AutismKB 2.0

Annotation Details for MKNK2


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Basic Information Top
Gene Symbol:MKNK2 ( GPRK7,MNK2 )
Gene Full Name: MAP kinase interacting serine/threonine kinase 2
Band: 19p13.3
Quick LinksEntrez ID:2872; OMIM: 605069; Uniprot ID:MKNK2_HUMAN; ENSEMBL ID: ENSG00000099875; HGNC ID: 7111
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IBA-nucleus-
GO:0005634IDA-nucleus-
GO:0005730IDA-nucleolus-
GO:0005737IBA-cytoplasm-
GO:0016604IDA-nuclear body-
GO:0016605IEA-PML body-
GO ID Evidence Qualifier GO_term References
GO:0004674IDA-protein serine/threonine kinase activity11463832
GO:0004683IBA-calmodulin-dependent protein kinase activity-
GO:0005515IPI-protein binding20936779
GO:0005516IBA-calmodulin binding-
GO:0005524IDA-ATP binding11463832
GO:0009931IBA-calcium-dependent protein serine/threonine kinase activity-
GO:0046872IEA-metal ion binding-
GO ID Evidence Qualifier GO_term References
GO:0006417IEA-regulation of translation-
GO:0006468IDA-protein phosphorylation11463832
GO:0007166TAS-cell surface receptor signaling pathway8415712
GO:0018105IBA-peptidyl-serine phosphorylation-
GO:0030097IDA-hemopoiesis21149447
GO:0035556IDA-intracellular signal transduction11463832
GO:0046777IBA-protein autophosphorylation-
GO:0071243IDA-cellular response to arsenic-containing substance18299328
GO:0097192IEA-extrinsic apoptotic signaling pathway in absence of ligand-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
MKNK2MAPK1410781920936779 Two-hybrid
MKNK2MAPK1410913020936779 Two-hybrid
MKNK2EIF4G110913012897141 Affinity Capture-Western; Biochemical Activity
MKNK2EIF4G110829612897141 Affinity Capture-Western; Biochemical Activity
MKNK2ESR210840411013076 Two-hybrid
MKNK2ESR210913011013076 Two-hybrid
MAPK1MKNK21115809155017 12897141 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
MAPK1MKNK21091309155017 12897141 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
RPL7AMKNK211205020936779 Two-hybrid
RPL7AMKNK210913020936779 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:894279
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030131-6099'