AutismKB 2.0

Annotation Details for GAD1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:GAD1 ( FLJ45882,GAD,SCP )
Gene Full Name: glutamate decarboxylase 1 (brain, 67kDa)
Band: 2q31.1
Quick LinksEntrez ID:2571; OMIM: 605363; Uniprot ID:DCE1_HUMAN; ENSEMBL ID: ENSG00000128683; HGNC ID: 4092
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005622IDA-intracellular10671565
GO:0005739IEA-mitochondrion-
GO:0005886TAS-plasma membrane-
GO:0005938IEA-cell cortex-
GO:0012506NAS-vesicle membrane10671565
GO:0030424IEA-axon-
GO:0043679IEA-axon terminus-
GO:0048786IEA-presynaptic active zone-
GO:0060077IEA-inhibitory synapse-
GO:0061202TAS-clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane-
GO ID Evidence Qualifier GO_term References
GO:0004351IDA-glutamate decarboxylase activity10671565
GO:0004351TAS-glutamate decarboxylase activity-
GO:0005515IPI-protein binding10671565
GO:0016595IEA-glutamate binding-
GO:0030170IEA-pyridoxal phosphate binding-
GO:0046982IEA-protein heterodimerization activity-
GO:0047485IEA-protein N-terminus binding-
GO ID Evidence Qualifier GO_term References
GO:0006538TAS-glutamate catabolic process10671565
GO:0006540TAS-glutamate decarboxylation to succinate1549570
GO:0007268TAS-chemical synaptic transmission8954991
GO:0007269TAS-neurotransmitter secretion-
GO:0009449IEA-gamma-aminobutyric acid biosynthetic process-
GO:0018352TAS-protein-pyridoxal-5-phosphate linkage10671565
GO:0035176IEA-social behavior-
GO:0035641IEA-locomotory exploration behavior-
GO:0042136IEA-neurotransmitter biosynthetic process-
GO:0042493IEA-response to drug-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
GAD2GAD11088457836456 Affinity Capture-Western
GAD2GAD11088467836456 Affinity Capture-Western
PRKACAGAD111155315147202 Biochemical Activity
PRKACAGAD110884515147202 Biochemical Activity
PRKCEGAD111156715147202 Biochemical Activity
PRKCEGAD110884515147202 Biochemical Activity
HAAOGAD110884516189514 Two-hybrid
HAAOGAD111704716189514 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
GAD1GAD1_27379C/T, GAD1_292A/C, GAD1_41702A/G, GAD1_496C/T, GAD1_661C/T, rs10191129, rs10432420, rs12185692, rs16823181, rs16858996, rs17701824, rs1978340, rs2241164, rs2241165, rs2270335, rs2356236, rs3749034, rs3749035, rs3762553, rs3762554, rs3762555, rs3762556, rs3762561, rs3791850, rs3791851, rs3791857, rs3791858, rs3791878, rs3828275, rs4668331, rs6755102, rs701492, rs7557793, rs769390, rs769395, rs769404, rs769407, rs869395, rs872123 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:95632
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030909-3'