AutismKB 2.0

Annotation Details for GLI2


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Basic Information Top
Gene Symbol:GLI2 ( HPE9,THP1,THP2 )
Gene Full Name: GLI family zinc finger 2
Band: 2q14.2
Quick LinksEntrez ID:2736; OMIM: 165230; Uniprot ID:GLI2_HUMAN; ENSEMBL ID: ENSG00000074047; HGNC ID: 4318
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus26565916
GO:0005654TAS-nucleoplasm-
GO:0005730IDA-nucleolus-
GO:0005829TAS-cytosol-
GO:0005929ISS-cilium-
GO:0005930IEA-axoneme-
GO:0016020IEA-membrane-
GO:0016607IEA-nuclear speck-
GO:0031514IEA-motile cilium-
GO:0097542TAS-ciliary tip-
GO:0097546TAS-ciliary base-
GO ID Evidence Qualifier GO_term References
GO:0000978IEA-RNA polymerase II core promoter proximal region sequence-specific DNA binding-
GO:0001077IEA-transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding-
GO:0003700IDA-transcription factor activity, sequence-specific DNA binding15994174
GO:0005515IPI-protein binding12435627
GO:0008134IPI-transcription factor binding26565916
GO:0008270IDA-zinc ion binding8378770
GO:0043565IDA-sequence-specific DNA binding9557682
GO:1990841IDA-promoter-specific chromatin binding26565916
GO ID Evidence Qualifier GO_term References
GO:0000122IMP-negative regulation of transcription from RNA polymerase II promoter15994174
GO:0001501ISS-skeletal system development-
GO:0001701IEA-in utero embryonic development-
GO:0001822ISS-kidney development-
GO:0002062IEA-chondrocyte differentiation-
GO:0002076ISS-osteoblast development-
GO:0006366IEA-transcription from RNA polymerase II promoter-
GO:0007224IDA-smoothened signaling pathway15994174
GO:0007389ISS-pattern specification process-
GO:0007411ISS-axon guidance-
GO:0007418ISS-ventral midline development-
GO:0007442ISS-hindgut morphogenesis-
GO:0007507ISS-heart development-
GO:0008283IDA-cell proliferation15994174
GO:0008589IEA-regulation of smoothened signaling pathway-
GO:0009612IEA-response to mechanical stimulus-
GO:0009952IEA-anterior/posterior pattern specification-
GO:0009954ISS-proximal/distal pattern formation-
GO:0021508ISS-floor plate formation-
GO:0021513ISS-spinal cord dorsal/ventral patterning-
GO:0021517ISS-ventral spinal cord development-
GO:0021696ISS-cerebellar cortex morphogenesis-
GO:0021775ISS-smoothened signaling pathway involved in ventral spinal cord interneuron specification-
GO:0021776IEA-smoothened signaling pathway involved in spinal cord motor neuron cell fate specification-
GO:0021938IEA-smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation-
GO:0021965ISS-spinal cord ventral commissure morphogenesis-
GO:0021983ISS-pituitary gland development-
GO:0030324ISS-lung development-
GO:0030879ISS-mammary gland development-
GO:0030902ISS-hindbrain development-
GO:0032331IEA-negative regulation of chondrocyte differentiation-
GO:0033089ISS-positive regulation of T cell differentiation in thymus-
GO:0035295ISS-tube development-
GO:0042475ISS-odontogenesis of dentin-containing tooth-
GO:0042733IEA-embryonic digit morphogenesis-
GO:0043066IEA-negative regulation of apoptotic process-
GO:0045666IEA-positive regulation of neuron differentiation-
GO:0045740IDA-positive regulation of DNA replication12165851
GO:0045893IDA-positive regulation of transcription, DNA-templated15175043
GO:0045944IDA-positive regulation of transcription from RNA polymerase II promoter12165851
GO:0048566ISS-embryonic digestive tract development-
GO:0048589ISS-developmental growth-
GO:0048666ISS-neuron development-
GO:0048754ISS-branching morphogenesis of an epithelial tube-
GO:0060032IEA-notochord regression-
GO:0060513IEA-prostatic bud formation-
GO:0060603IEA-mammary gland duct morphogenesis-
GO:0060831IEA-smoothened signaling pathway involved in dorsal/ventral neural tube patterning-
GO:0071407IEA-cellular response to organic cyclic compound-
GO:0090103IEA-cochlea morphogenesis-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
GLI2CREB110777510074179 Reconstituted Complex
GLI2CREB110899810074179 Reconstituted Complex
SUFUGLI211967610564661 Reconstituted Complex
SUFUGLI210899810564661 Reconstituted Complex
STK36GLI211803210806483 Affinity Capture-Western
STK36GLI210899810806483 Affinity Capture-Western
ZIC2GLI211337811238441 Affinity Capture-Western
ZIC2GLI210899811238441 Affinity Capture-Western
ZIC1GLI211337711238441 Affinity Capture-Western; Reconstituted Complex
ZIC1GLI210899811238441 Affinity Capture-Western; Reconstituted Complex
SKIGLI210899812435627 Reconstituted Complex; Two-hybrid
SKIGLI211238812435627 Reconstituted Complex; Two-hybrid
HDAC1GLI210931520081843 Affinity Capture-Western
HDAC1GLI210899820081843 Affinity Capture-Western
Gene Symbol Interactant Interaction ID References Description
TBPGLI219744411160734 TBP interacts with GLI-2. This interaction was modeled on a demonstrated interaction between TBP from an unspecified species and human GLI-2.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:95728
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-050523-1'