative regulation of JAK-STAT cascade-
GO:0050919IEA-negative chemotaxis-
GO:0051965IEA-positive regulation of synapse assembly-
GO:0061343ISS-cell adhesion involved in heart morphogenesis-
GO:0071711ISS-basement membrane organization-
GO:2001222IEA-regulation of neuron migration-
Protein-Protein Interaction Top
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:3603594
  • Data Attributes: MGI curated and HomoloGene calculated
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018