AutismKB 2.0

Annotation Details for RABGEF1


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Basic Information Top
Gene Symbol:RABGEF1 ( FLJ32302,RABEX5,rabex-5 )
Gene Full Name: RAB guanine nucleotide exchange factor (GEF) 1
Band: 7q11.21
Quick LinksEntrez ID:27342; OMIM: 609700; Uniprot ID:RABX5_HUMAN; ENSEMBL ID: ENSG00000154710,ENSG00000243335; HGNC ID: 17676
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005730IDA-nucleolus-
GO:0005769IMP-early endosome23382462
GO:0005829IDA-cytosol-
GO:0005829TAS-cytosol-
GO:0031901TAS-early endosome membrane-
GO:0055037IEA-recycling endosome-
GO ID Evidence Qualifier GO_term References
GO:0003677IEA-DNA binding-
GO:0005515IPI-protein binding16189514
GO:0008270IEA-zinc ion binding-
GO:0017112IDA-Rab guanyl-nucleotide exchange factor activity20937701
GO:0017112IMP-Rab guanyl-nucleotide exchange factor activity23382462
GO:0017112TAS-Rab guanyl-nucleotide exchange factor activity-
GO:0017137IPI-Rab GTPase binding23382462
GO:0061630IEA-ubiquitin protein ligase activity-
GO ID Evidence Qualifier GO_term References
GO:0001933IEA-negative regulation of protein phosphorylation-
GO:0002686IEA-negative regulation of leukocyte migration-
GO:0006612IMP-protein targeting to membrane23382462
GO:0006897IEA-endocytosis-
GO:0016567IEA-protein ubiquitination-
GO:0043305IEA-negative regulation of mast cell degranulation-
GO:0043547IEA-positive regulation of GTPase activity-
GO:0046580IEA-negative regulation of Ras protein signal transduction-
GO:0048261IEA-negative regulation of receptor-mediated endocytosis-
GO:0050728IEA-negative regulation of inflammatory response-
GO:0060368IEA-regulation of Fc receptor mediated stimulatory signaling pathway-
GO:0061024TAS-membrane organization-
GO:1900165IEA-negative regulation of interleukin-6 secretion-
GO:1900235IEA-negative regulation of Kit signaling pathway-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
RABGEF1UBC11316416407276 Affinity Capture-Western
RABGEF1UBC11815416407276 Affinity Capture-Western
RABGEF1YWHAB11336117353931 Affinity Capture-MS
RABGEF1YWHAB11815417353931 Affinity Capture-MS
RABGEF1YWHAG11815417353931 Affinity Capture-MS
RABGEF1YWHAG11336417353931 Affinity Capture-MS
RABGEF1GGA111754012505986 Reconstituted Complex
RABGEF1GGA111815412505986 Reconstituted Complex
C19orf50RABGEF112250116189514 Affinity Capture-Western; Two-hybrid
C19orf50RABGEF111815416189514 Affinity Capture-Western; Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1929459
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040426-1486'