AutismKB 2.0

Annotation Details for GLI3


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Basic Information Top
Gene Symbol:GLI3 ( ACLS,GCPS,PAP-A,PAPA,PAPA1,PAPB,PHS,PPDIV )
Gene Full Name: GLI family zinc finger 3
Band: 7p14.1
Quick LinksEntrez ID:2737; OMIM: 165240; Uniprot ID:GLI3_HUMAN; ENSEMBL ID: ENSG00000106571; HGNC ID: 4319
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus10693759
GO:0005654TAS-nucleoplasm-
GO:0005737IDA-cytoplasm10077605
GO:0005829IDA-cytosol18559511
GO:0005829TAS-cytosol-
GO:0005929IDA-cilium16254602
GO:0005930IEA-axoneme-
GO:0016592IDAcolocalizes_withmediator complex17000779
GO:0016607IEA-nuclear speck-
GO:0017053IEA-transcriptional repressor complex-
GO:0097542TAS-ciliary tip-
GO:0097546TAS-ciliary base-
GO ID Evidence Qualifier GO_term References
GO:0000977IDA-RNA polymerase II regulatory region sequence-specific DNA binding18298960
GO:0000978IDA-RNA polymerase II core promoter proximal region sequence-specific DNA binding2118997
GO:0001077IC-transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding-
GO:0003682IEA-chromatin binding-
GO:0003700IDA-transcription factor activity, sequence-specific DNA binding10077605
GO:0005515IPI-protein binding10564661
GO:0008013IPI-beta-catenin binding17331723
GO:0035035IPI-histone acetyltransferase binding10075717
GO:0042826IDA-histone deacetylase binding12435627
GO:0046872IEA-metal ion binding-
GO ID Evidence Qualifier GO_term References
GO:0000122IDA-negative regulation of transcription from RNA polymerase II promoter10693759
GO:0001656IEA-metanephros development-
GO:0001658IEA-branching involved in ureteric bud morphogenesis-
GO:0001701IEA-in utero embryonic development-
GO:0002052IEA-positive regulation of neuroblast proliferation-
GO:0006366IEA-transcription from RNA polymerase II promoter-
GO:0007224TAS-smoothened signaling pathway11001584
GO:0007411IEA-axon guidance-
GO:0007442IEA-hindgut morphogenesis-
GO:0007507IEA-heart development-
GO:0008285IEA-negative regulation of cell proliferation-
GO:0009952IEA-anterior/posterior pattern specification-
GO:0009954IEA-proximal/distal pattern formation-
GO:0016485IEA-protein processing-
GO:0021631IEA-optic nerve morphogenesis-
GO:0021766IEA-hippocampus development-
GO:0021775IEA-smoothened signaling pathway involved in ventral spinal cord interneuron specification-
GO:0021776IEA-smoothened signaling pathway involved in spinal cord motor neuron cell fate specification-
GO:0021798IEA-forebrain dorsal/ventral pattern formation-
GO:0021819IEA-layer formation in cerebral cortex-
GO:0021861IEA-forebrain radial glial cell differentiation-
GO:0022018IEA-lateral ganglionic eminence cell proliferation-
GO:0030318IEA-melanocyte differentiation-
GO:0030324IEA-lung development-
GO:0032332IEA-positive regulation of chondrocyte differentiation-
GO:0033077ISS-T cell differentiation in thymus-
GO:0035108IMP-limb morphogenesis9354785
GO:0042060IEA-wound healing-
GO:0042307IEA-positive regulation of protein import into nucleus-
GO:0042475IEA-odontogenesis of dentin-containing tooth-
GO:0042733TAS-embryonic digit morphogenesis11001584
GO:0043066IEA-negative regulation of apoptotic process-
GO:0043585TAS-nose morphogenesis11001584
GO:0043586IEA-tongue development-
GO:0043627IEA-response to estrogen-
GO:0045060ISS-negative thymic T cell selection-
GO:0045665IEA-negative regulation of neuron differentiation-
GO:0045669IEA-positive regulation of osteoblast differentiation-
GO:0045879ISS-negative regulation of smoothened signaling pathway-
GO:0045892IDA-negative regulation of transcription, DNA-templated12435627
GO:0045893ISS-positive regulation of transcription, DNA-templated-
GO:0045944IDA-positive regulation of transcription from RNA polymerase II promoter17000779
GO:0045944IMP-positive regulation of transcription from RNA polymerase II promoter18559511
GO:0046638ISS-positive regulation of alpha-beta T cell differentiation-
GO:0046639ISS-negative regulation of alpha-beta T cell differentiation-
GO:0048557IEA-embryonic digestive tract morphogenesis-
GO:0048566TAS-embryonic digestive tract development11001584
GO:0048589IEA-developmental growth-
GO:0048593IEA-camera-type eye morphogenesis-
GO:0048704IEA-embryonic skeletal system morphogenesis-
GO:0048709IEA-oligodendrocyte differentiation-
GO:0060021IEA-palate development-
GO:0060364IEA-frontal suture morphogenesis-
GO:0060366IEA-lambdoid suture morphogenesis-
GO:0060367IEA-sagittal suture morphogenesis-
GO:0060594IEA-mammary gland specification-
GO:0060831IEA-smoothened signaling pathway involved in dorsal/ventral neural tube patterning-
GO:0060840IEA-artery development-
GO:0060873IEA-anterior semicircular canal development-
GO:0060875IEA-lateral semicircular canal development-
GO:0061005IEA-cell differentiation involved in kidney development-
GO:0070242ISS-thymocyte apoptotic process-
GO:0090090IDA-negative regulation of canonical Wnt signaling pathway17331723
GO:1903010IEA-regulation of bone development-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
GLI3CREBBP10777710075717 17000779 Affinity Capture-Western; Reconstituted Complex
GLI3CREBBP10899910075717 17000779 Affinity Capture-Western; Reconstituted Complex
SUFUGLI311967610564661 Reconstituted Complex
SUFUGLI310899910564661 Reconstituted Complex
STK36GLI311803210806483 Affinity Capture-Western
STK36GLI310899910806483 Affinity Capture-Western
ZIC1GLI311337711238441 Affinity Capture-Western; Reconstituted Complex
ZIC1GLI310899911238441 Affinity Capture-Western; Reconstituted Complex
ZIC2GLI311337811238441 Affinity Capture-Western; Reconstituted Complex
ZIC2GLI310899911238441 Affinity Capture-Western; Reconstituted Complex
ZIC3GLI311337911238441 Reconstituted Complex
ZIC3GLI310899911238441 Reconstituted Complex
SAP18GLI311557311960000 Phenotypic Enhancement
SAP18GLI310899911960000 Phenotypic Enhancement
HDAC1GLI310931512435627 Affinity Capture-Western
HDAC1GLI310899912435627 Affinity Capture-Western
SKIGLI310899912435627 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SKIGLI311238812435627 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BTRCGLI311445716705181 Affinity Capture-Western
BTRCGLI310899916705181 Affinity Capture-Western
MED12GLI311529317000779 Reconstituted Complex; Two-hybrid
MED12GLI310899917000779 Reconstituted Complex; Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:95729
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-041111-162'