Gene Symbol:	GLI2 ( HPE9,THP1,THP2 )
Gene Full Name:	GLI family zinc finger 2
Band:	2q14.2
Quick Links	Entrez ID:2736; OMIM: 165230; Uniprot ID:GLI2_HUMAN; ENSEMBL ID: ENSG00000074047; HGNC ID: 4318
Relate to Another Database:	SFARIGene; denovo-db

GO ID	Evidence	Qualifier	GO_term	References
GO:0005634	IDA	-	nucleus	26565916
GO:0005654	TAS	-	nucleoplasm	-
GO:0005730	IDA	-	nucleolus	-
GO:0005829	TAS	-	cytosol	-
GO:0005929	ISS	-	cilium	-
GO:0005930	IEA	-	axoneme	-
GO:0016020	IEA	-	membrane	-
GO:0016607	IEA	-	nuclear speck	-
GO:0031514	IEA	-	motile cilium	-
GO:0097542	TAS	-	ciliary tip	-
GO:0097546	TAS	-	ciliary base	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0000978	IEA	-	RNA polymerase II core promoter proximal region sequence-specific DNA binding	-
GO:0001077	IEA	-	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding	-
GO:0003700	IDA	-	transcription factor activity, sequence-specific DNA binding	15994174
GO:0005515	IPI	-	protein binding	12435627
GO:0008134	IPI	-	transcription factor binding	26565916
GO:0008270	IDA	-	zinc ion binding	8378770
GO:0043565	IDA	-	sequence-specific DNA binding	9557682
GO:1990841	IDA	-	promoter-specific chromatin binding	26565916

GO ID	Evidence	Qualifier	GO_term	References
GO:0000122	IMP	-	negative regulation of transcription from RNA polymerase II promoter	15994174
GO:0001501	ISS	-	skeletal system development	-
GO:0001701	IEA	-	in utero embryonic development	-
GO:0001822	ISS	-	kidney development	-
GO:0002062	IEA	-	chondrocyte differentiation	-
GO:0002076	ISS	-	osteoblast development	-
GO:0006366	IEA	-	transcription from RNA polymerase II promoter	-
GO:0007224	IDA	-	smoothened signaling pathway	15994174
GO:0007389	ISS	-	pattern specification process	-
GO:0007411	ISS	-	axon guidance	-
GO:0007418	ISS	-	ventral midline development	-
GO:0007442	ISS	-	hindgut morphogenesis	-
GO:0007507	ISS	-	heart development	-
GO:0008283	IDA	-	cell proliferation	15994174
GO:0008589	IEA	-	regulation of smoothened signaling pathway	-
GO:0009612	IEA	-	response to mechanical stimulus	-
GO:0009952	IEA	-	anterior/posterior pattern specification	-
GO:0009954	ISS	-	proximal/distal pattern formation	-
GO:0021508	ISS	-	floor plate formation	-
GO:0021513	ISS	-	spinal cord dorsal/ventral patterning	-
GO:0021517	ISS	-	ventral spinal cord development	-
GO:0021696	ISS	-	cerebellar cortex morphogenesis	-
GO:0021775	ISS	-	smoothened signaling pathway involved in ventral spinal cord interneuron specification	-
GO:0021776	IEA	-	smoothened signaling pathway involved in spinal cord motor neuron cell fate specification	-
GO:0021938	IEA	-	smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation	-
GO:0021965	ISS	-	spinal cord ventral commissure morphogenesis	-
GO:0021983	ISS	-	pituitary gland development	-
GO:0030324	ISS	-	lung development	-
GO:0030879	ISS	-	mammary gland development	-
GO:0030902	ISS	-	hindbrain development	-
GO:0032331	IEA	-	negative regulation of chondrocyte differentiation	-
GO:0033089	ISS	-	positive regulation of T cell differentiation in thymus	-
GO:0035295	ISS	-	tube development	-
GO:0042475	ISS	-	odontogenesis of dentin-containing tooth	-
GO:0042733	IEA	-	embryonic digit morphogenesis	-
GO:0043066	IEA	-	negative regulation of apoptotic process	-
GO:0045666	IEA	-	positive regulation of neuron differentiation	-
GO:0045740	IDA	-	positive regulation of DNA replication	12165851
GO:0045893	IDA	-	positive regulation of transcription, DNA-templated	15175043
GO:0045944	IDA	-	positive regulation of transcription from RNA polymerase II promoter	12165851
GO:0048566	ISS	-	embryonic digestive tract development	-
GO:0048589	ISS	-	developmental growth	-
GO:0048666	ISS	-	neuron development	-
GO:0048754	ISS	-	branching morphogenesis of an epithelial tube	-
GO:0060032	IEA	-	notochord regression	-
GO:0060513	IEA	-	prostatic bud formation	-
GO:0060603	IEA	-	mammary gland duct morphogenesis	-
GO:0060831	IEA	-	smoothened signaling pathway involved in dorsal/ventral neural tube patterning	-
GO:0071407	IEA	-	cellular response to organic cyclic compound	-
GO:0090103	IEA	-	cochlea morphogenesis	-

Gene Symbol	Interactant	Interaction ID	References	Description
GLI2	CREB1	107775	10074179	Reconstituted Complex
GLI2	CREB1	108998	10074179	Reconstituted Complex
SUFU	GLI2	119676	10564661	Reconstituted Complex
SUFU	GLI2	108998	10564661	Reconstituted Complex
STK36	GLI2	118032	10806483	Affinity Capture-Western
STK36	GLI2	108998	10806483	Affinity Capture-Western
ZIC2	GLI2	113378	11238441	Affinity Capture-Western
ZIC2	GLI2	108998	11238441	Affinity Capture-Western
ZIC1	GLI2	113377	11238441	Affinity Capture-Western; Reconstituted Complex
ZIC1	GLI2	108998	11238441	Affinity Capture-Western; Reconstituted Complex
SKI	GLI2	108998	12435627	Reconstituted Complex; Two-hybrid
SKI	GLI2	112388	12435627	Reconstituted Complex; Two-hybrid
HDAC1	GLI2	109315	20081843	Affinity Capture-Western
HDAC1	GLI2	108998	20081843	Affinity Capture-Western

AutismKB 2.0

Annotation Details for GLI2