AutismKB 2.0

Annotation Details for SIN3A


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Basic Information Top
Gene Symbol:SIN3A ( DKFZp434K2235,FLJ90319,KIAA0700 )
Gene Full Name: SIN3 homolog A, transcription regulator (yeast)
Band: 15q24.2
Quick LinksEntrez ID:25942; OMIM: 607776; Uniprot ID:SIN3A_HUMAN; ENSEMBL ID: ENSG00000169375; HGNC ID: 19353
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000776IEA-kinetochore-
GO:0005634IDA-nucleus22783022
GO:0005634ISS-nucleus-
GO:0005654IDA-nucleoplasm-
GO:0005654TAS-nucleoplasm-
GO:0005667IEA-transcription factor complex-
GO:0005730IEA-nucleolus-
GO:0016580IDA-Sin3 complex14966270
GO:0016580NAS-Sin3 complex22783022
GO:0017053IEA-transcriptional repressor complex-
GO ID Evidence Qualifier GO_term References
GO:0000976ISS-transcription regulatory region sequence-specific DNA binding-
GO:0001102IPI-RNA polymerase II activating transcription factor binding22783022
GO:0001103IEA-RNA polymerase II repressing transcription factor binding-
GO:0001106IBA-RNA polymerase II transcription corepressor activity-
GO:0003682IEA-chromatin binding-
GO:0003700IEA-transcription factor activity, sequence-specific DNA binding-
GO:0003723IEA-RNA binding-
GO:0004407IBAcontributes_tohistone deacetylase activity-
GO:0005515IPI-protein binding10049357
GO:0032403IEA-protein complex binding-
GO:0033558IMP-protein deacetylase activity22783022
GO ID Evidence Qualifier GO_term References
GO:0000122IMP-negative regulation of transcription from RNA polymerase II promoter22783022
GO:0001701IEA-in utero embryonic development-
GO:0002218IMP-activation of innate immune response22783022
GO:0002230IMP-positive regulation of defense response to virus by host22783022
GO:0002244IEA-hematopoietic progenitor cell differentiation-
GO:0006260IEA-DNA replication-
GO:0006351IEA-transcription, DNA-templated-
GO:0006476IMP-protein deacetylation22783022
GO:0007568IEA-aging-
GO:0010817IEA-regulation of hormone levels-
GO:0010971IEA-positive regulation of G2/M transition of mitotic cell cycle-
GO:0016575IBA-histone deacetylation-
GO:0019216TAS-regulation of lipid metabolic process-
GO:0031937IMP-positive regulation of chromatin silencing22783022
GO:0034613IEA-cellular protein localization-
GO:0042754ISS-negative regulation of circadian rhythm-
GO:0043066IEA-negative regulation of apoptotic process-
GO:0043619IEA-regulation of transcription from RNA polymerase II promoter in response to oxidative stress-
GO:0045892ISS-negative regulation of transcription, DNA-templated-
GO:0045944IMP-positive regulation of transcription from RNA polymerase II promoter22783022
GO:0048511IEA-rhythmic process-
GO:0051595IEA-response to methylglyoxal-
GO:0071333IEA-cellular response to glucose stimulus-
GO:1900181IMP-negative regulation of protein localization to nucleus22783022
GO:1901675IMP-negative regulation of histone H3-K27 acetylation22783022
GO:1903351IEA-cellular response to dopamine-
GO:2000678IMP-negative regulation of transcription regulatory region DNA binding22783022
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
SIN3AADD110663117074803 Affinity Capture-Western
SIN3AADD111743917074803 Affinity Capture-Western
SIN3ANKX3-210705514612411 Affinity Capture-Western
SIN3ANKX3-211743914612411 Affinity Capture-Western
