AutismKB 2.0

Annotation Details for GAB1


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Basic Information Top
Gene Symbol:GAB1 ( - )
Gene Full Name: GRB2-associated binding protein 1
Band: 4q31.21
Quick LinksEntrez ID:2549; OMIM: 604439; Uniprot ID:GAB1_HUMAN; ENSEMBL ID: ENSG00000109458; HGNC ID: 4066
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005829TAS-cytosol-
GO ID Evidence Qualifier GO_term References
GO:0005070TAS-SH3/SH2 adaptor activity8596638
GO:0005515IPI-protein binding9658397
GO:0016303TAS-1-phosphatidylinositol-3-kinase activity-
GO:0046934TAS-phosphatidylinositol-4,5-bisphosphate 3-kinase activity-
GO ID Evidence Qualifier GO_term References
GO:0007173TAS-epidermal growth factor receptor signaling pathway-
GO:0007411TAS-axon guidance-
GO:0008283TAS-cell proliferation8596638
GO:0008286TAS-insulin receptor signaling pathway8596638
GO:0009967IEA-positive regulation of signal transduction-
GO:0014066TAS-regulation of phosphatidylinositol 3-kinase signaling-
GO:0035728IEA-response to hepatocyte growth factor-
GO:0036092IEA-phosphatidylinositol-3-phosphate biosynthetic process-
GO:0038128TAS-ERBB2 signaling pathway-
GO:0046854IEA-phosphatidylinositol phosphorylation-
GO:0048015TAS-phosphatidylinositol-mediated signaling-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
GAB1C1QBP10882410747014 Affinity Capture-Western
GAB1C1QBP10716910747014 Affinity Capture-Western
GAB1CRKL10882410753869 Affinity Capture-Western
GAB1CRKL10778910753869 Affinity Capture-Western
GAB1EGFR10882411432805 Affinity Capture-Western
GAB1EGFR10827611432805 Affinity Capture-Western
PLCG1GAB11088248596638 11507676 Affinity Capture-Western; Far Western
PLCG1GAB11113518596638 11507676 Affinity Capture-Western; Far Western
GRB2GAB11088248596638 11314042 11960376 20936779 Affinity Capture-Western; Far Western; Reconstituted Complex; Two-hybrid
GRB2GAB11091428596638 11314042 11960376 20936779 Affinity Capture-Western; Far Western; Reconstituted Complex; Two-hybrid
PIK3R1GAB11088248596638 9658397 9891995 Affinity Capture-Western; Far Western; Reconstituted Complex; Two-hybrid
PIK3R1GAB11113138596638 9658397 9891995 Affinity Capture-Western; Far Western; Reconstituted Complex; Two-hybrid
PTPN11GAB11088249658397 11940581 Affinity Capture-Western; Two-hybrid
PTPN11GAB11117459658397 11940581 Affinity Capture-Western; Two-hybrid
GRAP2GAB11147999878555 Two-hybrid
GRAP2GAB11088249878555 Two-hybrid
METGAB111039110871282 Affinity Capture-Western
METGAB110882410871282 Affinity Capture-Western
MAP3K3GAB111037912065326 Affinity Capture-Western; Reconstituted Complex
MAP3K3GAB110882412065326 Affinity Capture-Western; Reconstituted Complex
ROCK1GAB110882412748184 Co-crystal Structure
ROCK1GAB111202012748184 Co-crystal Structure
ARHGAP32GAB111509112819203 Affinity Capture-Western
ARHGAP32GAB110882412819203 Affinity Capture-Western
Gene Symbol Interactant Interaction ID References Description
METGAB119476811894096 Met interacts with Gab1.
ARHGAP32GAB118253812819203 Gab1 interacts with GC-GAP.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:108088
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040426-2674'