AutismKB 2.0

Annotation Details for ALOX5


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Basic Information Top
Gene Symbol:ALOX5 ( 5-LO,5-LOX,5LPG,LOG5,MGC163204 )
Gene Full Name: arachidonate 5-lipoxygenase
Band: 10q11.21
Quick LinksEntrez ID:240; OMIM: 152390; Uniprot ID:LOX5_HUMAN; ENSEMBL ID: ENSG00000012779; HGNC ID: 435
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576TAS-extracellular region-
GO:0005615IDA-extracellular space22664934
GO:0005635IDA-nuclear envelope19233132
GO:0005635TAS-nuclear envelope-
GO:0005641IDA-nuclear envelope lumen8245774
GO:0005654IDA-nucleoplasm-
GO:0005829IDA-cytosol19233132
GO:0005829TAS-cytosol-
GO:0016363IDA-nuclear matrix19233132
GO:0031965IDA-nuclear membrane8245774
GO:0034774TAS-secretory granule lumen-
GO:1904813TAS-ficolin-1-rich granule lumen-
GO ID Evidence Qualifier GO_term References
GO:0004051IDA-arachidonate 5-lipoxygenase activity21233389
GO:0005506IDA-iron ion binding21233389
GO:0005515IPI-protein binding11297527
GO ID Evidence Qualifier GO_term References
GO:0002540IEA-leukotriene production involved in inflammatory response-
GO:0006691TAS-leukotriene metabolic process-
GO:0019370IDA-leukotriene biosynthetic process21233389
GO:0019372TAS-lipoxygenase pathway-
GO:0043312TAS-neutrophil degranulation-
GO:0055114IEA-oxidation-reduction process-
GO:2001300TAS-lipoxin metabolic process-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
GRB2ALOX51067417929073 8585605 Reconstituted Complex
GRB2ALOX51091427929073 8585605 Reconstituted Complex
COTL1P1ALOX510674110051563 Two-hybrid
COTL1P1ALOX511804910051563 Two-hybrid
TGFBRAP1ALOX511479210051563 Two-hybrid
TGFBRAP1ALOX510674110051563 Two-hybrid
COTL1ALOX511697911297527 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
COTL1ALOX510674111297527 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
ALOX5ALOX5−1708G/A, ALOX5−1761G/A, ALOX5_VNTR, ALOX5_unknown Gene overview in AlzGene
No data
No data
Animal Model Top
  • MGI ID: MGI:87999
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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