AutismKB 2.0

Annotation Details for PCLO


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Basic Information Top
Gene Symbol:PCLO ( ACZ,DKFZp779G1236 )
Gene Full Name: piccolo (presynaptic cytomatrix protein)
Band: 7q21.11
Quick LinksEntrez ID:27445; OMIM: 604918; Uniprot ID:PCLO_HUMAN; ENSEMBL ID: ENSG00000186472; HGNC ID: 13406
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005856NAS-cytoskeleton10508862
GO:0014069IEA-postsynaptic density-
GO:0016020IEA-membrane-
GO:0030054IEA-cell junction-
GO:0045202ISS-synapse-
GO:0048788TAS-cytoskeleton of presynaptic active zone15217342
GO:0070062IDA-extracellular exosome18570454
GO ID Evidence Qualifier GO_term References
GO:0005509ISS-calcium ion binding-
GO:0005522ISS-profilin binding-
GO:0005544ISS-calcium-dependent phospholipid binding-
GO ID Evidence Qualifier GO_term References
GO:0007010ISS-cytoskeleton organization-
GO:0007416IEA-synapse assembly-
GO:0016079NAS-synaptic vesicle exocytosis10508862
GO:0017157IEA-regulation of exocytosis-
GO:0019933IEA-cAMP-mediated signaling-
GO:0030073IEA-insulin secretion-
GO:0035418IEA-protein localization to synapse-
GO:0099526IEA-presynapse to nucleus signaling pathway-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
PCLOGIT211817812473661 Two-hybrid
PCLOGIT211515412473661 Two-hybrid
PCLOERC211817814734538 Affinity Capture-Western
PCLOERC211752114734538 Affinity Capture-Western
GIT1PCLO11817812473661 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
GIT1PCLO11878912473661 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1349390
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018