Gene Symbol:	ALOX12 ( 12-LOX,12S-LOX,LOG12 )
Gene Full Name:	arachidonate 12-lipoxygenase
Band:	17p13.1
Quick Links	Entrez ID:239; OMIM: 152391; Uniprot ID:LOX12_HUMAN; ENSEMBL ID: ENSG00000108839; HGNC ID: 429
Relate to Another Database:	SFARIGene; denovo-db

GO ID	Evidence	Qualifier	GO_term	References
GO:0005737	IDA	-	cytoplasm	8319693
GO:0005829	IDA	-	cytosol	8912711
GO:0005829	TAS	-	cytosol	-
GO:0016020	IDA	-	membrane	8912711
GO:0042383	IDA	-	sarcolemma	15107407
GO:0070062	IDA	-	extracellular exosome	19056867

GO ID	Evidence	Qualifier	GO_term	References
GO:0004052	IDA	-	arachidonate 12-lipoxygenase activity	1851637
GO:0004052	TAS	-	arachidonate 12-lipoxygenase activity	-
GO:0005506	IEA	-	iron ion binding	-
GO:0005515	IPI	-	protein binding	10727209
GO:0016165	IDA	-	linoleate 13S-lipoxygenase activity	8319693
GO:0016702	TAS	-	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	-
GO:0047977	ISS	-	hepoxilin-epoxide hydrolase activity	-
GO:0051120	TAS	-	hepoxilin A3 synthase activity	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0006928	IMP	-	movement of cell or subcellular component	14669797
GO:0007568	IEA	-	aging	-
GO:0008284	IMP	-	positive regulation of cell proliferation	9751607
GO:0008284	ISS	-	positive regulation of cell proliferation	-
GO:0010595	IEA	-	positive regulation of endothelial cell migration	-
GO:0010628	IEA	-	positive regulation of gene expression	-
GO:0010656	IMP	-	negative regulation of muscle cell apoptotic process	23578768
GO:0019369	IDA	-	arachidonic acid metabolic process	1851637
GO:0019369	ISS	-	arachidonic acid metabolic process	-
GO:0019372	IDA	-	lipoxygenase pathway	8319693
GO:0019372	TAS	-	lipoxygenase pathway	-
GO:0019395	IMP	-	fatty acid oxidation	15111312
GO:0030307	IMP	-	positive regulation of cell growth	14767568
GO:0030335	IMP	-	positive regulation of cell migration	22237009
GO:0042554	NAS	-	superoxide anion generation	15107407
GO:0043066	IMP	-	negative regulation of apoptotic process	15305153
GO:0043066	ISS	-	negative regulation of apoptotic process	-
GO:0043280	IEA	-	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	-
GO:0043651	IDA	-	linoleic acid metabolic process	8319693
GO:0043651	IDA	NOT	linoleic acid metabolic process	1851637
GO:0045603	IEA	-	positive regulation of endothelial cell differentiation	-
GO:0045766	IMP	-	positive regulation of angiogenesis	9751607
GO:0045785	IMP	-	positive regulation of cell adhesion	14669797
GO:0048661	IEA	-	positive regulation of smooth muscle cell proliferation	-
GO:0051121	TAS	-	hepoxilin metabolic process	-
GO:0051122	ISS	-	hepoxilin biosynthetic process	-
GO:0051901	IEA	-	positive regulation of mitochondrial depolarization	-
GO:0061436	ISS	-	establishment of skin barrier	-
GO:0071396	IEA	-	cellular response to lipid	-
GO:0072593	NAS	-	reactive oxygen species metabolic process	12858336
GO:0090331	ISS	-	negative regulation of platelet aggregation	-
GO:0097755	IEA	-	positive regulation of blood vessel diameter	-
GO:1901751	IDA	-	leukotriene A4 metabolic process	8250832
GO:1901751	IDA	NOT	leukotriene A4 metabolic process	1851637
GO:2001300	TAS	-	lipoxin metabolic process	-
GO:2001303	IDA	-	lipoxin A4 biosynthetic process	8250832
GO:2001306	IDA	-	lipoxin B4 biosynthetic process	8250832

Gene Symbol	Interactant	Interaction ID	References	Description
KRT5	ALOX12	110050	10727209	Affinity Capture-Western; Two-hybrid
KRT5	ALOX12	106740	10727209	Affinity Capture-Western; Two-hybrid
LMNA	ALOX12	110186	10727209	Affinity Capture-Western; Two-hybrid
LMNA	ALOX12	106740	10727209	Affinity Capture-Western; Two-hybrid
TRIB1	ALOX12	115516	10727209	Two-hybrid
TRIB1	ALOX12	106740	10727209	Two-hybrid
ITGB4	ALOX12	109897	10727209	Two-hybrid
ITGB4	ALOX12	106740	10727209	Two-hybrid

AutismKB 2.0

Annotation Details for ALOX12

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