Gene Symbol:	APPL1 ( APPL,DIP13alpha )
Gene Full Name:	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
Band:	3p14.3
Quick Links	Entrez ID:26060; OMIM: 604299; Uniprot ID:DP13A_HUMAN; ENSEMBL ID: ENSG00000157500; HGNC ID: 24035
Relate to Another Database:	SFARIGene; denovo-db

GO ID	Evidence	Qualifier	GO_term	References
GO:0005634	IDA	-	nucleus	15016378
GO:0005737	IC	-	cytoplasm	10490823
GO:0005769	ISS	-	early endosome	-
GO:0005829	IDA	-	cytosol	17848569
GO:0010008	IDA	-	endosome membrane	15016378
GO:0010008	TAS	-	endosome membrane	-
GO:0012506	IDA	-	vesicle membrane	17848569
GO:0016581	IDA	colocalizes_with	NuRD complex	15016378
GO:0031901	IEA	-	early endosome membrane	-
GO:0070062	IDA	-	extracellular exosome	18570454

GO ID	Evidence	Qualifier	GO_term	References
GO:0005515	IPI	-	protein binding	10490823
GO:0042802	IPI	-	identical protein binding	17581628
GO:0043422	IPI	-	protein kinase B binding	17848569

GO ID	Evidence	Qualifier	GO_term	References
GO:0007049	IEA	-	cell cycle	-
GO:0007165	TAS	-	signal transduction	10490823
GO:0008283	IDA	-	cell proliferation	15016378
GO:0008286	IMP	-	insulin receptor signaling pathway	26073777
GO:0008286	TAS	-	insulin receptor signaling pathway	17848569
GO:0046324	IMP	-	regulation of glucose import	17848569
GO:0090003	IMP	-	regulation of establishment of protein localization to plasma membrane	17848569
GO:0097192	TAS	-	extrinsic apoptotic signaling pathway in absence of ligand	-

Gene Symbol	Interactant	Interaction ID	References	Description
APPL1	AKT2	117522	10490823	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
APPL1	AKT2	106711	10490823	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
APPL1	DCC	117522	12011067	Affinity Capture-Western; Two-hybrid
APPL1	DCC	107998	12011067	Affinity Capture-Western; Two-hybrid
APPL1	HDAC1	109315	19686092	Affinity Capture-Western; Reconstituted Complex
APPL1	HDAC1	117522	19686092	Affinity Capture-Western; Reconstituted Complex
APPL1	HDAC2	117522	19686092	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
APPL1	HDAC2	109316	19686092	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
APPL1	RBBP4	111863	19686092	Affinity Capture-Western
APPL1	RBBP4	117522	19686092	Affinity Capture-Western
APPL1	RBBP7	117522	19686092	Affinity Capture-Western
APPL1	RBBP7	111866	19686092	Affinity Capture-Western
APPL1	TRAF2	113038	16189514	Two-hybrid
APPL1	TRAF2	117522	16189514	Two-hybrid
APPL1	MTA2	117522	19686092	Affinity Capture-Western
APPL1	MTA2	114652	19686092	Affinity Capture-Western
APPL1	RUVBL2	117522	19433865	Affinity Capture-Western; Reconstituted Complex
APPL1	RUVBL2	116067	19433865	Affinity Capture-Western; Reconstituted Complex
APPL2	APPL1	117522	16189514	Two-hybrid
APPL2	APPL1	120495	16189514	Two-hybrid

AutismKB 2.0

Annotation Details for APPL1