SIN3ABCL61070769753732 9765306 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SIN3ABCL61174399753732 9765306 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SIN3AKLF911743911438660 Reconstituted Complex
SIN3AKLF910715211438660 Reconstituted Complex
SIN3ARUNX110730914729951 Affinity Capture-Western
SIN3ARUNX111743914729951 Affinity Capture-Western
SIN3ARUNX1T110731011150306 15333839 16227606 Affinity Capture-Western; Reconstituted Complex
SIN3ARUNX1T111743911150306 15333839 16227606 Affinity Capture-Western; Reconstituted Complex
SIN3ACHD311743912453419 Affinity Capture-Western
SIN3ACHD310753212453419 Affinity Capture-Western
SIN3ACHD41174399790534 Affinity Capture-MS
SIN3ACHD41075339790534 Affinity Capture-MS
SIN3ACSNK2A110784117827154 Affinity Capture-Western
SIN3ACSNK2A111743917827154 Affinity Capture-Western
SIN3ADNMT3B10812615148359 Co-purification
SIN3ADNMT3B11743915148359 Co-purification
SIN3AESR110840319620290 Affinity Capture-Western
SIN3AESR111743919620290 Affinity Capture-Western
SIN3AETV611743911439334 Affinity Capture-Western
SIN3AETV610842111439334 Affinity Capture-Western
SIN3AGPS210913217210713 Affinity Capture-Western
SIN3AGPS211743917210713 Affinity Capture-Western
SIN3AHCFC111743912670868 15199122 20126307 Affinity Capture-MS; Affinity Capture-Western; Two-hybrid
SIN3AHCFC110930412670868 15199122 20126307 Affinity Capture-MS; Affinity Capture-Western; Two-hybrid
SIN3AHDAC11093159520398 9790534 9804427 10220385 10444591 10640275 11102443 11118440 11171972 11602581 11784859 11931768 12091390 12374985 12398767 12453419 12724404 12920132 12943729 14593184 14647463 15695521 16331260 17643391 17827154 18059533 Affinity Capture-MS; Affinity Capture-Western; Co-fractionation; Co-purification; Reconstituted Complex
SIN3AHDAC11174399520398 9790534 9804427 10220385 10444591 10640275 11102443 11118440 11171972 11602581 11784859 11931768 12091390 12374985 12398767 12453419 12724404 12920132 12943729 14593184 14647463 15695521 16331260 17643391 17827154 18059533 Affinity Capture-MS; Affinity Capture-Western; Co-fractionation; Co-purification; Reconstituted Complex
SIN3AHDAC21093169150134 9804427 12091390 12398767 12453419 12493763 12724404 12943729 14749338 16254079 17827154 18059533 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
SIN3AHDAC21174399150134 9804427 12091390 12398767 12453419 12493763 12724404 12943729 14749338 16254079 17827154 18059533 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
SIN3AHSP90AA110955217210713 Affinity Capture-Western
SIN3AHSP90AA111743917210713 Affinity Capture-Western
SIN3AID211743916776654 Affinity Capture-Western
SIN3AID210962416776654 Affinity Capture-Western
SIN3ARBPJ10973610644367 Reconstituted Complex
SIN3ARBPJ11743910644367 Reconstituted Complex
SIN3AING110983311118440 11784859 Affinity Capture-MS; Affinity Capture-Western
SIN3AING111743911118440 11784859 Affinity Capture-MS; Affinity Capture-Western
SIN3AING210983416387653 16728974 Affinity Capture-MS; Affinity Capture-Western
SIN3AING211743916387653 16728974 Affinity Capture-MS; Affinity Capture-Western
SIN3AMXD11102597889570 11106735 15235594 Co-crystal Structure; Reconstituted Complex
SIN3AMXD11174397889570 11106735 15235594 Co-crystal Structure; Reconstituted Complex
SIN3ASMAD311743911306568 Reconstituted Complex
SIN3ASMAD311026311306568 Reconstituted Complex
