AutismKB 2.0

Annotation Details for GATA3


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Basic Information Top
Gene Symbol:GATA3 ( HDR,MGC2346,MGC5199,MGC5445 )
Gene Full Name: GATA binding protein 3
Band: 10p14
Quick LinksEntrez ID:2625; OMIM: 131320; Uniprot ID:GATA3_HUMAN; ENSEMBL ID: ENSG00000107485; HGNC ID: 4172
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000790IDA-nuclear chromatin20855495
GO:0005634IDA-nucleus19674970
GO:0005654IDA-nucleoplasm-
GO:0005654TAS-nucleoplasm-
GO:0005667IBA-transcription factor complex-
GO ID Evidence Qualifier GO_term References
GO:0000976IDA-transcription regulatory region sequence-specific DNA binding19723756
GO:0000977IBA-RNA polymerase II regulatory region sequence-specific DNA binding-
GO:0000979IEA-RNA polymerase II core promoter sequence-specific DNA binding-
GO:0000987IDA-core promoter proximal region sequence-specific DNA binding19232384
GO:0001046IDA-core promoter sequence-specific DNA binding19674970
GO:0001071IDA-nucleic acid binding transcription factor activity19232384
GO:0001071IMP-nucleic acid binding transcription factor activity19674970
GO:0001077IEA-transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding-
GO:0001078IMP-transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding19674970
GO:0001085IBA-RNA polymerase II transcription factor binding-
GO:0001158IEA-enhancer sequence-specific DNA binding-
GO:0001228IBA-transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding-
GO:0003677TAS-DNA binding1871134
GO:0003682IBA-chromatin binding-
GO:0003700TAS-transcription factor activity, sequence-specific DNA binding2050118
GO:0003713IDA-transcription coactivator activity20484083
GO:0005134IEA-interleukin-2 receptor binding-
GO:0005515IPI-protein binding19674970
GO:0008134IPI-transcription factor binding15016828
GO:0008270IEA-zinc ion binding-
GO:0044212IDA-transcription regulatory region DNA binding19735555
GO:0046983IEA-protein dimerization activity-
GO:0070888IDA-E-box binding20855495
GO:0071837IPI-HMG box domain binding18445004
GO ID Evidence Qualifier GO_term References
GO:0000122IEA-negative regulation of transcription from RNA polymerase II promoter-
GO:0001701IEA-in utero embryonic development-
GO:0001709ISS-cell fate determination-
GO:0001764IEA-neuron migration-
GO:0001806IEA-type IV hypersensitivity-
GO:0001822IMP-kidney development19248180
GO:0001823ISS-mesonephros development-
GO:0002088IEA-lens development in camera-type eye-
GO:0002572IEA-pro-T cell differentiation-
GO:0003180ISS-aortic valve morphogenesis-
GO:0003215ISS-cardiac right ventricle morphogenesis-
GO:0003281ISS-ventricular septum development-
GO:0006338IEA-chromatin remodeling-
GO:0006366TAS-transcription from RNA polymerase II promoter1871134
GO:0006952TAS-defense response7592673
GO:0006959IEA-humoral immune response-
GO:0007165ISS-signal transduction-
GO:0007411IEA-axon guidance-
GO:0007596TAS-blood coagulation-
GO:0008285ISS-negative regulation of cell proliferation-
GO:0008584ISS-male gonad development-
GO:0009615IEP-response to virus20583921
GO:0009653TAS-anatomical structure morphogenesis10935639
GO:0009791IEA-post-embryonic development-
GO:0009967IMP-positive regulation of signal transduction19674970
GO:0010332IEA-response to gamma radiation-
GO:0010595IMP-positive regulation of endothelial cell migration19674970
GO:0010975IEA-regulation of neuron projection development-
GO:0014065ISS-phosphatidylinositol 3-kinase signaling-
GO:0016579TAS-protein deubiquitination-
GO:0030218IEA-erythrocyte differentiation-
GO:0031929ISS-TOR signaling-
GO:0032689IEA-negative regulation of interferon-gamma production-
GO:0032703IEA-negative regulation of interleukin-2 production-
GO:0032753ISS-positive regulation of interleukin-4 production-
GO:0033600IDA-negative regulation of mammary gland epithelial cell proliferation19483726
GO:0035162IEA-embryonic hemopoiesis-
GO:0035457IEP-cellular response to interferon-alpha20554961
GO:0035799IEA-ureter maturation-
GO:0035898IEA-parathyroid hormone secretion-
GO:0042035ISS-regulation of cytokine biosynthetic process-
GO:0042421ISS-norepinephrine biosynthetic process-
GO:0042472IEA-inner ear morphogenesis-
GO:0042493IEA-response to drug-
GO:0043370IEA-regulation of CD4-positive, alpha-beta T cell differentiation-
GO:0043523IEA-regulation of neuron apoptotic process-
GO:0043583IMP-ear development19248180
GO:0043627IEP-response to estrogen10037815
GO:0045061IEA-thymic T cell selection-
GO:0045064IEA-T-helper 2 cell differentiation-
GO:0045087IEA-innate immune response-
GO:0045471IEA-response to ethanol-
GO:0045582ISS-positive regulation of T cell differentiation-
GO:0045599IMP-negative regulation of fat cell differentiation20705609
