AutismKB 2.0

Annotation Details for GRK5


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Basic Information Top
Gene Symbol:GRK5 ( FLJ39780,GPRK5 )
Gene Full Name: G protein-coupled receptor kinase 5
Band: 10q26.11
Quick LinksEntrez ID:2869; OMIM: 600870; Uniprot ID:GRK5_HUMAN; ENSEMBL ID: ENSG00000198873; HGNC ID: 4544
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005737TAS-cytoplasm7685906
GO:0005829IDA-cytosol-
GO:0005886IDA-plasma membrane14976207
GO:0005886TAS-plasma membrane-
GO:0016607IDA-nuclear speck-
GO:0031965IDA-nuclear membrane-
GO ID Evidence Qualifier GO_term References
GO:0004674IDA-protein serine/threonine kinase activity20124405
GO:0004703IEA-G-protein coupled receptor kinase activity-
GO:0005080TAS-protein kinase C binding9813065
GO:0005515IPI-protein binding17986524
GO:0005524IEA-ATP binding-
GO:0005543TAS-phospholipid binding9813065
GO:0047696IMP-beta-adrenergic receptor kinase activity20038610
GO:0047696TAS-beta-adrenergic receptor kinase activity-
GO ID Evidence Qualifier GO_term References
GO:0006915IEA-apoptotic process-
GO:0007188TAS-adenylate cyclase-modulating G-protein coupled receptor signaling pathway8626574
GO:0007217IDA-tachykinin receptor signaling pathway17986524
GO:0008277TAS-regulation of G-protein coupled receptor protein signaling pathway8288567
GO:0008284IMP-positive regulation of cell proliferation22099983
GO:0016055IEA-Wnt signaling pathway-
GO:0043066IDA-negative regulation of apoptotic process20124405
GO:0045444IEA-fat cell differentiation-
GO:0046777IDA-protein autophosphorylation14976207
GO:0051726IMP-regulation of cell cycle22099983
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
GRK5AGTR11066919211925 Affinity Capture-Western
GRK5AGTR11091279211925 Affinity Capture-Western
GRK5AVPR1A10703310858434 Affinity Capture-Western
GRK5AVPR1A10912710858434 Affinity Capture-Western
GRK5AVPR210703510858434 Affinity Capture-Western
GRK5AVPR210912710858434 Affinity Capture-Western
GRK5CALM11072529092566 Reconstituted Complex
GRK5CALM11091279092566 Reconstituted Complex
GRK5CAV110730510085129 Reconstituted Complex
GRK5CAV110912710085129 Reconstituted Complex
GRK5GRK51091278144599 Biochemical Activity
RHOGRK51119428144599 Biochemical Activity
RHOGRK51091278144599 Biochemical Activity
CABP1GRK511486310625670 Reconstituted Complex
CABP1GRK510912710625670 Reconstituted Complex
SNCBGRK511250410852916 Biochemical Activity
SNCBGRK510912710852916 Biochemical Activity
SNCAGRK511250610852916 Biochemical Activity
SNCAGRK510912710852916 Biochemical Activity
SNCGGRK510912710852916 Biochemical Activity
SNCGGRK511250710852916 Biochemical Activity
OXTRGRK511106110858434 Affinity Capture-Western
OXTRGRK510912710858434 Affinity Capture-Western
TACR1GRK511273212067742 Biochemical Activity
TACR1GRK510912712067742 Biochemical Activity
RCVRNGRK511189012507501 Affinity Capture-Western
RCVRNGRK510912712507501 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
No data
Gene Symbol Poly Names Gene overview in PDGene
GRK5rs10886424, rs11198856, rs11198907, rs11198922, rs12718341, rs1473799, rs1999628, rs2275036, rs2420616, rs291979, rs3740564, rs4752293, rs7069375, rs871196, rs884970, rs933048 Gene overview in PDGene
No data
Animal Model Top
  • MGI ID: MGI:109161
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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