AutismKB 2.0

Annotation Details for DISC1


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Basic Information Top
Gene Symbol:DISC1 ( C1orf136,FLJ13381,FLJ21640,FLJ25311,FLJ41105,KIAA0457,SCZD9 )
Gene Full Name: disrupted in schizophrenia 1
Band: 1q42.2
Quick LinksEntrez ID:27185; OMIM: 605210; Uniprot ID:DISC1_HUMAN; ENSEMBL ID: ENSG00000162946; HGNC ID: 2888
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IEA-nucleus-
GO:0005739IDA-mitochondrion20880836
GO:0005783IEA-endoplasmic reticulum-
GO:0005813IDA-centrosome18762586
GO:0005829IEA-cytosol-
GO:0005871IEA-kinesin complex-
GO:0005874IEA-microtubule-
GO:0008021IEA-synaptic vesicle-
GO:0014069IEA-postsynaptic density-
GO:0030054IEA-cell junction-
GO:0030286IEA-dynein complex-
GO:0030424IEA-axon-
GO:0036064IEA-ciliary basal body-
GO:0044297IEA-cell body-
GO:0045211IEA-postsynaptic membrane-
GO:0048471IEA-perinuclear region of cytoplasm-
GO:0090724IEA-central region of growth cone-
GO:0097546IDA-ciliary base20531939
GO ID Evidence Qualifier GO_term References
GO:0005515IPI-protein binding12812986
GO:0019894IEA-kinesin binding-
GO:0032403IEA-protein complex binding-
GO:0032947IEA-protein complex scaffold-
GO ID Evidence Qualifier GO_term References
GO:0000226IMP-microtubule cytoskeleton organization18955030
GO:0001764IMP-neuron migration19502360
GO:0001954IEA-positive regulation of cell-matrix adhesion-
GO:0002052IGI-positive regulation of neuroblast proliferation19303846
GO:0021846IEA-cell proliferation in forebrain-
GO:0021852IEA-pyramidal neuron migration-
GO:0030177IGI-positive regulation of Wnt signaling pathway19303846
GO:0031929IEA-TOR signaling-
GO:0045773IEA-positive regulation of axon extension-
GO:0051560IEA-mitochondrial calcium ion homeostasis-
GO:0051602IEA-response to electrical stimulus-
GO:0051966IEA-regulation of synaptic transmission, glutamatergic-
GO:0060070IEA-canonical Wnt signaling pathway-
GO:0060998IEA-regulation of dendritic spine development-
GO:0071539IEA-protein localization to centrosome-
GO:0090128IEA-regulation of synapse maturation-
GO:1905515IMP-non-motile cilium assembly20531939
GO:2000060IEA-positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
DISC1ACTN211806112812986 Affinity Capture-Western; Two-hybrid
DISC1ACTN210660312812986 Affinity Capture-Western; Two-hybrid
DISC1ATF410695812812986 Two-hybrid
DISC1ATF411806112812986 Two-hybrid
DISC1COL4A110767912812986 Two-hybrid
DISC1COL4A111806112812986 Two-hybrid
DISC1MAP1A11030312812986 Affinity Capture-Western; Two-hybrid
DISC1MAP1A11806112812986 Affinity Capture-Western; Two-hybrid
DISC1MYO1A11806112812986 Two-hybrid
DISC1MYO1A11072412812986 Two-hybrid
DISC1ITSN111806112812986 Two-hybrid
DISC1ITSN111235112812986 Two-hybrid
DISC1YWHAG11806112506198 Two-hybrid
DISC1YWHAG11336412506198 Two-hybrid
DISC1RASSF711806112812986 Two-hybrid
DISC1RASSF711373512812986 Two-hybrid
DISC1EIF3A11421012812986 Affinity Capture-Western; Two-hybrid
DISC1EIF3A11806112812986 Affinity Capture-Western; Two-hybrid
DISC1EIF3H11421612812986 Two-hybrid
DISC1EIF3H11806112812986 Two-hybrid
DISC1FEZ111806112874605 Affinity Capture-Western; Two-hybrid
DISC1FEZ111499712874605 Affinity Capture-Western; Two-hybrid
DISC1RANBP911806112812986 Affinity Capture-Western; Two-hybrid
DISC1RANBP911535912812986 Affinity Capture-Western; Two-hybrid
DISC1CIT11806112506198 Two-hybrid
DISC1CIT11629012506198 Two-hybrid
DISC1ATF511648712812986 Affinity Capture-Western; Two-hybrid
DISC1ATF511806112812986 Affinity Capture-Western; Two-hybrid
DISC1SYNE111692812812986 Affinity Capture-Western; Two-hybrid
DISC1SYNE111806112812986 Affinity Capture-Western; Two-hybrid
DISC1TRAF3IP111806112812986 Affinity Capture-Western; Two-hybrid
DISC1TRAF3IP111757712812986 Affinity Capture-Western; Two-hybrid
NDEL1DISC111806112506198 12812986 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NDEL1DISC112352712506198 12812986 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
KCNQ5DISC111806112506198 Two-hybrid
KCNQ5DISC112114912506198 Two-hybrid
SPTBN4DISC111806112812986 Affinity Capture-Western; Two-hybrid
SPTBN4DISC112175112812986 Affinity Capture-Western; Two-hybrid
CEP63DISC111806112812986 Affinity Capture-Western; Two-hybrid
CEP63DISC112320012812986 Affinity Capture-Western; Two-hybrid
CCDC141DISC113000012812986 Two-hybrid
CCDC141DISC111806112812986 Two-hybrid
ATF7IPDISC111806112812986 Two-hybrid
ATF7IPDISC112084912812986 Two-hybrid
KIAA1377DISC112161712812986 Two-hybrid
KIAA1377DISC111806112812986 Two-hybrid
Gene Symbol Interactant Interaction ID References Description
DISC1ACTN220909812812986 DISC-1 interacts with alpha-actinin 2.
