AutismKB 2.0

Annotation Details for FBXO4


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Basic Information Top
Gene Symbol:FBXO4 ( DKFZp547N213,FBX4,FLJ10141 )
Gene Full Name: F-box protein 4
Band: 5p13.1
Quick LinksEntrez ID:26272; OMIM: 609090; Uniprot ID:FBX4_HUMAN; ENSEMBL ID: ENSG00000151876; HGNC ID: 13583
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000151IDA-ubiquitin ligase complex10531035
GO:0005737IDA-cytoplasm21378169
GO:0005829TAS-cytosol-
GO:0019005IDA-SCF ubiquitin ligase complex20181953
GO ID Evidence Qualifier GO_term References
GO:0004842EXP-ubiquitin-protein transferase activity19028597
GO:0004842IDA-ubiquitin-protein transferase activity10531035
GO:0004842TAS-ubiquitin-protein transferase activity-
GO:0005515IPI-protein binding16278047
GO:0042803IPI-protein homodimerization activity20181953
GO:0061630IEA-ubiquitin protein ligase activity-
GO ID Evidence Qualifier GO_term References
GO:0000209IDA-protein polyubiquitination20181953
GO:0000209TAS-protein polyubiquitination-
GO:0007568IEA-aging-
GO:0010608IEA-posttranscriptional regulation of gene expression-
GO:0016567IDA-protein ubiquitination10531035
GO:0016567TAS-protein ubiquitination24389012
GO:0019725IEA-cellular homeostasis-
GO:0031146IDA-SCF-dependent proteasomal ubiquitin-dependent protein catabolic process20159592
GO:0031398IDA-positive regulation of protein ubiquitination24389012
GO:0031647IDA-regulation of protein stability24389012
GO:0031647IMP-regulation of protein stability16275645
GO:0031648IEA-protein destabilization-
GO:0032212IC-positive regulation of telomere maintenance via telomerase24389012
GO:0032212IMP-positive regulation of telomere maintenance via telomerase16275645
GO:0035726IEA-common myeloid progenitor cell proliferation-
GO:0043687TAS-post-translational protein modification-
GO:0048147IEA-negative regulation of fibroblast proliferation-
GO:0071479IEA-cellular response to ionizing radiation-
GO:1900181IEA-negative regulation of protein localization to nucleus-
GO:1902916IEA-positive regulation of protein polyubiquitination-
GO:2000001IEA-regulation of DNA damage checkpoint-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
FBXO4CDC3411765610531035 Biochemical Activity
FBXO4CDC3410743210531035 Biochemical Activity
FBXO4NEDD811765617353931 Affinity Capture-MS
FBXO4NEDD811081517353931 Affinity Capture-MS
FBXO4SKP111765610531035 17353931 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
FBXO4SKP111239110531035 17353931 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
FBXO4TERF111765616275645 Affinity Capture-Western; Reconstituted Complex
FBXO4TERF111287216275645 Affinity Capture-Western; Reconstituted Complex
FBXO4UBE2D211765610531035 Biochemical Activity
FBXO4UBE2D211317010531035 Biochemical Activity
FBXO4CUL111403210531035 17353931 Affinity Capture-MS; Affinity Capture-Western
FBXO4CUL111765610531035 17353931 Affinity Capture-MS; Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:2146220
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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