AutismKB 2.0

Annotation Details for ABL1


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Basic Information Top
Gene Symbol:ABL1 ( ABL,JTK7,bcr/abl,c-ABL,p150,v-abl )
Gene Full Name: c-abl oncogene 1, non-receptor tyrosine kinase
Band: 9q34.12
Quick LinksEntrez ID:25; OMIM: 189980; Uniprot ID:ABL1_HUMAN; ENSEMBL ID: ENSG00000097007; HGNC ID: 76
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus9168116
GO:0005634NAS-nucleus8242749
GO:0005634TAS-nucleus20841568
GO:0005654IDA-nucleoplasm-
GO:0005654TAS-nucleoplasm-
GO:0005730IDA-nucleolus12944467
GO:0005737IDA-cytoplasm17515907
GO:0005737TAS-cytoplasm20841568
GO:0005739NAS-mitochondrion24522549
GO:0005829IDA-cytosol11120811
GO:0005829TAS-cytosol-
GO:0015629TAS-actin cytoskeleton20841568
GO:0016604IDA-nuclear body-
GO:0030425IDA-dendrite24658113
GO:0031234IBA-extrinsic component of cytoplasmic side of plasma membrane-
GO:0031252IEA-cell leading edge-
GO:0031965IEA-nuclear membrane-
GO:0043025IDA-neuronal cell body24658113
GO:0043234IPI-protein complex12384576
GO:0048471IDA-perinuclear region of cytoplasm17888034
GO:0098794TAS-postsynapse24658113
GO ID Evidence Qualifier GO_term References
GO:0000287IDA-magnesium ion binding9144171
GO:0001784IPI-phosphotyrosine residue binding20624904
GO:0003677NAS-DNA binding8242749
GO:0003785TAS-actin monomer binding20841568
GO:0004515TAS-nicotinate-nucleotide adenylyltransferase activity20841568
GO:0004672IDA-protein kinase activity11120811
GO:0004713EXP-protein tyrosine kinase activity15657136
GO:0004713IDA-protein tyrosine kinase activity7590236
GO:0004713IMP-protein tyrosine kinase activity24520051
GO:0004713TAS-protein tyrosine kinase activity-
GO:0004715IDA-non-membrane spanning protein tyrosine kinase activity9461559
GO:0005080IPI-protein kinase C binding10713049
GO:0005102IBA-receptor binding-
GO:0005515IPI-protein binding7590236
GO:0005524IDA-ATP binding9144171
GO:0008022IPI-protein C-terminus binding11971963
GO:0017124IPI-SH3 domain binding7590236
GO:0019905IPI-syntaxin binding23006999
GO:0030145IDA-manganese ion binding9144171
GO:0042169IPI-SH2 domain binding12384576
GO:0046875IEA-ephrin receptor binding-
GO:0051015IEA-actin filament binding-
GO:0051019IPI-mitogen-activated protein kinase binding11121037
GO:0070064IDA-proline-rich region binding15657060
GO:0070064IPI-proline-rich region binding7590236
GO ID Evidence Qualifier GO_term References
GO:0000278TAS-mitotic cell cycle24522549
GO:0001843IEA-neural tube closure-
GO:0001922IEA-B-1 B cell homeostasis-
GO:0001934IMP-positive regulation of protein phosphorylation24700464
GO:0002322IEA-B cell proliferation involved in immune response-
GO:0002333IEA-transitional one stage B cell differentiation-
GO:0006298TAS-mismatch repair10391249
GO:0006355TAS-regulation of transcription, DNA-templated8242749
GO:0006464NAS-cellular protein modification process8242749
GO:0006914IEA-autophagy-
GO:0006974IDA-cellular response to DNA damage stimulus15657060
GO:0006975IDA-DNA damage induced protein phosphorylation18280240
GO:0006979IGI-response to oxidative stress17626041
GO:0007050TAS-cell cycle arrest24522549
GO:0007173IEA-epidermal growth factor receptor signaling pathway-
GO:0007204IMP-positive regulation of cytosolic calcium ion concentration24367707
GO:0008630TAS-intrinsic apoptotic signaling pathway in response to DNA damage20841568
GO:0009791IEA-post-embryonic development-
GO:0010506TAS-regulation of autophagy20841568
GO:0018108IDA-peptidyl-tyrosine phosphorylation7590236
GO:0018108IMP-peptidyl-tyrosine phosphorylation24520051
GO:0018108TAS-peptidyl-tyrosine phosphorylation23626584
GO:0021587IEA-cerebellum morphogenesis-
GO:0022408IEA-negative regulation of cell-cell adhesion-
GO:0030035IEA-microspike assembly-
GO:0030036ISS-actin cytoskeleton organization-
GO:0030100TAS-regulation of endocytosis20841568
GO:0030155TAS-regulation of cell adhesion20841568
GO:0030514IEA-negative regulation of BMP signaling pathway-
GO:0030516IMP-regulation of axon extension24520051
GO:0031113IMP-regulation of microtubule polymerization24520051
GO:0032956IMP-regulation of actin cytoskeleton organization24520051
