AutismKB 2.0

Annotation Details for FYN


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Basic Information Top
Gene Symbol:FYN ( MGC45350,SLK,SYN )
Gene Full Name: FYN oncogene related to SRC, FGR, YES
Band: 6q21
Quick LinksEntrez ID:2534; OMIM: 137025; Uniprot ID:FYN_HUMAN; ENSEMBL ID: ENSG00000010810; HGNC ID: 4037
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IEA-nucleus-
GO:0005739IEA-mitochondrion-
GO:0005768IDA-endosome15611048
GO:0005829IDA-cytosol-
GO:0005829TAS-cytosol-
GO:0005884IEA-actin filament-
GO:0005886IDA-plasma membrane12150984
GO:0014069ISS-postsynaptic density-
GO:0030425ISS-dendrite-
GO:0031234IBA-extrinsic component of cytoplasmic side of plasma membrane-
GO:0045121IDAcolocalizes_withmembrane raft12150984
GO:0045121IMP-membrane raft23386614
GO ID Evidence Qualifier GO_term References
GO:0001664IEA-G-protein coupled receptor binding-
GO:0001948IPI-glycoprotein binding16831868
GO:0004713EXP-protein tyrosine kinase activity1381360
GO:0004713IMP-protein tyrosine kinase activity16979591
GO:0004713TAS-protein tyrosine kinase activity-
GO:0004715IBA-non-membrane spanning protein tyrosine kinase activity-
GO:0004715NAS-non-membrane spanning protein tyrosine kinase activity7822789
GO:0004871IEA-signal transducer activity-
GO:0005088TAS-Ras guanyl-nucleotide exchange factor activity-
GO:0005515IPI-protein binding1661130
GO:0005524IEA-ATP binding-
GO:0015631IEA-tubulin binding-
GO:0019899IEA-enzyme binding-
GO:0042608IEA-T cell receptor binding-
GO:0042609IEA-CD4 receptor binding-
GO:0042610IEA-CD8 receptor binding-
GO:0042802IPI-identical protein binding14993658
GO:0043548IEA-phosphatidylinositol 3-kinase binding-
GO:0044325IEA-ion channel binding-
GO:0046872IEA-metal ion binding-
GO:0046875IPI-ephrin receptor binding10498895
GO:0046934TAS-phosphatidylinositol-4,5-bisphosphate 3-kinase activity-
GO:0051428IEA-peptide hormone receptor binding-
GO:0070851IPI-growth factor receptor binding16479011
GO:0097718IPI-disordered domain specific binding9351809
GO ID Evidence Qualifier GO_term References
GO:0000165TAS-MAPK cascade-
GO:0001764IEA-neuron migration-
GO:0002223TAS-stimulatory C-type lectin receptor signaling pathway-
GO:0002250IEA-adaptive immune response-
GO:0006468NAS-protein phosphorylation7822789
GO:0006816NAS-calcium ion transport7822789
GO:0007169IBA-transmembrane receptor protein tyrosine kinase signaling pathway-
GO:0007411TAS-axon guidance-
GO:0007417IBA-central nervous system development-
GO:0007596TAS-blood coagulation-
GO:0007612TAS-learning1361685
GO:0007631TAS-feeding behavior8264796
GO:0008360IEA-regulation of cell shape-
GO:0010629IEA-negative regulation of gene expression-
GO:0010976IEA-positive regulation of neuron projection development-
GO:0014066TAS-regulation of phosphatidylinositol 3-kinase signaling-
GO:0014068IEA-positive regulation of phosphatidylinositol 3-kinase signaling-
GO:0016032IEA-viral process-
GO:0016477IBA-cell migration-
GO:0018108IMP-peptidyl-tyrosine phosphorylation16979591
GO:0030154IBA-cell differentiation-
GO:0030168TAS-platelet activation-
GO:0030900IEA-forebrain development-
GO:0031295TAS-T cell costimulation-
GO:0031397IEA-negative regulation of protein ubiquitination-
GO:0035556TAS-intracellular signal transduction1361685
GO:0036120IEA-cellular response to platelet-derived growth factor stimulus-