GO:0045786IMP-negative regulation of cell cycle20189993
GO:0045892IMP-negative regulation of transcription, DNA-templated19674970
GO:0045893IDA-positive regulation of transcription, DNA-templated19723756
GO:0045893IMP-positive regulation of transcription, DNA-templated19674970
GO:0045893ISS-positive regulation of transcription, DNA-templated-
GO:0045944IDA-positive regulation of transcription from RNA polymerase II promoter19232384
GO:0045944IMP-positive regulation of transcription from RNA polymerase II promoter20855495
GO:0045944ISS-positive regulation of transcription from RNA polymerase II promoter-
GO:0048469IEA-cell maturation-
GO:0048485ISS-sympathetic nervous system development-
GO:0048538IEA-thymus development-
GO:0048589IEA-developmental growth-
GO:0048646ISS-anatomical structure formation involved in morphogenesis-
GO:0050728IMP-negative regulation of inflammatory response19674970
GO:0050852ISS-T cell receptor signaling pathway-
GO:0051569IEA-regulation of histone H3-K4 methylation-
GO:0051897IMP-positive regulation of protein kinase B signaling19674970
GO:0060017IEA-parathyroid gland development-
GO:0060037ISS-pharyngeal system development-
GO:0060065ISS-uterus development-
GO:0060231IDA-mesenchymal to epithelial transition20189993
GO:0060374IEA-mast cell differentiation-
GO:0060676ISS-ureteric bud formation-
GO:0061085IEA-regulation of histone H3-K27 methylation-
GO:0061290ISS-canonical Wnt signaling pathway involved in metanephric kidney development-
GO:0071353IEP-cellular response to interleukin-420554961
GO:0071356IEP-cellular response to tumor necrosis factor19674970
GO:0071442IEA-positive regulation of histone H3-K14 acetylation-
GO:0071599IEA-otic vesicle development-
GO:0071773IEA-cellular response to BMP stimulus-
GO:0072107ISS-positive regulation of ureteric bud formation-
GO:0072178ISS-nephric duct morphogenesis-
GO:0072179ISS-nephric duct formation-
GO:0072182ISS-regulation of nephron tubule epithelial cell differentiation-
GO:0072602IEA-interleukin-4 secretion-
GO:0072643IEA-interferon-gamma secretion-
GO:0072676IDA-lymphocyte migration19805038
GO:0090102IEA-cochlea development-
GO:1901536IEA-negative regulation of DNA demethylation-
GO:2000114IEA-regulation of establishment of cell polarity-
GO:2000146IMP-negative regulation of cell motility20189993
GO:2000352IMP-negative regulation of endothelial cell apoptotic process19674970
GO:2000553IEA-positive regulation of T-helper 2 cell cytokine production-
GO:2000607ISS-negative regulation of cell proliferation involved in mesonephros development-
GO:2000611IMP-positive regulation of thyroid hormone generation19248180
GO:2000617IEA-positive regulation of histone H3-K9 acetylation-
GO:2000664IDA-positive regulation of interleukin-5 secretion20554961
GO:2000667IDA-positive regulation of interleukin-13 secretion20554961
GO:2000667IMP-positive regulation of interleukin-13 secretion20368097
GO:2000679IMP-positive regulation of transcription regulatory region DNA binding20368097
GO:2000683IMP-regulation of cellular response to X-ray19735555
GO:2000703ISS-negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation-
GO:2000734ISS-negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
GATA3BMI110889517114435 Affinity Capture-Western
GATA3BMI110711617114435 Affinity Capture-Western
LMO1GATA31088959020185 9819382 Affinity Capture-Western; Reconstituted Complex
LMO1GATA31101909020185 9819382 Affinity Capture-Western; Reconstituted Complex
LMO2GATA31101919819382 Affinity Capture-Western
LMO2GATA31088959819382 Affinity Capture-Western
TAL1GATA31127499819382 Affinity Capture-Western
TAL1GATA31088959819382 Affinity Capture-Western
MDM2GATA310889515975924 Affinity Capture-Western
MDM2GATA311035815975924 Affinity Capture-Western
UBCGATA310889515975924 Affinity Capture-Western
UBCGATA311316415975924 Affinity Capture-Western
HDAC4GATA311510616922677 Affinity Capture-Western
HDAC4GATA310889516922677 Affinity Capture-Western
HDAC5GATA310889517075044 Affinity Capture-Western
HDAC5GATA311533117075044 Affinity Capture-Western
TBX21GATA310889517075044 Affinity Capture-Western
TBX21GATA311902717075044 Affinity Capture-Western
HDAC3GATA310889517075044 Affinity Capture-Western
HDAC3GATA311436817075044 Affinity Capture-Western
SP1GATA310889518338249 Affinity Capture-Western; Reconstituted Complex
SP1GATA311255018338249 Affinity Capture-Western; Reconstituted Complex
REPIN1GATA310889518338249 Reconstituted Complex
REPIN1GATA311892718338249 Reconstituted Complex
RARBGATA310889520211142 Two-hybrid
RARBGATA311185020211142 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:95663
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-990415-82'