AutismKB 2.0

Annotation Details for GARS


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:GARS ( CMT2D,DSMAV,GlyRS,HMN5,SMAD1 )
Gene Full Name: glycyl-tRNA synthetase
Band: 7p14.3
Quick LinksEntrez ID:2617; OMIM: 600287; Uniprot ID:SYG_HUMAN; ENSEMBL ID: ENSG00000106105; HGNC ID: 4162
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005737IBA-cytoplasm-
GO:0005759TAS-mitochondrial matrix-
GO:0005829IDA-cytosol-
GO:0005829TAS-cytosol-
GO:0030141IEA-secretory granule-
GO:0030424IDA-axon17035524
GO:0070062IDA-extracellular exosome23376485
GO:0070062ISS-extracellular exosome-
GO ID Evidence Qualifier GO_term References
GO:0004081IDA-bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity19710017
GO:0004820IDA-glycine-tRNA ligase activity17544401
GO:0004820TAS-glycine-tRNA ligase activity-
GO:0005524IEA-ATP binding-
GO:0046983IDA-protein dimerization activity17544401
GO ID Evidence Qualifier GO_term References
GO:0006418TAS-tRNA aminoacylation for protein translation-
GO:0006426IBA-glycyl-tRNA aminoacylation-
GO:0015966IDA-diadenosine tetraphosphate biosynthetic process19710017
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
GARSEEF1D10888711829477 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
GARSEEF1D10825611829477 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
IARSGARS1088878816763 Two-hybrid
IARSGARS1096058816763 Two-hybrid
Gene Symbol Interactant Interaction ID References Description
GARSEEF1D29491211829477 GRS interacts with an unspecified isoform of EF-1-delta.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:2449057
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018