GO:0038083IBA-peptidyl-tyrosine autophosphorylation-
GO:0038096TAS-Fc-gamma receptor signaling pathway involved in phagocytosis-
GO:0042110IBA-T cell activation-
GO:0042127IBA-regulation of cell proliferation-
GO:0042177IEA-negative regulation of protein catabolic process-
GO:0042493IEA-response to drug-
GO:0042531IEA-positive regulation of tyrosine phosphorylation of STAT protein-
GO:0042981IBA-regulation of apoptotic process-
GO:0043123IEA-positive regulation of I-kappaB kinase/NF-kappaB signaling-
GO:0043524IEA-negative regulation of neuron apoptotic process-
GO:0043547IEA-positive regulation of GTPase activity-
GO:0045087IBA-innate immune response-
GO:0045471IEA-response to ethanol-
GO:0046854IEA-phosphatidylinositol phosphorylation-
GO:0048010TAS-vascular endothelial growth factor receptor signaling pathway-
GO:0048013TAS-ephrin receptor signaling pathway-
GO:0048015TAS-phosphatidylinositol-mediated signaling-
GO:0048813IEA-dendrite morphogenesis-
GO:0050690TAS-regulation of defense response to virus by virus-
GO:0050798IEA-activated T cell proliferation-
GO:0050852IDA-T cell receptor signaling pathway7722293
GO:0050900TAS-leukocyte migration-
GO:0050966IEA-detection of mechanical stimulus involved in sensory perception of pain-
GO:0071375IEA-cellular response to peptide hormone stimulus-
GO:0071560IEA-cellular response to transforming growth factor beta stimulus-
GO:0090314IEA-positive regulation of protein targeting to membrane-
GO:1900182IEA-positive regulation of protein localization to nucleus-
GO:1901216IEA-positive regulation of neuron death-
GO:1902951IEA-negative regulation of dendritic spine maintenance-
GO:1904645IEA-response to amyloid-beta-
GO:1905664IEA-regulation of calcium ion import across plasma membrane-
GO:2001240IEA-negative regulation of extrinsic apoptotic signaling pathway in absence of ligand-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
FYNADD210663211526103 Affinity Capture-Western; Reconstituted Complex
FYNADD210881011526103 Affinity Capture-Western; Reconstituted Complex
FYNFAS1068518626376 Affinity Capture-Western
FYNFAS1088108626376 Affinity Capture-Western
FYNFASLG1068527589480 11741599 17164290 Reconstituted Complex
FYNFASLG1088107589480 11741599 17164290 Reconstituted Complex
FYNBCL31088109576921 Reconstituted Complex
FYNBCL31070749576921 Reconstituted Complex
FYNBTK1071608058772 Reconstituted Complex
FYNBTK1088108058772 Reconstituted Complex
FYNCBL1073159535867 12244174 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
FYNCBL1088109535867 12244174 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
FYNCD21073529677430 Reconstituted Complex
FYNCD21088109677430 Reconstituted Complex
FYNMS4A11073697545683 Affinity Capture-Western
FYNMS4A11088107545683 Affinity Capture-Western
FYNCD361088101715582 7521304 Affinity Capture-Western
FYNCD361073861715582 7521304 Affinity Capture-Western
FYNCD441073989573028 Affinity Capture-Western; Co-fractionation
FYNCD441088109573028 Affinity Capture-Western; Co-fractionation
FYNCDK11074208910336 Affinity Capture-Western
FYNCDK11088108910336 Affinity Capture-Western
FYNCDH110743412640114 Affinity Capture-Western; Reconstituted Complex
FYNCDH110881012640114 Affinity Capture-Western; Reconstituted Complex
