Gene Symbol:	POT1 ( DKFZp586D211,HPOT1 )
Gene Full Name:	protection of telomeres 1 homolog (S. pombe)
Band:	7q31.33
Quick Links	Entrez ID:25913; OMIM: 606478; Uniprot ID:POTE1_HUMAN; ENSEMBL ID: ENSG00000128513; HGNC ID: 17284
Relate to Another Database:	SFARIGene; denovo-db

GO ID	Evidence	Qualifier	GO_term	References
GO:0000781	IDA	-	chromosome, telomeric region	12768206
GO:0000783	IDA	-	nuclear telomere cap complex	16880378
GO:0000784	IDA	-	nuclear chromosome, telomeric region	19135898
GO:0005634	IDA	-	nucleus	-
GO:0005654	TAS	-	nucleoplasm	-
GO:0070187	IDA	-	shelterin complex	15383534
GO:0070187	IMP	-	shelterin complex	21852327
GO:0070187	TAS	-	shelterin complex	17237768

GO ID	Evidence	Qualifier	GO_term	References
GO:0005515	IPI	-	protein binding	12768206
GO:0010521	IDA	-	telomerase inhibitor activity	15632080
GO:0017151	IPI	-	DEAD/H-box RNA helicase binding	16030011
GO:0042162	IDA	-	telomeric DNA binding	23685356
GO:0043047	IDA	-	single-stranded telomeric DNA binding	15632080
GO:0043047	IMP	-	single-stranded telomeric DNA binding	12768206
GO:0061821	IDA	-	telomeric D-loop binding	19734539
GO:0061849	IDA	NOT	telomeric G-quadruplex DNA binding	19734539
GO:0098505	IDA	-	G-rich strand telomeric DNA binding	17237768
GO:1905773	IDA	-	8-hydroxy-2'-deoxyguanosine DNA binding	19734539
GO:1990955	IDA	-	G-rich single-stranded DNA binding	19734539

GO ID	Evidence	Qualifier	GO_term	References
GO:0007004	IDA	-	telomere maintenance via telomerase	12768206
GO:0016233	IGI	-	telomere capping	17632522
GO:0016233	IMP	-	telomere capping	15657433
GO:0016233	TAS	-	telomere capping	17237768
GO:0032202	IDA	-	telomere assembly	16043710
GO:0032210	IGI	-	regulation of telomere maintenance via telomerase	26586433
GO:0032211	IGI	-	negative regulation of telomere maintenance via telomerase	15181449
GO:0032211	TAS	-	negative regulation of telomere maintenance via telomerase	17237768
GO:0032212	IDA	-	positive regulation of telomere maintenance via telomerase	17237768
GO:0032212	IMP	-	positive regulation of telomere maintenance via telomerase	12768206
GO:0032508	IDA	-	DNA duplex unwinding	16030011
GO:0051096	IDA	-	positive regulation of helicase activity	16030011
GO:0051973	IDA	-	positive regulation of telomerase activity	16043710
GO:0051973	IMP	-	positive regulation of telomerase activity	15181449
GO:0051974	IDA	-	negative regulation of telomerase activity	15632080
GO:0060383	IDA	-	positive regulation of DNA strand elongation	16043710
GO:0061820	IGI	-	telomeric D-loop disassembly	22039056
GO:0070200	IMP	-	establishment of protein localization to telomere	25589350
GO:1905774	IDA	-	regulation of DNA helicase activity	19734539
GO:1905776	IDA	-	positive regulation of DNA helicase activity	19734539

Gene Symbol	Interactant	Interaction ID	References	Description
POT1	TERF1	112872	12768206	Affinity Capture-Western
POT1	TERF1	117417	12768206	Affinity Capture-Western
POT1	WRN	113323	21098121	Phenotypic Enhancement
POT1	WRN	117417	21098121	Phenotypic Enhancement
POT1	TNKS	114207	12768206	Affinity Capture-Western
POT1	TNKS	117417	12768206	Affinity Capture-Western
TINF2	POT1	117660	12768206 15181449 15231715	Affinity Capture-MS; Affinity Capture-Western
TINF2	POT1	117417	12768206 15181449 15231715	Affinity Capture-MS; Affinity Capture-Western
ACD	POT1	122379	15181449 15231715 16189514	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
ACD	POT1	117417	15181449 15231715 16189514	Affinity Capture-Western; Reconstituted Complex; Two-hybrid

AutismKB 2.0

Annotation Details for POT1