AutismKB 2.0

Annotation Details for GATA4


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Basic Information Top
Gene Symbol:GATA4 ( MGC126629 )
Gene Full Name: GATA binding protein 4
Band: 8p23.1
Quick LinksEntrez ID:2626; OMIM: 600576; Uniprot ID:GATA4_HUMAN; ENSEMBL ID: ENSG00000136574; HGNC ID: 4173
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus9566909
GO:0005634ISS-nucleus-
GO:0005634NAS-nucleus12845333
GO:0005654TAS-nucleoplasm-
GO:0016604IDA-nuclear body-
GO:0090575IDA-RNA polymerase II transcription factor complex9312027
GO ID Evidence Qualifier GO_term References
GO:0000977IBA-RNA polymerase II regulatory region sequence-specific DNA binding-
GO:0001076IDA-transcription factor activity, RNA polymerase II transcription factor binding21330551
GO:0001085IBA-RNA polymerase II transcription factor binding-
GO:0001158IEA-enhancer sequence-specific DNA binding-
GO:0001228IBA-transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding-
GO:0003677IDA-DNA binding24000169
GO:0003677ISS-DNA binding-
GO:0003682IBA-chromatin binding-
GO:0003700IDAcontributes_totranscription factor activity, sequence-specific DNA binding9312027
GO:0003713IDA-transcription coactivator activity21220346
GO:0005515IPI-protein binding9312027
GO:0008134IPI-transcription factor binding9858576
GO:0008270IEA-zinc ion binding-
GO:0019901IEA-protein kinase binding-
GO:0033613ISS-activating transcription factor binding-
GO:0043565ISS-sequence-specific DNA binding-
GO:0044212IDA-transcription regulatory region DNA binding9566909
GO:0051525IEA-NFAT protein binding-
GO:0070410IPI-co-SMAD binding21330551
GO ID Evidence Qualifier GO_term References
GO:0001947ISS-heart looping-
GO:0003197IMP-endocardial cushion development21330551
GO:0003197ISS-endocardial cushion development-
GO:0003208TAS-cardiac ventricle morphogenesis20347099
GO:0003215ISS-cardiac right ventricle morphogenesis-
GO:0003281ISS-ventricular septum development-
GO:0003289ISS-atrial septum primum morphogenesis-
GO:0003290IMP-atrial septum secundum morphogenesis20347099
GO:0006355ISS-regulation of transcription, DNA-templated-
GO:0006366ISS-transcription from RNA polymerase II promoter12845333
GO:0007267ISS-cell-cell signaling-
GO:0007492TAS-endoderm development20347099
GO:0007596TAS-blood coagulation-
GO:0008584IEP-male gonad development17848411
GO:0008584IMP-male gonad development21220346
GO:0009612IEA-response to mechanical stimulus-
GO:0010507IEA-negative regulation of autophagy-
GO:0010575ISS-positive regulation of vascular endothelial growth factor production-
GO:0030513IEA-positive regulation of BMP signaling pathway-
GO:0033189IEA-response to vitamin A-
GO:0035054ISS-embryonic heart tube anterior/posterior pattern specification-
GO:0042493IMP-response to drug20585342
GO:0045766ISS-positive regulation of angiogenesis-
GO:0045893IDA-positive regulation of transcription, DNA-templated24000169
GO:0045893ISS-positive regulation of transcription, DNA-templated-
GO:0045944IDA-positive regulation of transcription from RNA polymerase II promoter21330551
GO:0045944ISS-positive regulation of transcription from RNA polymerase II promoter-
GO:0048617ISS-embryonic foregut morphogenesis-
GO:0051891ISS-positive regulation of cardioblast differentiation-
GO:0060290IEA-transdifferentiation-
GO:0060413IMP-atrial septum morphogenesis12845333
GO:0060575IDA-intestinal epithelial cell differentiation9566909
GO:0061049IEA-cell growth involved in cardiac muscle cell development-
GO:0071333IEA-cellular response to glucose stimulus-
GO:0086004IEA-regulation of cardiac muscle cell contraction-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
GATA4NKX2-51088969312027 10948187 12845333 Affinity Capture-Western; Reconstituted Complex
GATA4NKX2-51078649312027 10948187 12845333 Affinity Capture-Western; Reconstituted Complex
GATA4EP30010834718252717 Affinity Capture-Western
GATA4EP30010889618252717 Affinity Capture-Western
GATA4NR5A110889610446911 Reconstituted Complex
GATA4NR5A110879210446911 Reconstituted Complex
ZFPM2GATA41088969927675 18252717 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
ZFPM2GATA41169869927675 18252717 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SRFGATA411260011003651 11158291 Affinity Capture-Western; Reconstituted Complex
SRFGATA410889611003651 11158291 Affinity Capture-Western; Reconstituted Complex
MAPK1GATA410889611585926 Biochemical Activity
MAPK1GATA411158011585926 Biochemical Activity
HAND2GATA411485011994297 Affinity Capture-Western; Reconstituted Complex
HAND2GATA410889611994297 Affinity Capture-Western; Reconstituted Complex
TBX5GATA411277312845333 Affinity Capture-Western
TBX5GATA410889612845333 Affinity Capture-Western
MDC1GATA411501414578343 Protein-peptide
MDC1GATA410889614578343 Protein-peptide
SP1GATA410889614988427 Affinity Capture-Western; Reconstituted Complex
SP1GATA411255014988427 Affinity Capture-Western; Reconstituted Complex
ID1GATA410889616556596 Affinity Capture-Western; Reconstituted Complex
ID1GATA410962316556596 Affinity Capture-Western; Reconstituted Complex
ID2GATA410889616556596 Affinity Capture-Western; Reconstituted Complex
ID2GATA410962416556596 Affinity Capture-Western; Reconstituted Complex
ID3GATA410889616556596 Affinity Capture-Western; Reconstituted Complex
ID3GATA410962516556596 Affinity Capture-Western; Reconstituted Complex
ALX4GATA412193820211142 Two-hybrid
ALX4GATA410889620211142 Two-hybrid
ZBTB3GATA412293320211142 Two-hybrid
ZBTB3GATA410889620211142 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:95664
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-980526-476'