AutismKB 2.0

Annotation Details for NGEF


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Basic Information Top
Gene Symbol:NGEF ( ARHGEF27,EPHEXIN )
Gene Full Name: neuronal guanine nucleotide exchange factor
Band: 2q37.1
Quick LinksEntrez ID:25791; OMIM: 605991; Uniprot ID:NGEF_HUMAN; ENSEMBL ID: ENSG00000066248; HGNC ID: 7807
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005829TAS-cytosol-
GO:0016020IEA-membrane-
GO:0030426IEA-growth cone-
GO ID Evidence Qualifier GO_term References
GO:0005085EXP-guanyl-nucleotide exchange factor activity15848799
GO:0005085TAS-guanyl-nucleotide exchange factor activity-
GO:0005089TAS-Rho guanyl-nucleotide exchange factor activity-
GO ID Evidence Qualifier GO_term References
GO:0035023IEA-regulation of Rho protein signal transduction-
GO:0043065TAS-positive regulation of apoptotic process-
GO:0043087ISS-regulation of GTPase activity-
GO:0043547IEA-positive regulation of GTPase activity-
GO:0048013ISS-ephrin receptor signaling pathway-
GO:0048013TAS-ephrin receptor signaling pathway-
GO:0051056TAS-regulation of small GTPase mediated signal transduction-
GO:0061002ISS-negative regulation of dendritic spine morphogenesis-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
NGEFATP5C110699716169070 Two-hybrid
NGEFATP5C111732416169070 Two-hybrid
NGEFEPHA411732411336673 Affinity Capture-Western
NGEFEPHA410835711336673 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1858414
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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