DISC1PPFIA425963214623284 An unspecified isoform of DISC1 interacts with PPFIA4.
DISC1RANBP920910212812986 DISC-1 interacts with RanBPM.
DISC1TRAF3IP120946812812986 DISC-1 interacts with MIP-T3.
NDE1DISC125963714623284 An unspecified isoform of DISC1 interacts with NUDE.
CEP290DISC125963414623284 An unspecified isoform of DISC1 interacts with KIAA0373.
KATNAL1DISC125962714623284 An unspecified isoform of DISC1 interacts with MGC2599.
No data
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
DISC1AT157017, CA212755, CA95066, D1S1621, DISC1_-94A/C, DISC1_1393C>T, DISC1_1407C>T, DISC1_1863G>A, DISC1_2bpSTR, DISC1_G65049, DISC1_IVS7+6C>T, hCV9627536, rs1000730, rs1000731, rs1015100, rs1015101, rs10158776, rs1030711, rs10495310, rs1073179, rs1073180, rs10746510, rs1079344, rs10864695, rs10864702, rs1094658, rs11122330, rs11122331, rs11122343, rs11122347, rs11122348, rs11122355, rs11122359, rs11122362, rs11122366, rs11122374, rs11122381, rs11122396, rs11576588, rs11577215, rs11585831, rs11585981, rs11590192, rs1160491, rs12027635, rs12029621, rs12032135, rs12046794, rs12060283, rs12084975, rs12087793, rs12088230, rs12090070, rs12135059, rs12137417, rs12139117, rs12139880, rs12143549, rs12404162, rs12731570, rs12744978, rs12751370, rs12754402, rs12754734, rs1285730, rs1322783, rs1322784, rs1322786, rs1331056, rs1340982, rs1341553, rs1407598, rs1411771, rs1411775, rs1411776, rs1417584, rs1417585, rs1417865, rs1417866, rs1535529, rs1538975, rs1538976, rs1538977, rs1538978, rs1538979, rs1572899, rs1655296, rs16841582, rs16854723, rs16854903, rs16854954, rs16854957, rs16855096, rs16855854, rs16855921, rs16856154, rs16856182, rs16856189, rs16856275, rs16856322, rs1772686, rs17746859, rs17748992, rs17749164, rs17766087, rs17768115, rs17770256, rs17770286, rs17773715, rs17804007, rs17804163, rs17816686, rs17817356, rs17817463, rs17820909, rs17825699, rs1865225, rs1865226, rs1895225, rs1934909, rs1954175, rs1977797, rs1984895, rs1998406, rs2038636, rs2082552, rs2255340, rs2273890, rs2295959, rs2356710, rs2487453, rs2492367, rs2738864, rs2738875, rs2738877, rs2738880, rs2738887, rs2759329, rs2759330, rs2759339, rs2759340, rs2759345, rs2759346, rs2759352, rs2772122, rs2776623, rs2793085, rs2793091, rs2793092, rs2793094, rs2793101, rs2794273, rs2806465, rs2807578, rs2812379, rs2812385, rs2812388, rs2812389, rs2812391, rs2812393, rs2812395, rs3054533, rs3082, rs3524, rs3737597, rs3738398, rs3738399, rs3738400, rs3738401, rs3738402, rs3806372, rs4325116, rs4366301, rs4658879, rs4658882, rs4658890, rs4658894, rs4658933, rs4658945, rs4658949, rs4658954, rs4658963, rs4658966, rs4658970, rs4658971, rs6541280, rs6541281, rs6663190, rs6667141, rs6668845, rs6672782, rs6674099, rs6675281, rs6677638, rs6678723, rs6679985, rs6687236, rs6691979, rs6695394, rs6700577, rs701158, rs701160, rs701161, rs701163, rs734551, rs748583, rs751229, rs7529706, rs7533169, rs7534681, rs7541019, rs7546310, rs7548491, rs7551537, rs821577, rs821581, rs821592, rs821597, rs821600, rs821616, rs821631, rs821633, rs821639, rs821645, rs821647, rs821653, rs821663, rs821664, rs821717, rs821723, rs823161, rs823162, rs823163, rs823165, rs823167, rs843979, rs860275, rs892356, rs928099, rs928100, rs9308481, rs9308482, rs9431711, rs9431714, rs9431730, rs9431736, rs9431997, rs9432010, rs9432017, rs9432024, rs9432025, rs9432061, rs9659663, rs967244, rs967433, rs967434, rs9726024, rs9727641, rs9729179, rs9803690, rs980394, rs980989, rs999708, rs999709, rs999710 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:2447658
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-090122-1'