AutismKB 2.0

Annotation Details for USP21


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Basic Information Top
Gene Symbol:USP21 ( MGC3394,USP16,USP23 )
Gene Full Name: ubiquitin specific peptidase 21
Band: 1q23.3
Quick LinksEntrez ID:27005; OMIM: 604729; Uniprot ID:UBP21_HUMAN; ENSEMBL ID: ENSG00000143258; HGNC ID: 12620
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005575ND-cellular_component-
GO:0005654IDA-nucleoplasm-
GO:0005654TAS-nucleoplasm-
GO:0005829IDA-cytosol-
GO:0005829TAS-cytosol-
GO:0005886IDA-plasma membrane-
GO ID Evidence Qualifier GO_term References
GO:0003713ISS-transcription coactivator activity-
GO:0004843IDA-thiol-dependent ubiquitin-specific protease activity10799498
GO:0004843IMP-thiol-dependent ubiquitin-specific protease activity26100909
GO:0005515IPI-protein binding25416956
GO:0008234IMP-cysteine-type peptidase activity10799498
GO:0008234ISS-cysteine-type peptidase activity-
GO:0019784IDA-NEDD8-specific protease activity10799498
GO:0036459IDA-thiol-dependent ubiquitinyl hydrolase activity10799498
GO:0036459ISS-thiol-dependent ubiquitinyl hydrolase activity-
GO:0036459TAS-thiol-dependent ubiquitinyl hydrolase activity10786635
GO:0046872IEA-metal ion binding-
GO ID Evidence Qualifier GO_term References
GO:0006351IEA-transcription, DNA-templated-
GO:0006511IEA-ubiquitin-dependent protein catabolic process-
GO:0016578ISS-histone deubiquitination-
GO:0016579TAS-protein deubiquitination-
GO:0031175IEA-neuron projection development-
GO:0045893ISS-positive regulation of transcription, DNA-templated-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
USP21MARK211795019615732 Affinity Capture-MS
USP21MARK210832619615732 Affinity Capture-MS
USP21FUCA110879319615732 Affinity Capture-MS
USP21FUCA111795019615732 Affinity Capture-MS
USP21MARK111030919615732 Affinity Capture-MS
USP21MARK111795019615732 Affinity Capture-MS
USP21MARK311795019615732 Affinity Capture-MS
USP21MARK311031019615732 Affinity Capture-MS
USP21PPIB11795019615732 Affinity Capture-MS
USP21PPIB11147519615732 Affinity Capture-MS
USP21PRKCI11795019615732 Affinity Capture-MS
USP21PRKCI11157019615732 Affinity Capture-MS
USP21UCHL111319219615732 Affinity Capture-MS
USP21UCHL111795019615732 Affinity Capture-MS
USP21UTRN11795019615732 Affinity Capture-MS
USP21UTRN11324519615732 Affinity Capture-MS
USP21RIPK111427419910467 Affinity Capture-Western
USP21RIPK111795019910467 Affinity Capture-Western
USP21RBM8A11526519615732 Affinity Capture-MS
USP21RBM8A11795019615732 Affinity Capture-MS
USP21USP2011607719615732 Affinity Capture-MS
USP21USP2011795019615732 Affinity Capture-MS
USP21ANKRD2811684719615732 Affinity Capture-MS
USP21ANKRD2811795019615732 Affinity Capture-MS
RBM45USP2112621019615732 Affinity Capture-MS
RBM45USP2111795019615732 Affinity Capture-MS
PPP6R3USP2112057919615732 Affinity Capture-MS
PPP6R3USP2111795019615732 Affinity Capture-MS
BEND3USP2112170419615732 Affinity Capture-MS
BEND3USP2111795019615732 Affinity Capture-MS
MARK4USP2112176019615732 Affinity Capture-MS
MARK4USP2111795019615732 Affinity Capture-MS
UPF3BUSP2112239619615732 Affinity Capture-MS
UPF3BUSP2111795019615732 Affinity Capture-MS
USP48USP2112394119615732 Affinity Capture-MS
USP48USP2111795019615732 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1353665
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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