AutismKB 2.0

Annotation Details for GNAO1


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Basic Information Top
Gene Symbol:GNAO1 ( DKFZp686O0962,G-ALPHA-o,GNAO )
Gene Full Name: guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
Band: 16q13
Quick LinksEntrez ID:2775; OMIM: 139311; Uniprot ID:GNAO_HUMAN; ENSEMBL ID: ENSG00000087258; HGNC ID: 4389
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005834IBA-heterotrimeric G-protein complex-
GO:0005886TAS-plasma membrane-
GO:0030425IEA-dendrite-
GO:0043209IEA-myelin sheath-
GO:0044297IEA-cell body-
GO ID Evidence Qualifier GO_term References
GO:0003924IBA-GTPase activity-
GO:0003924TAS-GTPase activity-
GO:0004871IBA-signal transducer activity-
GO:0005525TAS-GTP binding-
GO:0031683IBA-G-protein beta/gamma-subunit complex binding-
GO:0031821IBA-G-protein coupled serotonin receptor binding-
GO:0031852IBA-mu-type opioid receptor binding-
GO:0032794IEA-GTPase activating protein binding-
GO:0046872IEA-metal ion binding-
GO:0051430IBA-corticotropin-releasing hormone receptor 1 binding-
GO ID Evidence Qualifier GO_term References
GO:0006457TAS-protein folding-
GO:0006936TAS-muscle contraction9050846
GO:0007188IBA-adenylate cyclase-modulating G-protein coupled receptor signaling pathway-
GO:0007212IBA-dopamine receptor signaling pathway-
GO:0007223TAS-Wnt signaling pathway, calcium modulating pathway-
GO:0007568IEA-aging-
GO:0007626IEA-locomotory behavior-
GO:0008016IEA-regulation of heart contraction-
GO:0030900IEA-forebrain development-
GO:0031175IEA-neuron projection development-
GO:0034097IEA-response to cytokine-
GO:0042493IEA-response to drug-
GO:0042542IEA-response to hydrogen peroxide-
GO:0043278IEA-response to morphine-
GO:0043547IEA-positive regulation of GTPase activity-
GO:0051926IEA-negative regulation of calcium ion transport-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
GNAO1CACNA1B10903711395521 Reconstituted Complex
GNAO1CACNA1B10722811395521 Reconstituted Complex
GNAO1CRHR110903710598591 Affinity Capture-Western
GNAO1CRHR110778410598591 Affinity Capture-Western
OPRD1GNAO11090378393523 Affinity Capture-Western
OPRD1GNAO11110308393523 Affinity Capture-Western
OPRM1GNAO11090378393523 Affinity Capture-Western
OPRM1GNAO11110338393523 Affinity Capture-Western
RGS19GNAO11090378986788 10364213 Two-hybrid
RGS19GNAO11155768986788 10364213 Two-hybrid
RGS5GNAO11140629079700 11253162 Affinity Capture-Western; Reconstituted Complex
RGS5GNAO11090379079700 11253162 Affinity Capture-Western; Reconstituted Complex
RGS16GNAO11090379079700 Reconstituted Complex
RGS16GNAO11119369079700 Reconstituted Complex
RGS4GNAO11090379660808 Reconstituted Complex
RGS4GNAO11119319660808 Reconstituted Complex
RIC8AGNAO112194612509430 Reconstituted Complex; Two-hybrid
RIC8AGNAO110903712509430 Reconstituted Complex; Two-hybrid
NGBGNAO110903712860983 Reconstituted Complex
NGBGNAO112179812860983 Reconstituted Complex
DCTN2GNAO110903716169070 Two-hybrid
DCTN2GNAO111579416169070 Two-hybrid
RGS20GNAO110903718407463 Reconstituted Complex
RGS20GNAO111416118407463 Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
GNAO1GNAO1_129Met/Thr, GNAO1_Lys317Lys, rs1065375 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:95775
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040426-1693'