AutismKB 2.0

Annotation Details for GNAS


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Basic Information Top
Gene Symbol:GNAS ( AHO,C20orf45,GNAS1,GPSA,GSA,GSP,MGC33735,NESP,PHP1A,PHP1B,PHP1C,POH )
Gene Full Name: GNAS complex locus
Band: 20q13.32
Quick LinksEntrez ID:2778; OMIM: 139320; Uniprot ID:ALEX_HUMAN; ENSEMBL ID: ENSG00000087460,ENSG00000213705; HGNC ID: 4392
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005829IDA-cytosol12719376
GO:0005829ISS-cytosol-
GO:0005834IBA-heterotrimeric G-protein complex-
GO:0016020IDA-membrane12719376
GO:0016020ISS-membrane-
GO:0016324IEA-apical plasma membrane-
GO:0030425IEA-dendrite-
GO:0070062IDA-extracellular exosome19199708
GO ID Evidence Qualifier GO_term References
GO:0003924IBA-GTPase activity-
GO:0004871IBA-signal transducer activity-
GO:0005159IBA-insulin-like growth factor receptor binding-
GO:0005515IPI-protein binding12719376
GO:0005525IEA-GTP binding-
GO:0031683IBA-G-protein beta/gamma-subunit complex binding-
GO:0031698IBA-beta-2 adrenergic receptor binding-
GO:0031748IBA-D1 dopamine receptor binding-
GO:0031852IBA-mu-type opioid receptor binding-
GO:0035255IBA-ionotropic glutamate receptor binding-
GO:0046872IEA-metal ion binding-
GO:0051430IBA-corticotropin-releasing hormone receptor 1 binding-
GO ID Evidence Qualifier GO_term References
GO:0001894IEA-tissue homeostasis-
GO:0001958IEA-endochondral ossification-
GO:0006112IEA-energy reserve metabolic process-
GO:0006306IEA-DNA methylation-
GO:0007189IMP-adenylate cyclase-activating G-protein coupled receptor signaling pathway12719376
GO:0007191IBA-adenylate cyclase-activating dopamine receptor signaling pathway-
GO:0007606IBA-sensory perception of chemical stimulus-
GO:0035116IEA-embryonic hindlimb morphogenesis-
GO:0035264IEA-multicellular organism growth-
GO:0040032IEA-post-embryonic body morphogenesis-
GO:0042493IEA-response to drug-
GO:0045669IEA-positive regulation of osteoblast differentiation-
GO:0045672IEA-positive regulation of osteoclast differentiation-
GO:0048589IMP-developmental growth12719376
GO:0048701IEA-embryonic cranial skeleton morphogenesis-
GO:0050890IMP-cognition12719376
GO:0051216IEA-cartilage development-
GO:0060348IMP-bone development12719376
GO:0060789IMP-hair follicle placode formation12719376
GO:0070527IMP-platelet aggregation12719376
GO:0071514IEA-genetic imprinting-
GO:2000828IEA-regulation of parathyroid hormone secretion-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
GNASADCY61090409228084 Phenotypic Enhancement
GNASADCY61066259228084 Phenotypic Enhancement
GNASCRHR110904010598591 Affinity Capture-Western
GNASCRHR110778410598591 Affinity Capture-Western
GNASGNAS1090407797570 Reconstituted Complex
RGS2GNAS1090409794454 Reconstituted Complex
RGS2GNAS1119299794454 Reconstituted Complex
SNX13GNAS10904011729322 Reconstituted Complex
SNX13GNAS11677311729322 Reconstituted Complex
VIPR1GNAS10904011812005 Affinity Capture-Western
VIPR1GNAS11327411812005 Affinity Capture-Western
RIC8AGNAS12194612652642 Reconstituted Complex; Two-hybrid
RIC8AGNAS10904012652642 Reconstituted Complex; Two-hybrid
TTC1GNAS10904012748287 Affinity Capture-Western
TTC1GNAS11311612748287 Affinity Capture-Western
PAICSGNAS10904017353931 Affinity Capture-MS
PAICSGNAS11585217353931 Affinity Capture-MS
SHMT2GNAS10904017353931 Affinity Capture-MS
SHMT2GNAS11236817353931 Affinity Capture-MS
FSCN1GNAS10904017353931 Affinity Capture-MS
FSCN1GNAS11250817353931 Affinity Capture-MS
RUVBL1GNAS10904017353931 Affinity Capture-MS
RUVBL1GNAS11416617353931 Affinity Capture-MS
MDM2GNAS10904018948082 Affinity Capture-Western
MDM2GNAS11035818948082 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
GNASGNAS_T393C Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:95777
  • Data Attributes: MGI curated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-090417-2'