AutismKB 2.0

Annotation Details for MTOR


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Basic Information Top
Gene Symbol:MTOR ( FLJ44809,FRAP,FRAP1,FRAP2,RAFT1,RAPT1 )
Gene Full Name: mechanistic target of rapamycin (serine/threonine kinase)
Band: 1p36.22
Quick LinksEntrez ID:2475; OMIM: 601231; Uniprot ID:MTOR_HUMAN; ENSEMBL ID: ENSG00000198793; HGNC ID: 3942
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000139IEA-Golgi membrane-
GO:0005654TAS-nucleoplasm-
GO:0005737IDA-cytoplasm11853878
GO:0005741IEA-mitochondrial outer membrane-
GO:0005764IDA-lysosome20381137
GO:0005764IMP-lysosome22424946
GO:0005765IDA-lysosomal membrane17897319
GO:0005789IEA-endoplasmic reticulum membrane-
GO:0005829TAS-cytosol-
GO:0005942NAS-phosphatidylinositol 3-kinase complex15539461
GO:0012505IDA-endomembrane system18497260
GO:0016020IDA-membrane11853878
GO:0016605ISScolocalizes_withPML body-
GO:0030425IEA-dendrite-
GO:0031931IDA-TORC1 complex12150926
GO:0031931IMP-TORC1 complex20537536
GO:0031932IDA-TORC2 complex15467718
GO:0043025IEA-neuronal cell body-
GO ID Evidence Qualifier GO_term References
GO:0001030IDA-RNA polymerase III type 1 promoter DNA binding20233713
GO:0001031IDA-RNA polymerase III type 2 promoter DNA binding20233713
GO:0001032IDA-RNA polymerase III type 3 promoter DNA binding20233713
GO:0001156IDA-TFIIIC-class transcription factor binding20543138
GO:0004672IDA-protein kinase activity12150926
GO:0004674EXP-protein serine/threonine kinase activity22768106
GO:0004674IDA-protein serine/threonine kinase activity12718876
GO:0004674TAS-protein serine/threonine kinase activity-
GO:0005515IPI-protein binding10089303
GO:0005524IEA-ATP binding-
GO:0016301IDA-kinase activity15467718
GO:0016301TAS-kinase activity11853878
GO:0019901IEA-protein kinase binding-
GO:0019904IEA-protein domain specific binding-
GO:0043022IEA-ribosome binding-
GO:0051219IPI-phosphoprotein binding11853878
GO ID Evidence Qualifier GO_term References
GO:0001933IEA-negative regulation of protein phosphorylation-
GO:0001934IDA-positive regulation of protein phosphorylation20233713
GO:0001938IEA-positive regulation of endothelial cell proliferation-
GO:0003007IEA-heart morphogenesis-
GO:0003179IEA-heart valve morphogenesis-
GO:0005979IEA-regulation of glycogen biosynthetic process-
GO:0006112IEA-energy reserve metabolic process-
GO:0006207IEA-'de novo' pyrimidine nucleobase biosynthetic process-
GO:0006468IDA-protein phosphorylation12150926
GO:0006468IMP-protein phosphorylation17028174
GO:0006950IMP-response to stress17028174
GO:0007050TAS-cell cycle arrest-
GO:0007165NAS-signal transduction15539461
GO:0007281IEA-germ cell development-
GO:0007420IEA-brain development-
GO:0007569IEA-cell aging-
GO:0007584NAS-response to nutrient15539461
GO:0007616IEA-long-term memory-
GO:0008361IMP-regulation of cell size22424946
GO:0008542IEA-visual learning-
GO:0009791IEA-post-embryonic development-
GO:0010507IMP-negative regulation of autophagy22424946
GO:0010507ISS-negative regulation of autophagy-
GO:0010592IEA-positive regulation of lamellipodium assembly-
GO:0010628IMP-positive regulation of gene expression17028174
GO:0010718IMP-positive regulation of epithelial to mesenchymal transition27919618
GO:0010831IEA-positive regulation of myotube differentiation-
GO:0014042IEA-positive regulation of neuron maturation-
GO:0014736IEA-negative regulation of muscle atrophy-
GO:0016049IDA-cell growth18762023
GO:0016049TAS-cell growth11853878
GO:0016241TAS-regulation of macroautophagy-
GO:0016242IDA-negative regulation of macroautophagy25327288
GO:0016310IDA-phosphorylation11853878
GO:0018105IMP-peptidyl-serine phosphorylation20537536
GO:0018107IEA-peptidyl-threonine phosphorylation-
GO:0021510IEA-spinal cord development-
GO:0030163TAS-protein catabolic process11853878
GO:0030838IEA-positive regulation of actin filament polymerization-
GO:0031295TAS-T cell costimulation-
GO:0031397IEA-negative regulation of protein ubiquitination-
GO:0031529IEA-ruffle organization-
GO:0031641IEA-regulation of myelination-
GO:0031669ISS-cellular response to nutrient levels-
GO:0031929IMP-TOR signaling15467718
GO:0031929NAS-TOR signaling23778976
GO:0031998IEA-regulation of fatty acid beta-oxidation-
