AutismKB 2.0

Annotation Details for LAT


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Basic Information Top
Gene Symbol:LAT ( LAT1,pp36 )
Gene Full Name: linker for activation of T cells
Band: 16q13
Quick LinksEntrez ID:27040; OMIM: 602354; Uniprot ID:LAT_HUMAN; ENSEMBL ID: ENSG00000213658; HGNC ID: 18874
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0001772IDA-immunological synapse12646565
GO:0005886TAS-plasma membrane-
GO:0005911IEA-cell-cell junction-
GO:0008180ISS-COP9 signalosome-
GO:0016021IDA-integral component of membrane12646565
GO:0042629IEA-mast cell granule-
GO:0045121TAS-membrane raft14722116
GO ID Evidence Qualifier GO_term References
GO:0005070IDA-SH3/SH2 adaptor activity9489702
GO:0005088TAS-Ras guanyl-nucleotide exchange factor activity-
GO:0005515IPI-protein binding9489702
GO:0019901IPI-protein kinase binding12186560
GO ID Evidence Qualifier GO_term References
GO:0000165TAS-MAPK cascade-
GO:0002250IEA-adaptive immune response-
GO:0002260IEA-lymphocyte homeostasis-
GO:0006954IEA-inflammatory response-
GO:0006955IDA-immune response15100278
GO:0007229IDA-integrin-mediated signaling pathway15100278
GO:0007265IMP-Ras protein signal transduction12646565
GO:0009967IEA-positive regulation of signal transduction-
GO:0010467IEA-gene expression-
GO:0019722IMP-calcium-mediated signaling12646565
GO:0030168TAS-platelet activation-
GO:0035556IDA-intracellular signal transduction12646565
GO:0038095TAS-Fc-epsilon receptor signaling pathway-
GO:0042110TAS-T cell activation12186560
GO:0043303IEA-mast cell degranulation-
GO:0043547IEA-positive regulation of GTPase activity-
GO:0045860IEP-positive regulation of protein kinase activity14624253
GO:0050852TAS-T cell receptor signaling pathway-
GO:0050863IMP-regulation of T cell activation12646565
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
LATFCGR1A11797110781611 Affinity Capture-Western
LATFCGR1A10850310781611 Affinity Capture-Western
LATFCGR2A11797110781611 Affinity Capture-Western
LATFCGR2A10850610781611 Affinity Capture-Western
LATGRB21179719489702 11368773 12186560 Affinity Capture-Western; Reconstituted Complex
LATGRB21091429489702 11368773 12186560 Affinity Capture-Western; Reconstituted Complex
LATITK11797110506192 12186560 Affinity Capture-Western; Biochemical Activity
LATITK10990710506192 12186560 Affinity Capture-Western; Biochemical Activity
LATPIK3R111797111368773 Affinity Capture-Western; Reconstituted Complex
LATPIK3R111131311368773 Affinity Capture-Western; Reconstituted Complex
LATPLCG11179719489702 9729044 11368773 Affinity Capture-Western; Co-fractionation; Reconstituted Complex
LATPLCG11113519489702 9729044 11368773 Affinity Capture-Western; Co-fractionation; Reconstituted Complex
LATPTPRJ11797111259588 Biochemical Activity
LATPTPRJ11175911259588 Biochemical Activity
LATSH3BP21179719846481 11390470 Affinity Capture-Western; Reconstituted Complex
LATSH3BP21123509846481 11390470 Affinity Capture-Western; Reconstituted Complex
LATSHB11235810488157 12084069 Affinity Capture-Western
LATSHB11797110488157 12084069 Affinity Capture-Western
LATSLA11797110449770 Affinity Capture-Western
LATSLA11239410449770 Affinity Capture-Western
LATSYK11797111368773 Biochemical Activity
LATSYK11271711368773 Biochemical Activity
LATUBC11797117938199 Affinity Capture-Western
LATUBC11316417938199 Affinity Capture-Western
LATVAV111797111368773 12186560 Affinity Capture-Western; Reconstituted Complex
LATVAV111325211368773 12186560 Affinity Capture-Western; Reconstituted Complex
LATZAP7011336711368773 12186560 Biochemical Activity
LATZAP7011797111368773 12186560 Biochemical Activity
LATGRAP211479910021361 10224278 Affinity Capture-Western; Reconstituted Complex
LATGRAP211797110021361 10224278 Affinity Capture-Western; Reconstituted Complex
LATGAB211518111572860 Affinity Capture-Western
LATGAB211797111572860 Affinity Capture-Western
LATGRAP1159739489702 12186560 Affinity Capture-Western; Reconstituted Complex
LATGRAP1179719489702 12186560 Affinity Capture-Western; Reconstituted Complex
LATUSP1911607819615732 Affinity Capture-MS
LATUSP1911797119615732 Affinity Capture-MS
LATMAP4K111635411279207 Affinity Capture-Western; Co-fractionation
LATMAP4K111797111279207 Affinity Capture-Western; Co-fractionation
CLYBLLAT12812611368773 Affinity Capture-Western
CLYBLLAT11797111368773 Affinity Capture-Western
Gene Symbol Interactant Interaction ID References Description
LATPLCG121652515696170 LAT interacts with an unspecified isoform of PLC-gamma-1.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1342293
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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