AutismKB 2.0

Annotation Details for ARIH1


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Basic Information Top
Gene Symbol:ARIH1 ( ARI,DKFZp686O13120,FLJ20329,FLJ93118,HARI,HHARI,UBCH7BP )
Gene Full Name: ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 (Drosophila)
Band: 15q24.1
Quick LinksEntrez ID:25820; OMIM: 605624; Uniprot ID:ARI1_HUMAN; ENSEMBL ID: ENSG00000166233; HGNC ID: 689
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000151TAS-ubiquitin ligase complex10521492
GO:0005737IDA-cytoplasm11278816
GO:0005829TAS-cytosol-
GO:0015030IEA-Cajal body-
GO:0016604IDA-nuclear body23059369
GO:0019005IDAcolocalizes_withSCF ubiquitin ligase complex24076655
GO:0031462IDANOT colocalizes_withCul2-RING ubiquitin ligase complex27565346
GO:0031462IDAcolocalizes_withCul2-RING ubiquitin ligase complex24076655
GO:0031463IDAcolocalizes_withCul3-RING ubiquitin ligase complex24076655
GO:0031464IDAcolocalizes_withCul4A-RING E3 ubiquitin ligase complex24076655
GO:0097413IDA-Lewy body21590270
GO ID Evidence Qualifier GO_term References
GO:0004842IDA-ubiquitin-protein transferase activity14623119
GO:0004842TAS-ubiquitin-protein transferase activity-
GO:0005515IPI-protein binding10521492
GO:0008270IDA-zinc ion binding15236971
GO:0019787TAS-ubiquitin-like protein transferase activity10521492
GO:0031624IPI-ubiquitin conjugating enzyme binding23707686
GO:0031625IPI-ubiquitin protein ligase binding11278816
GO:0061630IBA-ubiquitin protein ligase activity-
GO ID Evidence Qualifier GO_term References
GO:0000209IBA-protein polyubiquitination-
GO:0006511TAS-ubiquitin-dependent protein catabolic process10521492
GO:0016567IDA-protein ubiquitination14623119
GO:0032436IBA-positive regulation of proteasomal ubiquitin-dependent protein catabolic process-
GO:0042787IBA-protein ubiquitination involved in ubiquitin-dependent protein catabolic process-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
ARIH1SIM211734815963499 Affinity Capture-Western
ARIH1SIM211238415963499 Affinity Capture-Western
ARIH1UBE2L311318010521492 11278816 14623119 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
ARIH1UBE2L311734810521492 11278816 14623119 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
ARIH1EIF4E211734814623119 Affinity Capture-Western; Two-hybrid
ARIH1EIF4E211485614623119 Affinity Capture-Western; Two-hybrid
ARIH1FBXW1111688719615732 Affinity Capture-MS
ARIH1FBXW1111734819615732 Affinity Capture-MS
Gene Symbol Interactant Interaction ID References Description
ARIH1UBE2L326217812234920 An unspecified isoform of UbcH7 interacts with Ari-1. This interaction was modeled on a demonstrated interaction between human UbcH7 and Drosophila melanogaster Ari-1.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1344363
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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