GO:0033690IEA-positive regulation of osteoblast proliferation-
GO:0034446IEA-substrate adhesion-dependent cell spreading-
GO:0034599TAS-cellular response to oxidative stress24522549
GO:0035791IMP-platelet-derived growth factor receptor-beta signaling pathway24520051
GO:0038083IDA-peptidyl-tyrosine autophosphorylation10518561
GO:0038083IMP-peptidyl-tyrosine autophosphorylation24520051
GO:0038096TAS-Fc-gamma receptor signaling pathway involved in phagocytosis-
GO:0042127IBA-regulation of cell proliferation-
GO:0042770IDA-signal transduction in response to DNA damage9037071
GO:0043065IDA-positive regulation of apoptotic process9037071
GO:0043123IEA-positive regulation of I-kappaB kinase/NF-kappaB signaling-
GO:0043124IEA-negative regulation of I-kappaB kinase/NF-kappaB signaling-
GO:0045087IBA-innate immune response-
GO:0045184IMP-establishment of protein localization24520051
GO:0045930IEA-negative regulation of mitotic cell cycle-
GO:0045931IEA-positive regulation of mitotic cell cycle-
GO:0046632IEA-alpha-beta T cell differentiation-
GO:0046777IDA-protein autophosphorylation10713049
GO:0048536IEA-spleen development-
GO:0048538IEA-thymus development-
GO:0048668IEA-collateral sprouting-
GO:0050731IDA-positive regulation of peptidyl-tyrosine phosphorylation15657060
GO:0050798IEA-activated T cell proliferation-
GO:0050853IEA-B cell receptor signaling pathway-
GO:0050885IEA-neuromuscular process controlling balance-
GO:0051149TAS-positive regulation of muscle cell differentiation-
GO:0051281IEA-positive regulation of release of sequestered calcium ion into cytosol-
GO:0051353IDA-positive regulation of oxidoreductase activity12893824
GO:0051444IDA-negative regulation of ubiquitin-protein transferase activity20823226
GO:0051444TAS-negative regulation of ubiquitin-protein transferase activity23626584
GO:0051882TAS-mitochondrial depolarization24522549
GO:0060020IEA-Bergmann glial cell differentiation-
GO:0060563IEA-neuroepithelial cell differentiation-
GO:0070301IDA-cellular response to hydrogen peroxide10713049
GO:0070373IEA-negative regulation of ERK1 and ERK2 cascade-
GO:0070374IEA-positive regulation of ERK1 and ERK2 cascade-
GO:0071222IEA-cellular response to lipopolysaccharide-
GO:0071901IDA-negative regulation of protein serine/threonine kinase activity11121037
GO:0072358IEA-cardiovascular system development-
GO:0090135IEA-actin filament branching-
GO:1900042IEA-positive regulation of interleukin-2 secretion-
GO:1900275IMP-negative regulation of phospholipase C activity24367707
GO:1901216IEA-positive regulation of neuron death-
GO:1902715IEA-positive regulation of interferon-gamma secretion-
GO:1903053IEA-regulation of extracellular matrix organization-
GO:1903351TAS-cellular response to dopamine24522549
GO:1904528IMP-positive regulation of microtubule binding24520051
GO:1904531IMP-positive regulation of actin filament binding24520051
GO:1990051IDA-activation of protein kinase C activity10713049
GO:2000096IEA-positive regulation of Wnt signaling pathway, planar cell polarity pathway-
GO:2000145TAS-regulation of cell motility20841568
GO:2000249TAS-regulation of actin cytoskeleton reorganization20841568
GO:2000352IEA-negative regulation of endothelial cell apoptotic process-
GO:2000773IEA-negative regulation of cellular senescence-
GO:2001020IDA-regulation of response to DNA damage stimulus9461559
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
SH3BP1ABL11065431379745 Reconstituted Complex
SH3BP1ABL11171491379745 Reconstituted Complex
BCRABL11065431712671 8112292 12543778 Affinity Capture-Western; Reconstituted Complex
BCRABL11070831712671 8112292 12543778 Affinity Capture-Western; Reconstituted Complex
CREB1ABL11077757565761 Reconstituted Complex
CREB1ABL11065437565761 Reconstituted Complex
ABI2ABL11154547590236 12569093 Affinity Capture-Western; Reconstituted Complex
ABI2ABL11065437590236 12569093 Affinity Capture-Western; Reconstituted Complex
ZAP70ABL11133677760813 Affinity Capture-Western
ZAP70ABL11065437760813 Affinity Capture-Western
BCAR1ABL11149347780740 8810278 Affinity Capture-Western; Biochemical Activity
BCAR1ABL11065437780740 8810278 Affinity Capture-Western; Biochemical Activity