SIN3AMECP21174399620779 9620804 10773092 14593184 15322089 Affinity Capture-Western; Reconstituted Complex
SIN3AMECP21103689620779 9620804 10773092 14593184 15322089 Affinity Capture-Western; Reconstituted Complex
SIN3AMEN111743914559791 Affinity Capture-Western; Reconstituted Complex
SIN3AMEN111038414559791 Affinity Capture-Western; Reconstituted Complex
SIN3AMNT1174399184233 Reconstituted Complex; Two-hybrid
SIN3AMNT1104789184233 Reconstituted Complex; Two-hybrid
SIN3AMYB11743914761981 Affinity Capture-Western; Reconstituted Complex
SIN3AMYB11068714761981 Affinity Capture-Western; Reconstituted Complex
SIN3ANFX111086518505829 Affinity Capture-Western; Reconstituted Complex
SIN3ANFX111743918505829 Affinity Capture-Western; Reconstituted Complex
SIN3ANKX2-211743915695521 Affinity Capture-Western
SIN3ANKX2-211088615695521 Affinity Capture-Western
SIN3ANR4A211098319144721 Affinity Capture-Western
SIN3ANR4A211743919144721 Affinity Capture-Western
SIN3APA2G411743916254079 Affinity Capture-Western; Reconstituted Complex
SIN3APA2G411107516254079 Affinity Capture-Western; Reconstituted Complex
SIN3APFDN511122611585818 Affinity Capture-Western
SIN3APFDN511743911585818 Affinity Capture-Western
SIN3APFN211123812391155 Affinity Capture-Western
SIN3APFN211743912391155 Affinity Capture-Western
SIN3APHB11126412466959 Affinity Capture-Western
SIN3APHB11743912466959 Affinity Capture-Western
SIN3APML11138411430826 Affinity Capture-Western; Reconstituted Complex
SIN3APML11743911430826 Affinity Capture-Western; Reconstituted Complex
SIN3APTMA11172412634383 Reconstituted Complex
SIN3APTMA11743912634383 Reconstituted Complex
SIN3ARAN11183712453419 Affinity Capture-Western
SIN3ARAN11743912453419 Affinity Capture-Western
SIN3AARID4A11186111283269 Affinity Capture-Western
SIN3AARID4A11743911283269 Affinity Capture-Western
SIN3ARBBP41118639150133 9651585 11118440 11602581 12453419 Affinity Capture-Western; Reconstituted Complex
SIN3ARBBP41174399150133 9651585 11118440 11602581 12453419 Affinity Capture-Western; Reconstituted Complex
SIN3ARBBP71174399651585 11784859 12453419 Affinity Capture-Western; Reconstituted Complex
SIN3ARBBP71118669651585 11784859 12453419 Affinity Capture-Western; Reconstituted Complex
SIN3AREST11191010491605 Affinity Capture-Western
SIN3AREST11743910491605 Affinity Capture-Western
SIN3ASATB111743912374985 Co-fractionation
SIN3ASATB111221112374985 Co-fractionation
SIN3ASFPQ11743917452459 19339282 Affinity Capture-Western; Co-localization
SIN3ASFPQ11231917452459 19339282 Affinity Capture-Western; Co-localization
SIN3ASKI11238811430826 Reconstituted Complex
SIN3ASKI11743911430826 Reconstituted Complex
SIN3ASKIL11238910049357 Affinity Capture-Western
SIN3ASKIL11743910049357 Affinity Capture-Western
SIN3ASMARCA211743911238380 12453419 14559996 15314177 Affinity Capture-Western; Co-purification; Reconstituted Complex
SIN3ASMARCA211247911238380 12453419 14559996 15314177 Affinity Capture-Western; Co-purification; Reconstituted Complex
SIN3ASMARCA411743911238380 11784859 14559996 16800816 19081374 Affinity Capture-Western; Co-purification; Reconstituted Complex
SIN3ASMARCA411248111238380 11784859 14559996 16800816 19081374 Affinity Capture-Western; Co-purification; Reconstituted Complex
SIN3ASMARCB111743911238380 12453419 14559996 Affinity Capture-Western; Co-purification; Reconstituted Complex
