AutismKB 2.0

Annotation Details for FRK


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Basic Information Top
Gene Symbol:FRK ( GTK,PTK5,RAK )
Gene Full Name: fyn-related kinase
Band: 6q22.1
Quick LinksEntrez ID:2444; OMIM: 606573; Uniprot ID:FRK_HUMAN; ENSEMBL ID: ENSG00000111816; HGNC ID: 3955
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576TAS-extracellular region-
GO:0005622TAS-intracellular7510261
GO:0005634TAS-nucleus7696183
GO:0005654IDA-nucleoplasm-
GO:0005829IDA-cytosol-
GO:0031234IBA-extrinsic component of cytoplasmic side of plasma membrane-
GO:0035578TAS-azurophil granule lumen-
GO:0035580TAS-specific granule lumen-
GO:0070062IDA-extracellular exosome19056867
GO ID Evidence Qualifier GO_term References
GO:0004715IBA-non-membrane spanning protein tyrosine kinase activity-
GO:0005102IBA-receptor binding-
GO:0005515IPI-protein binding7664264
GO:0005524IEA-ATP binding-
GO ID Evidence Qualifier GO_term References
GO:0000122IDA-negative regulation of transcription from RNA polymerase II promoter12837246
GO:0006468TAS-protein phosphorylation7696183
GO:0007169IBA-transmembrane receptor protein tyrosine kinase signaling pathway-
GO:0008285TAS-negative regulation of cell proliferation7664264
GO:0016477IBA-cell migration-
GO:0030154IBA-cell differentiation-
GO:0038083IBA-peptidyl-tyrosine autophosphorylation-
GO:0043312TAS-neutrophil degranulation-
GO:0045087IBA-innate immune response-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
RB1FRK1087267664264 Affinity Capture-Western; Reconstituted Complex
RB1FRK1118607664264 Affinity Capture-Western; Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:103265
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018