FYNCHRNA710756111278378 Affinity Capture-Western
FYNCHRNA710881011278378 Affinity Capture-Western
FYNCSF1R1078237681396 Affinity Capture-Western; Reconstituted Complex
FYNCSF1R1088107681396 Affinity Capture-Western; Reconstituted Complex
FYNCSK1078328262983 Affinity Capture-Western
FYNCSK1088108262983 Affinity Capture-Western
FYNCTLA41078759712716 Affinity Capture-Western
FYNCTLA41088109712716 Affinity Capture-Western
FYNCTNNB110788012640114 Biochemical Activity
FYNCTNNB110881012640114 Biochemical Activity
FYNCTNND110788112640114 12835311 Affinity Capture-Western; Biochemical Activity
FYNCTNND110881012640114 12835311 Affinity Capture-Western; Biochemical Activity
FYNDAG110797511724572 Affinity Capture-Western; Reconstituted Complex
FYNDAG110881011724572 Affinity Capture-Western; Reconstituted Complex
FYNDLG41080869892651 12419528 Affinity Capture-Western
FYNDLG41088109892651 12419528 Affinity Capture-Western
FYNEPHA31083569632142 Reconstituted Complex
FYNEPHA31088109632142 Reconstituted Complex
FYNEPHA410835712084815 Affinity Capture-Western
FYNEPHA410881012084815 Affinity Capture-Western
FYNEPHA810836010498895 Affinity Capture-Western; Reconstituted Complex
FYNEPHA810881010498895 Affinity Capture-Western; Reconstituted Complex
FYNEPHB31083639674711 Reconstituted Complex
FYNEPHB31088109674711 Reconstituted Complex
FYNPTK2B1084809091579 9104812 10867021 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
FYNPTK2B1088109091579 9104812 10867021 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
FYNFYB1088097504057 9748251 Affinity Capture-Western; Reconstituted Complex
FYNFYB1088107504057 9748251 Affinity Capture-Western; Reconstituted Complex
PIK3R2FYN1088101334406 Biochemical Activity; Reconstituted Complex
PIK3R2FYN1113141334406 Biochemical Activity; Reconstituted Complex
THY1FYN1088101351058 Affinity Capture-Western
THY1FYN1129261351058 Affinity Capture-Western
IL7RFYN1088107515933 Affinity Capture-Western
IL7RFYN1097897515933 Affinity Capture-Western
RAF1FYN1088107517401 Affinity Capture-Western; Reconstituted Complex
RAF1FYN1118317517401 Affinity Capture-Western; Reconstituted Complex
MAGFYN1088107525550 Reconstituted Complex
MAGFYN1102737525550 Reconstituted Complex
WASFYN1132937565724 8805332 10532312 Affinity Capture-Western; Reconstituted Complex
WASFYN1088107565724 8805332 10532312 Affinity Capture-Western; Reconstituted Complex
FYNFYN1088107687536 Co-crystal Structure
ZAP70FYN1133677760813 Affinity Capture-Western; Phenotypic Enhancement
ZAP70FYN1088107760813 Affinity Capture-Western; Phenotypic Enhancement
PIK3R1FYN1088108294442 Reconstituted Complex
PIK3R1FYN1113138294442 Reconstituted Complex
PLCG2FYN1088108395016 Reconstituted Complex
PLCG2FYN1113528395016 Reconstituted Complex
ITKFYN1088108810341 10636929 Reconstituted Complex
ITKFYN1099078810341 10636929 Reconstituted Complex
KHDRBS1FYN1159009045636 11960376 Affinity Capture-Western; Reconstituted Complex
KHDRBS1FYN1088109045636 11960376 Affinity Capture-Western; Reconstituted Complex
SRCFYN1088109169421 Protein-peptide
SRCFYN1125929169421 Protein-peptide
BCAR1FYN1149349188452 10739664 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BCAR1FYN1088109188452 10739664 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SKAP1FYN1141849195899 9748251 12171928 Affinity Capture-Western; Reconstituted Complex