CRKLABL11065437926767 8978305 9820532 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
CRKLABL11077897926767 8978305 9820532 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
GRB2ABL11065437926767 9407116 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
GRB2ABL11091427926767 9407116 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NCK1ABL11107707926767 11494134 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NCK1ABL11065437926767 11494134 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SHC1ABL11123618112292 10194451 Affinity Capture-Western
SHC1ABL11065438112292 10194451 Affinity Capture-Western
SOS1ABL11125378112292 Affinity Capture-Western
SOS1ABL11065438112292 Affinity Capture-Western
RB1ABL11065438242749 9071815 Affinity Capture-Western; Reconstituted Complex
RB1ABL11118608242749 9071815 Affinity Capture-Western; Reconstituted Complex
PIK3R1ABL11065438294442 Reconstituted Complex
PIK3R1ABL11113138294442 Reconstituted Complex
NEDD9ABL11108168668148 8879209 Affinity Capture-Western
NEDD9ABL11065438668148 8879209 Affinity Capture-Western
PTPN6ABL11065438692915 Affinity Capture-Western
PTPN6ABL11117428692915 Affinity Capture-Western
RYBPABL11065438943360 Far Western; Reconstituted Complex; Two-hybrid
RYBPABL11169978943360 Far Western; Reconstituted Complex; Two-hybrid
GRB10ABL11065439006901 9747873 Affinity Capture-Western; Reconstituted Complex
GRB10ABL11091449006901 9747873 Affinity Capture-Western; Reconstituted Complex
DOK1ABL11065439008161 11071635 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
DOK1ABL11081319008161 11071635 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
ABI1ABL11065439010225 11418237 12672821 Affinity Capture-Western; Reconstituted Complex
ABI1ABL11153249010225 11418237 12672821 Affinity Capture-Western; Reconstituted Complex
ATMABL11065439168117 10212258 11375976 17409407 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
ATMABL11069629168117 10212258 11375976 17409407 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
SORBS2ABL11065439211900 12475393 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
SORBS2ABL11140479211900 12475393 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
PRKDCABL11065439312071 Reconstituted Complex
PRKDCABL11115779312071 Reconstituted Complex
SHDABL11212839315092 Biochemical Activity; Two-hybrid
SHDABL11065439315092 Biochemical Activity; Two-hybrid
SHEABL11260099315092 Two-hybrid
SHEABL11065439315092 Two-hybrid
PAG1ABL11065439334312 Affinity Capture-Western; Two-hybrid
PAG1ABL11209319334312 Affinity Capture-Western; Two-hybrid
HCKABL11065439407116 Affinity Capture-Western
HCKABL11093059407116 Affinity Capture-Western
RFX1ABL11119219583676 Affinity Capture-Western; Reconstituted Complex
RFX1ABL11065439583676 Affinity Capture-Western; Reconstituted Complex
SPTA1ABL11065439593709 Affinity Capture-Western; Reconstituted Complex
SPTA1ABL11125869593709 Affinity Capture-Western; Reconstituted Complex
SPTAN1ABL11065439593709 Reconstituted Complex; Two-hybrid
SPTAN1ABL11125879593709 Reconstituted Complex; Two-hybrid
ST5ABL11065439632734 Reconstituted Complex
ST5ABL11126429632734 Reconstituted Complex
JAK1ABL11065439774693 Reconstituted Complex
JAK1ABL11099199774693 Reconstituted Complex
XRCC6ABL11065439798959 Affinity Capture-Western
XRCC6ABL11088229798959 Affinity Capture-Western
SLC9A2ABL110654310187839 Reconstituted Complex
SLC9A2ABL111243910187839 Reconstituted Complex
INPPL1ABL110984810194451 Affinity Capture-Western
INPPL1ABL110654310194451 Affinity Capture-Western
RAD51ABL110654310212258 Affinity Capture-Western; Reconstituted Complex
RAD51ABL111182510212258 Affinity Capture-Western; Reconstituted Complex
TP73ABL111301410391250 10391251 Affinity Capture-Western; Reconstituted Complex
TP73ABL110654310391250 10391251 Affinity Capture-Western; Reconstituted Complex
TUBABL110654310455176 Biochemical Activity
TUBABL111312610455176 Biochemical Activity
ATRABL110702710608806 Protein-peptide
ATRABL110654310608806 Protein-peptide
TP53ABL111301010629029 Reconstituted Complex
TP53ABL110654310629029 Reconstituted Complex
