AutismKB 2.0

Annotation Details for GPLD1


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Basic Information Top
Gene Symbol:GPLD1 ( GPIPLD,GPIPLDM,MGC22590,PIGPLD,PIGPLD1 )
Gene Full Name: glycosylphosphatidylinositol specific phospholipase D1
Band: 6p22.3
Quick LinksEntrez ID:2822; OMIM: 602515; Uniprot ID:PHLD_HUMAN; ENSEMBL ID: ENSG00000112293; HGNC ID: 4459
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576TAS-extracellular region-
GO:0005578ISS-proteinaceous extracellular matrix-
GO:0005615IDA-extracellular space1833386
GO:0005622IDA-intracellular15907827
GO:0005737IDA-cytoplasm19135435
GO:0005737ISS-cytoplasm-
GO:0005765IDA-lysosomal membrane17897319
GO:0043231IDA-intracellular membrane-bounded organelle1833386
GO:0070062IDA-extracellular exosome23533145
GO ID Evidence Qualifier GO_term References
GO:0004621IDA-glycosylphosphatidylinositol phospholipase D activity1833386
GO:0004621TAS-glycosylphosphatidylinositol phospholipase D activity2017684
GO:0004630IDA-phospholipase D activity2760042
GO:0017080ISS-sodium channel regulator activity-
GO ID Evidence Qualifier GO_term References
GO:0001503ISS-ossification-
GO:0002042IMP-cell migration involved in sprouting angiogenesis17720976
GO:0002062ISS-chondrocyte differentiation-
GO:0002430IDA-complement receptor mediated signaling pathway15907827
GO:0006501TAS-C-terminal protein lipidation-
GO:0006507IDA-GPI anchor release2760042
GO:0006507IMP-GPI anchor release17720976
GO:0008285IDA-negative regulation of cell proliferation19135435
GO:0008286IDA-insulin receptor signaling pathway18328347
GO:0009749IDA-response to glucose15907827
GO:0010595IMP-positive regulation of endothelial cell migration17720976
GO:0010694ISS-positive regulation of alkaline phosphatase activity-
GO:0010867ISS-positive regulation of triglyceride biosynthetic process-
GO:0010897ISS-negative regulation of triglyceride catabolic process-
GO:0010907ISS-positive regulation of glucose metabolic process-
GO:0010983ISS-positive regulation of high-density lipoprotein particle clearance-
GO:0032869IDA-cellular response to insulin stimulus15907827
GO:0035690IDA-cellular response to drug17761367
GO:0035701TAS-hematopoietic stem cell migration17368745
GO:0035774ISS-positive regulation of insulin secretion involved in cellular response to glucose stimulus-
GO:0043065IDA-positive regulation of apoptotic process19135435
GO:0045919IDA-positive regulation of cytolysis15907827
GO:0046470ISS-phosphatidylcholine metabolic process-
GO:0046470TAS-phosphatidylcholine metabolic process2017684
GO:0051044IDA-positive regulation of membrane protein ectodomain proteolysis17720976
GO:0051047ISS-positive regulation of secretion-
GO:0070633ISS-transepithelial transport-
GO:0071277IDA-cellular response to calcium ion2760042
GO:0071397IMP-cellular response to cholesterol17761367
GO:0071401IMP-cellular response to triglyceride17761367
GO:0071467IDA-cellular response to pH17761367
GO:0097241TAS-hematopoietic stem cell migration to bone marrow17368745
GO:1900076IDA-regulation of cellular response to insulin stimulus18328347
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
GPLD1APOA110908311254757 Affinity Capture-Western; Reconstituted Complex
GPLD1APOA110683211254757 Affinity Capture-Western; Reconstituted Complex
GPLD1APOA410908311254757 Affinity Capture-Western; Reconstituted Complex
GPLD1APOA410683411254757 Affinity Capture-Western; Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:106604
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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