GO:0032095IEA-regulation of response to food-
GO:0032868IEA-response to insulin-
GO:0032956IMP-regulation of actin cytoskeleton organization15467718
GO:0034198IDA-cellular response to amino acid starvation22424946
GO:0035176IEA-social behavior-
GO:0035264IEA-multicellular organism growth-
GO:0038202IMP-TORC1 signaling12718876
GO:0040007NAS-growth15539461
GO:0042060IEA-wound healing-
GO:0042220IEA-response to cocaine-
GO:0043087IEA-regulation of GTPase activity-
GO:0043200IDA-response to amino acid18497260
GO:0043276NAS-anoikis23778976
GO:0043278IEA-response to morphine-
GO:0043610IEA-regulation of carbohydrate utilization-
GO:0045429IEA-positive regulation of nitric oxide biosynthetic process-
GO:0045670ISS-regulation of osteoclast differentiation-
GO:0045727IDA-positive regulation of translation18762023
GO:0045792IEA-negative regulation of cell size-
GO:0045859IEA-regulation of protein kinase activity-
GO:0045945IMP-positive regulation of transcription from RNA polymerase III promoter20233713
GO:0046777IDA-protein autophosphorylation15467718
GO:0046889IMP-positive regulation of lipid biosynthetic process18762023
GO:0048015TAS-phosphatidylinositol-mediated signaling-
GO:0048255IEA-mRNA stabilization-
GO:0048661IEA-positive regulation of smooth muscle cell proliferation-
GO:0048714IEA-positive regulation of oligodendrocyte differentiation-
GO:0050731IEA-positive regulation of peptidyl-tyrosine phosphorylation-
GO:0050882IEA-voluntary musculoskeletal movement-
GO:0051496IEA-positive regulation of stress fiber assembly-
GO:0051534IEA-negative regulation of NFAT protein import into nucleus-
GO:0051549IMP-positive regulation of keratinocyte migration27919618
GO:0051897IEA-positive regulation of protein kinase B signaling-
GO:0055013IEA-cardiac muscle cell development-
GO:0060048IEA-cardiac muscle contraction-
GO:0060135IEA-maternal process involved in female pregnancy-
GO:0060252IEA-positive regulation of glial cell proliferation-
GO:0060999IEA-positive regulation of dendritic spine development-
GO:0061051IEA-positive regulation of cell growth involved in cardiac muscle cell development-
GO:0071230IDA-cellular response to amino acid stimulus22424946
GO:0071233IDA-cellular response to leucine22424946
GO:0071456ISS-cellular response to hypoxia-
GO:0090335IEA-regulation of brown fat cell differentiation-
GO:0090559IEA-regulation of membrane permeability-
GO:1900034TAS-regulation of cellular response to heat-
GO:1901216IEA-positive regulation of neuron death-
GO:1901838IMP-positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter24036451
GO:1903691IMP-positive regulation of wound healing, spreading of epidermal cells27919618
GO:1904000IEA-positive regulation of eating behavior-
GO:1904056IEA-positive regulation of cholangiocyte proliferation-
GO:1904058IEA-positive regulation of sensory perception of pain-
GO:1904193IEA-negative regulation of cholangiocyte apoptotic process-
GO:1904197IEA-positive regulation of granulosa cell proliferation-
GO:1904206IEA-positive regulation of skeletal muscle hypertrophy-
GO:1904213IEA-negative regulation of iodide transmembrane transport-
GO:1990253IDA-cellular response to leucine starvation22424946
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
MTORABL110654310753870 Affinity Capture-Western
MTORABL110875710753870 Affinity Capture-Western
MTORAKT110671010910062 14970221 15718470 Protein-peptide; Reconstituted Complex
MTORAKT110875710910062 14970221 15718470 Protein-peptide; Reconstituted Complex
MTOREIF4EBP11087579465032 10971657 12150925 12150926 12747827 15767663 15854902 16798736 Affinity Capture-Western; Reconstituted Complex
MTOREIF4EBP11082939465032 10971657 12150925 12150926 12747827 15767663 15854902 16798736 Affinity Capture-Western; Reconstituted Complex
MTORFKBP1A1085707822316 8662507 15268862 15284440 15467718 15796538 Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex; Two-hybrid
MTORFKBP1A1087577822316 8662507 15268862 15284440 15467718 15796538 Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex; Two-hybrid
RPS6KB1MTOR1121129465032 10567431 10971657 11914378 12150925 12150926 12604610 14679009 15809305 15854902 15896331 15899889 15905173 16183647 16922504 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