SIN3ASMARCB111248211238380 12453419 14559996 Affinity Capture-Western; Co-purification; Reconstituted Complex
SIN3ASMARCC111248311238380 11784859 12453419 Affinity Capture-Western; Reconstituted Complex
SIN3ASMARCC111743911238380 11784859 12453419 Affinity Capture-Western; Reconstituted Complex
SIN3ASMARCC211743912453419 Affinity Capture-Western
SIN3ASMARCC211248512453419 Affinity Capture-Western
SIN3ASMARCE111248914559996 Reconstituted Complex
SIN3ASMARCE111743914559996 Reconstituted Complex
SIN3ASMN111249014749338 Affinity Capture-Western
SIN3ASMN111743914749338 Affinity Capture-Western
SIN3ASP111255015528196 Affinity Capture-Western
SIN3ASP111743915528196 Affinity Capture-Western
SIN3ASPI111743911593411 Affinity Capture-Western; Reconstituted Complex
SIN3ASPI111256611593411 Affinity Capture-Western; Reconstituted Complex
SIN3ASYT111743915467731 Reconstituted Complex; Two-hybrid
SIN3ASYT111272315467731 Reconstituted Complex; Two-hybrid
SIN3ATAF111273512453419 Affinity Capture-Western
SIN3ATAF111743912453419 Affinity Capture-Western
SIN3ATAF611743912453419 Affinity Capture-Western
SIN3ATAF611274112453419 Affinity Capture-Western
SIN3ATAF911743912453419 Affinity Capture-Western
SIN3ATAF911274312453419 Affinity Capture-Western
SIN3ATAL111274910688671 Affinity Capture-Western; Reconstituted Complex
SIN3ATAL111743910688671 Affinity Capture-Western; Reconstituted Complex
SIN3ATBL1X11743917210713 Affinity Capture-Western
SIN3ATBL1X11277017210713 Affinity Capture-Western
SIN3ATBP11743912453419 Affinity Capture-Western
SIN3ATBP11277112453419 Affinity Capture-Western
SIN3ATCF311743915934135 16252006 Affinity Capture-Western
SIN3ATCF311279115934135 16252006 Affinity Capture-Western
SIN3ATFCP211743911884454 Reconstituted Complex
SIN3ATFCP211288211884454 Reconstituted Complex
SIN3ATGIF111290811682623 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SIN3ATGIF111743911682623 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SIN3AKLF1011743911438660 Reconstituted Complex
SIN3AKLF1011292711438660 Reconstituted Complex
SIN3ATP5311301010521394 Affinity Capture-Western; Reconstituted Complex
SIN3ATP5311743910521394 Affinity Capture-Western; Reconstituted Complex
SIN3AVDR11326416252006 Affinity Capture-Western
SIN3AVDR11743916252006 Affinity Capture-Western
SIN3AWHSC111330618156491 Affinity Capture-Western
SIN3AWHSC111743918156491 Affinity Capture-Western
SIN3AZBTB161134989627120 9765306 11719366 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SIN3AZBTB161174399627120 9765306 11719366 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SIN3ANR0B211401215314177 17210713 Affinity Capture-Western; Reconstituted Complex
SIN3ANR0B211743915314177 17210713 Affinity Capture-Western; Reconstituted Complex
SIN3AKLF1111404011438660 12006497 Affinity Capture-Western; Reconstituted Complex
SIN3AKLF1111743911438660 12006497 Affinity Capture-Western; Reconstituted Complex
SIN3ASMARCA511743918535655 Affinity Capture-Western
SIN3ASMARCA511404518535655 Affinity Capture-Western
SIN3AOGT11743912150998 16505006 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SIN3AOGT11404912150998 16505006 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SIN3ASAP301143469651585 9702189 9790534 10444591 11118440 11283269 11390640 11784859 12453419 12724404 16820529 Affinity Capture-MS; Affinity Capture-Western; Co-purification; Reconstituted Complex
