AutismKB 2.0

Annotation Details for DLL1


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Basic Information Top
Gene Symbol:DLL1 ( DELTA1,DL1,Delta )
Gene Full Name: delta-like 1 (Drosophila)
Band: 6q27
Quick LinksEntrez ID:28514; OMIM: 606582; Uniprot ID:DLL1_HUMAN; ENSEMBL ID: ENSG00000198719; HGNC ID: 2908
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576NAS-extracellular region11823422
GO:0005886TAS-plasma membrane-
GO:0005887NAS-integral component of plasma membrane10079256
GO:0005912ISS-adherens junction-
GO:0016324ISS-apical plasma membrane-
GO:0031410IEA-cytoplasmic vesicle-
GO:0045121ISS-membrane raft-
GO ID Evidence Qualifier GO_term References
GO:0005112IPI-Notch binding10079256
GO:0005509IEA-calcium ion binding-
GO:0005515IPI-protein binding10079256
GO:0030957IPI-Tat protein binding15509766
GO:0097110IEA-scaffold protein binding-
GO ID Evidence Qualifier GO_term References
GO:0001709NAS-cell fate determination11581320
GO:0001756ISS-somitogenesis-
GO:0001757IEA-somite specification-
GO:0001947ISS-heart looping-
GO:0002315ISS-marginal zone B cell differentiation-
GO:0003323ISS-type B pancreatic cell development-
GO:0007219IMP-Notch signaling pathway19682396
GO:0007219ISS-Notch signaling pathway-
GO:0007219NAS-Notch signaling pathway10079256
GO:0007219TAS-Notch signaling pathway-
GO:0007220TAS-Notch receptor processing-
GO:0007368ISS-determination of left/right symmetry-
GO:0007386IEA-compartment pattern specification-
GO:0008217ISS-regulation of blood pressure-
GO:0008284ISS-positive regulation of cell proliferation-
GO:0008285ISS-negative regulation of cell proliferation-
GO:0009954ISS-proximal/distal pattern formation-
GO:0014002ISS-astrocyte development-
GO:0014807ISS-regulation of somitogenesis-
GO:0021510ISS-spinal cord development-
GO:0021688ISS-cerebellar molecular layer formation-
GO:0021693ISS-cerebellar Purkinje cell layer structural organization-
GO:0030097NAS-hemopoiesis11581320
GO:0030154TAS-cell differentiation11912004
GO:0030155TAS-regulation of cell adhesion11912004
GO:0030857ISS-negative regulation of epithelial cell differentiation-
GO:0032693IMP-negative regulation of interleukin-10 production23086448
GO:0034351ISS-negative regulation of glial cell apoptotic process-
GO:0035265ISS-organ growth-
GO:0040008ISS-regulation of growth-
GO:0045596ISS-negative regulation of cell differentiation-
GO:0045605ISS-negative regulation of epidermal cell differentiation-
GO:0045608IEA-negative regulation of auditory receptor cell differentiation-
GO:0045638IEA-negative regulation of myeloid cell differentiation-
GO:0045662ISS-negative regulation of myoblast differentiation-
GO:0045665ISS-negative regulation of neuron differentiation-
GO:0045747ISS-positive regulation of Notch signaling pathway-
GO:0045807ISS-positive regulation of endocytosis-
GO:0045944ISS-positive regulation of transcription from RNA polymerase II promoter-
GO:0046331ISS-lateral inhibition-
GO:0048630ISS-skeletal muscle tissue growth-
GO:0048631ISS-regulation of skeletal muscle tissue growth-
GO:0048633ISS-positive regulation of skeletal muscle tissue growth-
GO:0048665ISS-neuron fate specification-
GO:0048839IEA-inner ear development-
GO:0050767ISS-regulation of neurogenesis-
GO:0051302ISS-regulation of cell division-
GO:0060041ISS-retina development in camera-type eye-
GO:0060042ISS-retina morphogenesis in camera-type eye-
GO:0060853ISS-Notch signaling pathway involved in arterial endothelial cell fate commitment-
GO:0070986IEA-left/right axis specification-
GO:0072006ISS-nephron development-
GO:0072014IEA-proximal tubule development-
GO:0072070IEA-loop of Henle development-
GO:0072583ISS-clathrin-dependent endocytosis-
GO:0097102ISS-endothelial tip cell fate specification-
GO:0097150IEP-neuronal stem cell population maintenance19682396
GO:0097150ISS-neuronal stem cell population maintenance-
GO:0098773ISS-skin epidermis development-
GO:1900746ISS-regulation of vascular endothelial growth factor signaling pathway-
GO:1903672ISS-positive regulation of sprouting angiogenesis-
GO:2000505ISS-regulation of energy homeostasis-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
DLL1NOTCH111839111006133 Reconstituted Complex
DLL1NOTCH111091311006133 Reconstituted Complex
DLL1NOTCH21183919244302 10958687 11346656 Affinity Capture-Western; Reconstituted Complex
DLL1NOTCH21109159244302 10958687 11346656 Affinity Capture-Western; Reconstituted Complex
DLL1NOTCH311839111006133 Reconstituted Complex
DLL1NOTCH311091611006133 Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:104659
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-980526-29'