SKAP1FYN1088109195899 9748251 12171928 Affinity Capture-Western; Reconstituted Complex
TYK2FYN1131489196040 Affinity Capture-Western; Reconstituted Complex
TYK2FYN1088109196040 Affinity Capture-Western; Reconstituted Complex
NEDD9FYN1088109360983 Affinity Capture-Western
NEDD9FYN1108169360983 Affinity Capture-Western
PTPRAFYN1088109535845 Affinity Capture-Western
PTPRAFYN1117509535845 Affinity Capture-Western
SYKFYN1088109535867 Affinity Capture-Western; Reconstituted Complex
SYKFYN1127179535867 Affinity Capture-Western; Reconstituted Complex
SDC3FYN1150279553134 Reconstituted Complex
SDC3FYN1088109553134 Reconstituted Complex
NTRK2FYN1088109648856 Affinity Capture-Western; Reconstituted Complex
NTRK2FYN1109709648856 Affinity Capture-Western; Reconstituted Complex
MCAMFYN1088109756930 Affinity Capture-Western
MCAMFYN1103329756930 Affinity Capture-Western
VAV1FYN1132529822663 Affinity Capture-Western
VAV1FYN1088109822663 Affinity Capture-Western
SKAP2FYN1088109837776 Affinity Capture-Western
SKAP2FYN1144489837776 Affinity Capture-Western
SH3BP2FYN1088109846481 Two-hybrid
SH3BP2FYN1123509846481 Two-hybrid
SOS1FYN1088109856337 Reconstituted Complex
SOS1FYN1125379856337 Reconstituted Complex
GRIN2AFYN1088109892651 10458595 12419528 12932824 Affinity Capture-Western; Reconstituted Complex
GRIN2AFYN1091609892651 10458595 12419528 12932824 Affinity Capture-Western; Reconstituted Complex
SOCS1FYN11420310022833 Reconstituted Complex
SOCS1FYN10881010022833 Reconstituted Complex
SIT1FYN11808810209036 Affinity Capture-Western
SIT1FYN10881010209036 Affinity Capture-Western
PTPN11FYN10881010212213 Affinity Capture-Western
PTPN11FYN11174510212213 Affinity Capture-Western
PRKCQFYN10881010383400 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
PRKCQFYN11157410383400 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
GRIN2BFYN10881010458595 Reconstituted Complex
GRIN2BFYN10916110458595 Reconstituted Complex
JAK2FYN10881010551884 Affinity Capture-Western; Reconstituted Complex
JAK2FYN10992010551884 Affinity Capture-Western; Reconstituted Complex
CBLCFYN11715610571044 Affinity Capture-Western; Reconstituted Complex
CBLCFYN10881010571044 Affinity Capture-Western; Reconstituted Complex
CD226FYN11590810591186 Affinity Capture-Western
CD226FYN10881010591186 Affinity Capture-Western
FNBP4FYN11694110744724 Reconstituted Complex
FNBP4FYN10881010744724 Reconstituted Complex
PAG1FYN12093110790433 Affinity Capture-Western; Reconstituted Complex
PAG1FYN10881010790433 Affinity Capture-Western; Reconstituted Complex
TRAT1FYN11915410790433 Reconstituted Complex
TRAT1FYN10881010790433 Reconstituted Complex
PXNFYN10881010804218 Affinity Capture-Western
PXNFYN11178710804218 Affinity Capture-Western
PECAM1FYN10881010858437 Affinity Capture-Western
PECAM1FYN11120110858437 Affinity Capture-Western
GRB10FYN10914410871840 Biochemical Activity
GRB10FYN10881010871840 Biochemical Activity
TNK2FYN11548511087735 Affinity Capture-Western; Reconstituted Complex
TNK2FYN10881011087735 Affinity Capture-Western; Reconstituted Complex
SNCAFYN10881011162638 Biochemical Activity
SNCAFYN11250611162638 Biochemical Activity
PTK2FYN10881011278857 12558988 Affinity Capture-Western; Co-crystal Structure
PTK2FYN11171911278857 12558988 Affinity Capture-Western; Co-crystal Structure
