AutismKB 2.0

Annotation Details for GNAI1


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Basic Information Top
Gene Symbol:GNAI1 ( Gi )
Gene Full Name: guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
Band: 7q21.11
Quick LinksEntrez ID:2770; OMIM: 139310; Uniprot ID:GNAI1_HUMAN; ENSEMBL ID: ENSG00000127955; HGNC ID: 4384
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus-
GO:0005730IDA-nucleolus-
GO:0005737IDA-cytoplasm17635935
GO:0005765IDA-lysosomal membrane17897319
GO:0005813IDA-centrosome17635935
GO:0005834TAS-heterotrimeric G-protein complex3110783
GO:0005886IDA-plasma membrane17635935
GO:0005886TAS-plasma membrane-
GO:0030496IDA-midbody17635935
GO:0045121IEA-membrane raft-
GO:0070062IDA-extracellular exosome19056867
GO:0099738IDA-cell cortex region22327364
GO ID Evidence Qualifier GO_term References
GO:0000287ISS-magnesium ion binding-
GO:0001664ISS-G-protein coupled receptor binding-
GO:0003924IBA-GTPase activity-
GO:0003924ISS-GTPase activity-
GO:0003924TAS-GTPase activity-
GO:0004871IBA-signal transducer activity-
GO:0005515IPI-protein binding15537540
GO:0005525ISS-GTP binding-
GO:0005525TAS-GTP binding-
GO:0019003ISS-GDP binding-
GO:0031683IBA-G-protein beta/gamma-subunit complex binding-
GO:0031821IBA-G-protein coupled serotonin receptor binding-
GO:0032794IEA-GTPase activating protein binding-
GO ID Evidence Qualifier GO_term References
GO:0006457TAS-protein folding-
GO:0007049IEA-cell cycle-
GO:0007186ISS-G-protein coupled receptor signaling pathway-
GO:0007188IBA-adenylate cyclase-modulating G-protein coupled receptor signaling pathway-
GO:0007193TAS-adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway-
GO:0043434ISS-response to peptide hormone-
GO:0043949ISS-regulation of cAMP-mediated signaling-
GO:0050805IEA-negative regulation of synaptic transmission-
GO:0051301IMP-cell division17635935
GO:0060236IMP-regulation of mitotic spindle organization23027904
GO:1904322ISS-cellular response to forskolin-
GO:1904778IMP-positive regulation of protein localization to cell cortex22327364
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
GNAI1ADCY51066249748257 Co-purification
GNAI1ADCY51090329748257 Co-purification
GNAI1CNR110903211168387 Affinity Capture-Western
GNAI1CNR110766811168387 Affinity Capture-Western
GNAI1CRHR110903210598591 Affinity Capture-Western
GNAI1CRHR110778410598591 Affinity Capture-Western
GNAI1S1PR11090328626678 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
GNAI1S1PR11082258626678 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
GNAI1EPOR10837112538595 Reconstituted Complex
GNAI1EPOR10903212538595 Reconstituted Complex
RGS19GNAI11090328986788 10364213 Two-hybrid
RGS19GNAI11155768986788 10364213 Two-hybrid
RGS10GNAI11119339207071 Reconstituted Complex
RGS10GNAI11090329207071 Reconstituted Complex
RGS4GNAI11119319660808 Reconstituted Complex
RGS4GNAI11090329660808 Reconstituted Complex
GPR143GNAI111098910471510 Affinity Capture-Western; Reconstituted Complex
GPR143GNAI110903210471510 Affinity Capture-Western; Reconstituted Complex
IGF1RGNAI110970110644671 Affinity Capture-Western
IGF1RGNAI110903210644671 Affinity Capture-Western
RASD1GNAI110903210840027 Reconstituted Complex
RASD1GNAI111966210840027 Reconstituted Complex
RGS16GNAI111193610878019 Biochemical Activity
RGS16GNAI110903210878019 Biochemical Activity
RGS5GNAI111406211253162 Affinity Capture-Western
RGS5GNAI110903211253162 Affinity Capture-Western
RGS14GNAI110903211387333 11976690 Co-crystal Structure; Reconstituted Complex; Two-hybrid
RGS14GNAI111588011387333 11976690 Co-crystal Structure; Reconstituted Complex; Two-hybrid
RGS12GNAI111193411387333 Reconstituted Complex; Two-hybrid
RGS12GNAI110903211387333 Reconstituted Complex; Two-hybrid
RGS18GNAI110903211955952 Reconstituted Complex
RGS18GNAI112216011955952 Reconstituted Complex
RIC8AGNAI112194612509430 Reconstituted Complex; Two-hybrid
RIC8AGNAI110903212509430 Reconstituted Complex; Two-hybrid
NGBGNAI112179812860983 Reconstituted Complex
NGBGNAI110903212860983 Reconstituted Complex
GPSM1GNAI111753914530282 Reconstituted Complex
GPSM1GNAI110903214530282 Reconstituted Complex
GPSM3GNAI112200514656218 Affinity Capture-Western; Reconstituted Complex
GPSM3GNAI110903214656218 Affinity Capture-Western; Reconstituted Complex
PGRGNAI111126016484338 Affinity Capture-Western
PGRGNAI110903216484338 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:95771
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040426-1310'