AutismKB 2.0

Annotation Details for GCA


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Basic Information Top
Gene Symbol:GCA ( GCL )
Gene Full Name: grancalcin, EF-hand calcium binding protein
Band: 2q24.2
Quick LinksEntrez ID:25801; OMIM: 607030; Uniprot ID:GRAN_HUMAN; ENSEMBL ID: ENSG00000115271; HGNC ID: 15990
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576TAS-extracellular region-
GO:0005737IBA-cytoplasm-
GO:0005829IDA-cytosol-
GO:0005886IDA-plasma membrane-
GO:0035578TAS-azurophil granule lumen-
GO:0070062IDA-extracellular exosome19056867
GO ID Evidence Qualifier GO_term References
GO:0004198IBA-calcium-dependent cysteine-type endopeptidase activity-
GO:0005509IDA-calcium ion binding11717497
GO:0005515IPI-protein binding25416956
GO:0042803IPI-protein homodimerization activity11717497
GO:0046982IPI-protein heterodimerization activity12804766
GO ID Evidence Qualifier GO_term References
GO:0006508IBA-proteolysis-
GO:0043312TAS-neutrophil degranulation-
GO:0061025TAS-membrane fusion1530588
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
GCALCP111733311279160 Affinity Capture-Western
GCALCP111012811279160 Affinity Capture-Western
GCASRI11259512804766 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
GCASRI11733312804766 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
GCAGCA11733310903868 Reconstituted Complex
Gene Symbol Interactant Interaction ID References Description
GCASRI18315212804766 Sorcin interacts with grancalcin to form a heterodimer.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1918521
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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