AutismKB 2.0

Annotation Details for PRKD2


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Basic Information Top
Gene Symbol:PRKD2 ( PKD2 )
Gene Full Name: protein kinase D2
Band: 19q13.2
Quick LinksEntrez ID:25865; OMIM: 607074; Uniprot ID:KPCD2_HUMAN; ENSEMBL ID: ENSG00000105287; HGNC ID: 17293
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus17077180
GO:0005654IDA-nucleoplasm-
GO:0005737IDA-cytoplasm17077180
GO:0005794IEA-Golgi apparatus-
GO:0005829IDA-cytosol-
GO:0005829TAS-cytosol-
GO:0005886IEA-plasma membrane-
GO ID Evidence Qualifier GO_term References
GO:0004672IDA-protein kinase activity17077180
GO:0004674IDA-protein serine/threonine kinase activity18440775
GO:0004674NAS-protein serine/threonine kinase activity11062248
GO:0004674TAS-protein serine/threonine kinase activity-
GO:0004697IEA-protein kinase C activity-
GO:0005515IPI-protein binding17962809
GO:0005524IEA-ATP binding-
GO:0046872IEA-metal ion binding-
GO ID Evidence Qualifier GO_term References
GO:0001525IEA-angiogenesis-
GO:0001938IGI-positive regulation of endothelial cell proliferation20497126
GO:0001938IMP-positive regulation of endothelial cell proliferation19001381
GO:0002250IEA-adaptive immune response-
GO:0006468IDA-protein phosphorylation22228765
GO:0006468NAS-protein phosphorylation11062248
GO:0007155IEA-cell adhesion-
GO:0008219IMP-cell death17077180
GO:0010595IMP-positive regulation of endothelial cell migration19001381
GO:0018105IDA-peptidyl-serine phosphorylation18440775
GO:0030148TAS-sphingolipid biosynthetic process-
GO:0030949IMP-positive regulation of vascular endothelial growth factor receptor signaling pathway19001381
GO:0032743ISS-positive regulation of interleukin-2 production-
GO:0032757IMP-positive regulation of interleukin-8 production16928771
GO:0032793IGI-positive regulation of CREB transcription factor activity20497126
GO:0033138IGI-positive regulation of peptidyl-serine phosphorylation20497126
GO:0035556IMP-intracellular signal transduction18059339
GO:0035924IGI-cellular response to vascular endothelial growth factor stimulus20497126
GO:0035924IMP-cellular response to vascular endothelial growth factor stimulus18059339
GO:0038033IGI-positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway20497126
GO:0038033IMP-positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway18440775
GO:0043536IGI-positive regulation of blood vessel endothelial cell migration20497126
GO:0043536IMP-positive regulation of blood vessel endothelial cell migration18440775
GO:0045743IMP-positive regulation of fibroblast growth factor receptor signaling pathway19001381
GO:0045766IGI-positive regulation of angiogenesis20497126
GO:0045766IMP-positive regulation of angiogenesis18440775
GO:0045785IMP-positive regulation of cell adhesion17951978
GO:0045944IDA-positive regulation of transcription from RNA polymerase II promoter17077180
GO:0045944IMP-positive regulation of transcription from RNA polymerase II promoter18059339
GO:0046777IDA-protein autophosphorylation17077180
GO:0046777TAS-protein autophosphorylation21488147
GO:0048010IMP-vascular endothelial growth factor receptor signaling pathway18059339
GO:0050852IDA-T cell receptor signaling pathway17077180
GO:0050862ISS-positive regulation of T cell receptor signaling pathway-
GO:0051091IMP-positive regulation of sequence-specific DNA binding transcription factor activity19192391
GO:0051092IMP-positive regulation of NF-kappaB transcription factor activity15604256
GO:0061154TAS-endothelial tube morphogenesis21488147
GO:0070374ISS-positive regulation of ERK1 and ERK2 cascade-
GO:0089700IGI-protein kinase D signaling20497126
GO:1901727IGI-positive regulation of histone deacetylase activity20497126
GO:1902533IMP-positive regulation of intracellular signal transduction18440775
GO:2000573ISS-positive regulation of DNA biosynthetic process-
GO:2001028IMP-positive regulation of endothelial cell chemotaxis18440775
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
PRKD2RAE111405419615732 Affinity Capture-MS
PRKD2RAE111738419615732 Affinity Capture-MS
HDAC7PRKD211961317962809 Affinity Capture-Western
HDAC7PRKD211738417962809 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:2141917
  • Data Attributes: HomoloGene calculated
No data