AutismKB 2.0

Annotation Details for ANGPT1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:ANGPT1 ( AGP1,AGPT,ANG1 )
Gene Full Name: angiopoietin 1
Band: 8q23.1
Quick LinksEntrez ID:284; OMIM: 601667; Uniprot ID:ANGP1_HUMAN; ENSEMBL ID: ENSG00000154188; HGNC ID: 484
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576TAS-extracellular region-
GO:0005615IDA-extracellular space8980223
GO:0005622IEA-intracellular-
GO:0005886IDA-plasma membrane19424712
GO:0005902IDA-microvillus19424712
GO:0045121IDA-membrane raft19615361
GO:0070062IDA-extracellular exosome19199708
GO ID Evidence Qualifier GO_term References
GO:0005088TAS-Ras guanyl-nucleotide exchange factor activity-
GO:0030971IPI-receptor tyrosine kinase binding8980223
GO ID Evidence Qualifier GO_term References
GO:0000165TAS-MAPK cascade-
GO:0001701IEA-in utero embryonic development-
GO:0001933IEA-negative regulation of protein phosphorylation-
GO:0001936IDANOTregulation of endothelial cell proliferation8980223
GO:0002040IDA-sprouting angiogenesis9560344
GO:0002092IDA-positive regulation of receptor internalization19424712
GO:0002740IEA-negative regulation of cytokine secretion involved in immune response-
GO:0007162IDA-negative regulation of cell adhesion19674970
GO:0007171IDA-activation of transmembrane receptor protein tyrosine kinase activity19424712
GO:0010595IDA-positive regulation of endothelial cell migration12958144
GO:0014068IEA-positive regulation of phosphatidylinositol 3-kinase signaling-
GO:0014842IDA-regulation of skeletal muscle satellite cell proliferation19733541
GO:0030097IEA-hemopoiesis-
GO:0030154IEA-cell differentiation-
GO:0030210IDA-heparin biosynthetic process19297368
GO:0031398IDA-positive regulation of protein ubiquitination19689429
GO:0031589IEA-cell-substrate adhesion-
GO:0032680IEA-regulation of tumor necrosis factor production-
GO:0033138IEA-positive regulation of peptidyl-serine phosphorylation-
GO:0034394IDA-protein localization to cell surface19615361
GO:0042308IEA-negative regulation of protein import into nucleus-
GO:0043066IDA-negative regulation of apoptotic process10218485
GO:0043116IDA-negative regulation of vascular permeability14978158
GO:0043122IEA-regulation of I-kappaB kinase/NF-kappaB signaling-
GO:0043393IEA-regulation of protein binding-
GO:0043524IEA-negative regulation of neuron apoptotic process-
GO:0043536IDA-positive regulation of blood vessel endothelial cell migration9660821
GO:0043547IEA-positive regulation of GTPase activity-
GO:0045785IEA-positive regulation of cell adhesion-
GO:0048014IDA-Tie signaling pathway19689429
GO:0050731IDA-positive regulation of peptidyl-tyrosine phosphorylation15851516
GO:0050900TAS-leukocyte migration-
GO:0050918IDA-positive chemotaxis9660821
GO:0051897IDA-positive regulation of protein kinase B signaling18425120
GO:0070374IDA-positive regulation of ERK1 and ERK2 cascade18425120
GO:0072012ISS-glomerulus vasculature development-
GO:2000352IDA-negative regulation of endothelial cell apoptotic process19674970
GO:2000446IEA-regulation of macrophage migration inhibitory factor signaling pathway-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
TEKANGPT11128698980223 9204896 9723709 12427764 Affinity Capture-Western; Reconstituted Complex
TEKANGPT11067818980223 9204896 9723709 12427764 Affinity Capture-Western; Reconstituted Complex
Gene Symbol Interactant Interaction ID References Description
TEKANGPT118496615542434 Tie2 interacts with Ang1.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:108448
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-010817-1'