AutismKB 2.0

Annotation Details for CRB2


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Basic Information Top
Gene Symbol:CRB2 ( FLJ16786,FLJ38464 )
Gene Full Name: crumbs homolog 2 (Drosophila)
Band: 9q33.3
Quick LinksEntrez ID:286204; OMIM: 609720; Uniprot ID:CRUM2_HUMAN; ENSEMBL ID: ENSG00000148204; HGNC ID: 18688
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0016021IEA-integral component of membrane-
GO:0016324ISS-apical plasma membrane-
GO:0043234IDA-protein complex20299451
GO:0045121IC-membrane raft20299451
GO:0070062IDA-extracellular exosome19056867
GO ID Evidence Qualifier GO_term References
GO:0005509IEA-calcium ion binding-
GO:0019828IMPcontributes_toaspartic-type endopeptidase inhibitor activity20299451
GO:0019899IMP-enzyme binding20299451
GO ID Evidence Qualifier GO_term References
GO:0001707ISS-mesoderm formation-
GO:0001756ISS-somitogenesis-
GO:0010470ISS-regulation of gastrulation-
GO:0010718ISS-positive regulation of epithelial to mesenchymal transition-
GO:0010951IMP-negative regulation of endopeptidase activity20299451
GO:0014028ISS-notochord formation-
GO:0030513ISS-positive regulation of BMP signaling pathway-
GO:0045199ISS-maintenance of epithelial cell apical/basal polarity-
GO:0055111ISS-ingression involved in gastrulation with mouth forming second-
GO:0072358ISS-cardiovascular system development-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
CRB2CTTN13033211439336 Affinity Capture-Western
CRB2CTTN10833211439336 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
No data
No data

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018