NTRK1ABL111096910679771 10708759 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NTRK1ABL110654310679771 10708759 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PLCG1ABL110654310708759 Reconstituted Complex
PLCG1ABL111135110708759 Reconstituted Complex
MTORABL110654310753870 Affinity Capture-Western
MTORABL110875710753870 Affinity Capture-Western
EVLABL110654310945997 Reconstituted Complex
EVLABL111955610945997 Reconstituted Complex
PAK2ABL111109811121037 Affinity Capture-Western; Biochemical Activity
PAK2ABL110654311121037 Affinity Capture-Western; Biochemical Activity
PSTPIP1ABL110654311163214 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PSTPIP1ABL111451311163214 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SORBS1ABL110654311374898 Affinity Capture-Western
SORBS1ABL111583111374898 Affinity Capture-Western
TERF1ABL110654311375976 Affinity Capture-Western
TERF1ABL111287211375976 Affinity Capture-Western
RANABL110654311420673 Affinity Capture-Western
RANABL111183711420673 Affinity Capture-Western
ARHGAP17ABL112042411431473 Reconstituted Complex
ARHGAP17ABL110654311431473 Reconstituted Complex
EPHB2ABL110836211494128 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
EPHB2ABL110654311494128 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
EPHA3ABL110835611494128 Reconstituted Complex
EPHA3ABL110654311494128 Reconstituted Complex
SRCABL110654311494128 Reconstituted Complex
SRCABL111259211494128 Reconstituted Complex
CBLABL110654311494134 12475393 Affinity Capture-Western; Biochemical Activity; Far Western
CBLABL110731511494134 12475393 Affinity Capture-Western; Biochemical Activity; Far Western
VAV1ABL111325211790798 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
VAV1ABL110654311790798 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
MICAL1ABL112229011827972 Reconstituted Complex
MICAL1ABL110654311827972 Reconstituted Complex
CABLES2ABL110654311955625 Affinity Capture-Western
CABLES2ABL112362811955625 Affinity Capture-Western
RAD9AABL110654311971963 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
RAD9AABL111182011971963 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
ZDHHC16ABL112401412021275 Affinity Capture-Western; Two-hybrid
ZDHHC16ABL110654312021275 Affinity Capture-Western; Two-hybrid
BRCA1ABL110654312024016 Affinity Capture-Western
BRCA1ABL110714012024016 Affinity Capture-Western
MDM2ABL110654312110584 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
MDM2ABL111035812110584 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
NFKBIAABL110654312167702 Affinity Capture-Western; Reconstituted Complex
NFKBIAABL111085912167702 Affinity Capture-Western; Reconstituted Complex
ABL2ABL110654512569093 Affinity Capture-Western; Reconstituted Complex
ABL2ABL110654312569093 Affinity Capture-Western; Reconstituted Complex
ABL1ABL110654312654250 Protein-peptide
CATABL110654312777400 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
CATABL110729712777400 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
GPX1ABL110654312893824 Affinity Capture-Western; Reconstituted Complex
GPX1ABL110913412893824 Affinity Capture-Western; Reconstituted Complex
YTHDC1ABL110654315175272 Affinity Capture-Western; Biochemical Activity
YTHDC1ABL112487115175272 Affinity Capture-Western; Biochemical Activity
HSPA4ABL110954015937340 Affinity Capture-Western
HSPA4ABL110654315937340 Affinity Capture-Western
HSP90AA1ABL110955215937340 Affinity Capture-Western
HSP90AA1ABL110654315937340 Affinity Capture-Western
TOPBP1ABL111625615961388 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
TOPBP1ABL110654315961388 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
NCOA3ABL111384118765637 Affinity Capture-Western; Reconstituted Complex
NCOA3ABL110654318765637 Affinity Capture-Western; Reconstituted Complex
Gene Symbol Interactant Interaction ID References Description
ABI1ABL119470111418237 hNap1BP interacts with Abl.
NCF1CABL121663212681507 c-Abl interacts with p47phox.
RIN1ABL129560315886098 ABL1 interacts with and phosphorylates RIN1.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:87859
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-100812-9'