SIN3ASAP301174399651585 9702189 9790534 10444591 11118440 11283269 11390640 11784859 12453419 12724404 16820529 Affinity Capture-MS; Affinity Capture-Western; Co-purification; Reconstituted Complex
SIN3AMBD411444415899845 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SIN3AMBD411743915899845 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SIN3AMBD211444510950960 Reconstituted Complex; Two-hybrid
SIN3AMBD211743910950960 Reconstituted Complex; Two-hybrid
SIN3ABAZ1B11449716252006 Affinity Capture-Western
SIN3ABAZ1B11743916252006 Affinity Capture-Western
SIN3AMTA111456212920132 Affinity Capture-MS
SIN3AMTA111743912920132 Affinity Capture-MS
SIN3ACBFA2T211458616227606 Affinity Capture-Western
SIN3ACBFA2T211743916227606 Affinity Capture-Western
SIN3AMTA211743911602581 12920132 Affinity Capture-MS; Affinity Capture-Western
SIN3AMTA211465211602581 12920132 Affinity Capture-MS; Affinity Capture-Western
SIN3ACOPS211743910207062 15173382 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SIN3ACOPS211472910207062 15173382 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SIN3ANCOR111497311430826 17210713 Affinity Capture-Western; Reconstituted Complex
SIN3ANCOR111743911430826 17210713 Affinity Capture-Western; Reconstituted Complex
SIN3ANCOR211743910640275 10944117 Co-fractionation; Reconstituted Complex
SIN3ANCOR211497410640275 10944117 Co-fractionation; Reconstituted Complex
SIN3AMORF4L211743912391155 Affinity Capture-Western
SIN3AMORF4L211500112391155 Affinity Capture-Western
SIN3AHDAC911508311959865 12590135 Affinity Capture-Western; Reconstituted Complex
SIN3AHDAC911743911959865 12590135 Affinity Capture-Western; Reconstituted Complex
SIN3AHDAC411510617011572 17210713 Affinity Capture-Western
SIN3AHDAC411743917011572 17210713 Affinity Capture-Western
SIN3ASETDB111520212398767 Affinity Capture-Western
SIN3ASETDB111743912398767 Affinity Capture-Western
SIN3AHDAC511533117011572 Affinity Capture-Western
SIN3AHDAC511743917011572 Affinity Capture-Western
SIN3ATRIM2811545714761981 Reconstituted Complex
SIN3ATRIM2811743914761981 Reconstituted Complex
SIN3ATOPORS11743917803295 Affinity Capture-MS; Biochemical Activity
SIN3ATOPORS11550517803295 Affinity Capture-MS; Biochemical Activity
SIN3ASAP181174399651585 Reconstituted Complex
SIN3ASAP181155739651585 Reconstituted Complex
SIN3AIKZF111743910357820 11959865 12015313 Affinity Capture-Western
SIN3AIKZF111560410357820 11959865 12015313 Affinity Capture-Western
SIN3APRMT511743914559996 Affinity Capture-Western; Reconstituted Complex
SIN3APRMT511568814559996 Affinity Capture-Western; Reconstituted Complex
SIN3AKLF111743915542849 Affinity Capture-Western
SIN3AKLF111590415542849 Affinity Capture-Western
SIN3ACTCF11743910734189 Reconstituted Complex
SIN3ACTCF11590610734189 Reconstituted Complex
SIN3AMGEA511594816505006 Affinity Capture-Western
SIN3AMGEA511743916505006 Affinity Capture-Western
SIN3AMORF411613512391155 Affinity Capture-Western
SIN3AMORF411743912391155 Affinity Capture-Western
SIN3AIKZF311648412015313 Affinity Capture-Western
SIN3AIKZF311743912015313 Affinity Capture-Western
SIN3AIKZF211648512015313 Affinity Capture-Western
SIN3AIKZF211743912015313 Affinity Capture-Western
SIN3ASNW111659710644367 Reconstituted Complex
SIN3ASNW111743910644367 Reconstituted Complex
SIN3AKDM1A11743911171972 Affinity Capture-Western