RPS6KB1MTOR1087579465032 10567431 10971657 11914378 12150925 12150926 12604610 14679009 15809305 15854902 15896331 15899889 15905173 16183647 16922504 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
PPP2R2AMTOR11151210200280 Reconstituted Complex
PPP2R2AMTOR10875710200280 Reconstituted Complex
GPHNMTOR10875710325225 Affinity Capture-Western; Reconstituted Complex
GPHNMTOR11553710325225 Affinity Capture-Western; Reconstituted Complex
PDK1MTOR11118910567431 Phenotypic Enhancement
PDK1MTOR10875710567431 Phenotypic Enhancement
STAT3MTOR10875710660304 15522880 Affinity Capture-Western; Reconstituted Complex
STAT3MTOR11265110660304 15522880 Affinity Capture-Western; Reconstituted Complex
PRKCDMTOR11156610698949 Affinity Capture-Western
PRKCDMTOR10875710698949 Affinity Capture-Western
GDI2P1MTOR10875711287630 Affinity Capture-Western
GDI2P1MTOR10893511287630 Affinity Capture-Western
IRS1MTOR10875711287630 Affinity Capture-Western
IRS1MTOR10987411287630 Affinity Capture-Western
CFPMTOR10875711733037 Reconstituted Complex
CFPMTOR11122211733037 Reconstituted Complex
UBQLN1MTOR10875711853878 Affinity Capture-Western; Two-hybrid
UBQLN1MTOR11900711853878 Affinity Capture-Western; Two-hybrid
RPTORMTOR10875712150925 12150926 12604610 12665511 12719976 12747827 15066126 15268862 15459249 15467718 16183647 16354680 16603397 16631613 16798736 16837165 16847060 16919458 16962653 17043309 20427287 Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
RPTORMTOR12158212150925 12150926 12604610 12665511 12719976 12747827 15066126 15268862 15459249 15467718 16183647 16354680 16603397 16631613 16798736 16837165 16847060 16919458 16962653 17043309 20427287 Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
CLIP1MTOR11216312231510 Affinity Capture-Western; Reconstituted Complex
CLIP1MTOR10875712231510 Affinity Capture-Western; Reconstituted Complex
MLST8MTOR10875712719976 15066126 16183647 20427287 20562859 Affinity Capture-MS; Affinity Capture-Western
MLST8MTOR12211312719976 15066126 16183647 20427287 20562859 Affinity Capture-MS; Affinity Capture-Western
STAT1MTOR10875712807916 Affinity Capture-Western
STAT1MTOR11264912807916 Affinity Capture-Western
PRKAA1MTOR11154914970221 Protein-peptide
PRKAA1MTOR10875714970221 Protein-peptide
RICTORMTOR10875715268862 15467718 16183647 16603397 16919458 16962653 17043309 20427287 Affinity Capture-MS; Affinity Capture-Western
RICTORMTOR12896215268862 15467718 16183647 16603397 16919458 16962653 17043309 20427287 Affinity Capture-MS; Affinity Capture-Western
RHEBMTOR10875715772076 15854902 15878852 16915281 Affinity Capture-Western; Reconstituted Complex
RHEBMTOR11194115772076 15854902 15878852 16915281 Affinity Capture-Western; Reconstituted Complex
TERTMTOR10875715843522 Affinity Capture-Western
TERTMTOR11287415843522 Affinity Capture-Western
RAP1AMTOR11184115854902 Affinity Capture-Western
RAP1AMTOR10875715854902 Affinity Capture-Western
PA2G4MTOR11107515896331 Reconstituted Complex
PA2G4MTOR10875715896331 Reconstituted Complex
EIF3BMTOR10875716286006 Affinity Capture-Western
EIF3BMTOR11421116286006 Affinity Capture-Western
EIF3CMTOR10875716286006 Affinity Capture-Western
EIF3CMTOR11421216286006 Affinity Capture-Western
EIF3FMTOR10875716541103 Affinity Capture-Western; Two-hybrid
EIF3FMTOR11421416541103 Affinity Capture-Western; Two-hybrid
LRPAP1MTOR10875716798736 Affinity Capture-Western
LRPAP1MTOR11022116798736 Affinity Capture-Western
PLD2MTOR11135416837165 Affinity Capture-Western
PLD2MTOR10875716837165 Affinity Capture-Western
MTORMTOR10875716870609 17360675 Affinity Capture-Western
MAPKAP1MTOR10875716962653 17043309 Affinity Capture-MS; Affinity Capture-Western
MAPKAP1MTOR12255116962653 17043309 Affinity Capture-MS; Affinity Capture-Western
FBXW7MTOR10875718787170 Affinity Capture-Western
FBXW7MTOR12058118787170 Affinity Capture-Western
TTI1MTOR10875720427287 Affinity Capture-Western
TTI1MTOR11503020427287 Affinity Capture-Western
TELO2MTOR10875720801936 Affinity Capture-Western
TELO2MTOR11522320801936 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1928394
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030131-2974'