AutismKB 2.0

Annotation Details for GBP1


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Basic Information Top
Gene Symbol:GBP1 ( - )
Gene Full Name: guanylate binding protein 1, interferon-inducible, 67kDa
Band: 1p22.2
Quick LinksEntrez ID:2633; OMIM: 600411; Uniprot ID:GBP1_HUMAN; ENSEMBL ID: ENSG00000117228; HGNC ID: 4182
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000139IEA-Golgi membrane-
GO:0005576IEA-extracellular region-
GO:0005829IDA-cytosol24337748
GO:0005829TAS-cytosol-
GO:0005886IEA-plasma membrane-
GO ID Evidence Qualifier GO_term References
GO:0003779IDA-actin binding24337748
GO:0003924IDA-GTPase activity10676968
GO:0005515IPI-protein binding24337748
GO:0005525IDA-GTP binding10676968
GO:0019003IDA-GDP binding10676968
GO:0019899IPI-enzyme binding24337748
GO:0019955IPI-cytokine binding24337748
GO:0030507IPI-spectrin binding24337748
GO:0042802IPI-identical protein binding22059445
GO:0042803IDA-protein homodimerization activity10676968
GO:0051879IPI-Hsp90 protein binding24337748
GO ID Evidence Qualifier GO_term References
GO:0050848IMP-regulation of calcium-mediated signaling24337748
GO:0050860IMP-negative regulation of T cell receptor signaling pathway24337748
GO:0051260IDA-protein homooligomerization10676968
GO:0051607IEA-defense response to virus-
GO:0060333TAS-interferon-gamma-mediated signaling pathway-
GO:0070373IMP-negative regulation of ERK1 and ERK2 cascade24337748
GO:1900025IMP-negative regulation of substrate adhesion-dependent cell spreading24337748
GO:1900041IMP-negative regulation of interleukin-2 secretion24337748
GO:1903076IGI-regulation of protein localization to plasma membrane24337748
GO:1903077IMP-negative regulation of protein localization to plasma membrane24337748
Protein-Protein Interaction Top
AlzGene, PDGene and SZGene Top
Animal Model Top
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018