SIN3AKDM1A11666711171972 Affinity Capture-Western
SIN3AHEY211704511486045 Affinity Capture-Western
SIN3AHEY211743911486045 Affinity Capture-Western
SIN3ACABIN111707010933397 Affinity Capture-Western; Reconstituted Complex
SIN3ACABIN111743910933397 Affinity Capture-Western; Reconstituted Complex
MXD3SIN3A1174399184233 Two-hybrid
MXD3SIN3A1236589184233 Two-hybrid
RLIMSIN3A11931910431247 Affinity Capture-Western
RLIMSIN3A11743910431247 Affinity Capture-Western
STRA13SIN3A12837610737769 Reconstituted Complex
STRA13SIN3A11743910737769 Reconstituted Complex
PHF12SIN3A12168611390640 21440557 Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex; Two-hybrid
PHF12SIN3A11743911390640 21440557 Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex; Two-hybrid
KLF16SIN3A11743911438660 12036432 Affinity Capture-Western; Reconstituted Complex
KLF16SIN3A12377111438660 12036432 Affinity Capture-Western; Reconstituted Complex
KLF13SIN3A11743911438660 Reconstituted Complex
KLF13SIN3A11964211438660 Reconstituted Complex
SUDS3SIN3A12217411909966 12724404 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SUDS3SIN3A11743911909966 12724404 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
IKZF4SIN3A11743912015313 Affinity Capture-Western
IKZF4SIN3A12214612015313 Affinity Capture-Western
ALL1SIN3A114743012453419 Affinity Capture-Western
ALL1SIN3A11743912453419 Affinity Capture-Western
MBD3SIN3A11743912453419 Affinity Capture-Western
MBD3SIN3A11978812453419 Affinity Capture-Western
EFCAB6SIN3A12230612612053 Affinity Capture-Western
EFCAB6SIN3A11743912612053 Affinity Capture-Western
BCL6BSIN3A12912512659862 Two-hybrid
BCL6BSIN3A11743912659862 Two-hybrid
ARID4BSIN3A11970812724404 Affinity Capture-MS; Affinity Capture-Western
ARID4BSIN3A11743912724404 Affinity Capture-MS; Affinity Capture-Western
SAP130SIN3A12273512724404 Affinity Capture-MS; Affinity Capture-Western
SAP130SIN3A11743912724404 Affinity Capture-MS; Affinity Capture-Western
HBP1SIN3A11792715235594 Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex; Two-hybrid
HBP1SIN3A11743915235594 Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex; Two-hybrid
MBD3L1SIN3A12456915456747 Affinity Capture-Western
MBD3L1SIN3A11743915456747 Affinity Capture-Western
CYP4V2SIN3A13011316030350 Affinity Capture-Western
CYP4V2SIN3A11743916030350 Affinity Capture-Western
SAP25SIN3A11743916449650 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
SAP25SIN3A94101816449650 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
SAP30LSIN3A11743916820529 18070604 Affinity Capture-Western; Reconstituted Complex
SAP30LSIN3A12280816820529 18070604 Affinity Capture-Western; Reconstituted Complex
ZBTB4SIN3A12169318451802 Affinity Capture-Western
ZBTB4SIN3A11743918451802 Affinity Capture-Western
MKXSIN3A11743919235719 Affinity Capture-Western
MKXSIN3A12945319235719 Affinity Capture-Western
ZBTB7ASIN3A11948819244234 Affinity Capture-Western
ZBTB7ASIN3A11743919244234 Affinity Capture-Western
Gene Symbol Interactant Interaction ID References Description
SIN3AHTT12818810823891 mSin3A interacts with htt. This interaction was modeled on a demonstrated interaction between mSin3A and htt from unspecified species.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:107157
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030131-2066'