MAP2FYN10881011546790 Affinity Capture-Western
MAP2FYN11030511546790 Affinity Capture-Western
NMT1FYN10881011594778 Biochemical Activity
NMT1FYN11089911594778 Biochemical Activity
TOM1L1FYN11535211711534 Reconstituted Complex
TOM1L1FYN10881011711534 Reconstituted Complex
GAB3FYN12658111739737 Reconstituted Complex
GAB3FYN10881011739737 Reconstituted Complex
ADAM15FYN10881011741929 Reconstituted Complex
ADAM15FYN11428711741929 Reconstituted Complex
MAPTFYN10881011826099 Affinity Capture-Western; Reconstituted Complex
MAPTFYN11030811826099 Affinity Capture-Western; Reconstituted Complex
TUBA3CFYN10881011826099 Affinity Capture-Western; Reconstituted Complex
TUBA3CFYN11312911826099 Affinity Capture-Western; Reconstituted Complex
GP6FYN11937911943772 Reconstituted Complex
GP6FYN10881011943772 Reconstituted Complex
GNB2L1FYN11567111943848 12524444 Affinity Capture-Western; Reconstituted Complex
GNB2L1FYN10881011943848 12524444 Affinity Capture-Western; Reconstituted Complex
PTPN5FYN10881011983687 Affinity Capture-Western
PTPN5FYN12431211983687 Affinity Capture-Western
RPL10FYN10881012138090 Reconstituted Complex
RPL10FYN11205412138090 Reconstituted Complex
WASLFYN11446612431372 Biochemical Activity
WASLFYN10881012431372 Biochemical Activity
SH2D1AFYN10881012458214 12545174 Affinity Capture-Western; Reconstituted Complex
SH2D1AFYN11024612458214 12545174 Affinity Capture-Western; Reconstituted Complex
TRPV4FYN12188312538589 Affinity Capture-Western
TRPV4FYN10881012538589 Affinity Capture-Western
SLAMF1FYN10881012545174 Reconstituted Complex
SLAMF1FYN11239512545174 Reconstituted Complex
YES1FYN11335712640114 Affinity Capture-Western
YES1FYN10881012640114 Affinity Capture-Western
NPHS1FYN10881012668668 12846735 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
NPHS1FYN11092812668668 12846735 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
TNFRSF1AFYN10881012753742 Co-fractionation
TNFRSF1AFYN11298612753742 Co-fractionation
ARHGAP32FYN11509112788081 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
ARHGAP32FYN10881012788081 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
UNC119FYN11454814757743 Affinity Capture-Western; Reconstituted Complex
UNC119FYN10881014757743 Affinity Capture-Western; Reconstituted Complex
TRPC6FYN10881014761972 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
TRPC6FYN11307614761972 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
YTHDC1FYN12487115175272 Biochemical Activity
YTHDC1FYN10881015175272 Biochemical Activity
ITCHFYN10881016387660 Affinity Capture-Western; Reconstituted Complex
ITCHFYN12374716387660 Affinity Capture-Western; Reconstituted Complex
Gene Symbol Interactant Interaction ID References Description
DOK4FYN18553312730241 IRS5/DOK4 interacts with Fyn. This interaction was modelled on a demonstrated interaction between human IRS5/DOK4 and hamster Fyn.
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
FYNrs3730353, rs6916861, rs706872, rs706895 Gene overview in AlzGene
Gene Symbol Poly Names Gene overview in PDGene
FYNrs6910116 Gene overview in PDGene
Gene Symbol Poly Names Gene overview in SZGene
FYND6S302, FYN_93A/G, FYN_Ex12+894T/G, FYN_IVS10+37T/C Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:95602
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030903-5'