AutismKB 2.0

Annotation Details for GPX1


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Basic Information Top
Gene Symbol:GPX1 ( GSHPX1,MGC14399,MGC88245 )
Gene Full Name: glutathione peroxidase 1
Band: 3p21.31
Quick LinksEntrez ID:2876; OMIM: 138320; Uniprot ID:GPX1_HUMAN; ENSEMBL ID: ENSG00000233276; HGNC ID: 4553
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005737IDA-cytoplasm10833429
GO:0005739IDA-mitochondrion10833429
GO:0005759TAS-mitochondrial matrix-
GO:0005829IDA-cytosol-
GO:0005829TAS-cytosol-
GO:0070062IDA-extracellular exosome23376485
GO:0097413IDAcolocalizes_withLewy body18853169
GO ID Evidence Qualifier GO_term References
GO:0004602IDA-glutathione peroxidase activity12829378
GO:0004602TAS-glutathione peroxidase activity-
GO:0017124IPI-SH3 domain binding12893824
GO ID Evidence Qualifier GO_term References
GO:0001659IEA-temperature homeostasis-
GO:0001885IEA-endothelial cell development-
GO:0002862IEA-negative regulation of inflammatory response to antigenic stimulus-
GO:0006195TAS-purine nucleotide catabolic process-
GO:0006641IEA-triglyceride metabolic process-
GO:0006749IDA-glutathione metabolic process12829378
GO:0007605IEA-sensory perception of sound-
GO:0008631IEA-intrinsic apoptotic signaling pathway in response to oxidative stress-
GO:0009410IEA-response to xenobiotic stimulus-
GO:0009609IEA-response to symbiotic bacterium-
GO:0009650IMP-UV protection17097614
GO:0010269IMP-response to selenium ion12810669
GO:0010332IEA-response to gamma radiation-
GO:0018158IEA-protein oxidation-
GO:0019372TAS-lipoxygenase pathway-
GO:0033194IEA-response to hydroperoxide-
GO:0033599IMP-regulation of mammary gland epithelial cell proliferation16945136
GO:0034599NAS-cellular response to oxidative stress18853169
GO:0034599TAS-cellular response to oxidative stress-
GO:0040029IDA-regulation of gene expression, epigenetic16132718
GO:0042311IEA-vasodilation-
GO:0042542IMP-response to hydrogen peroxide12829378
GO:0042744IDA-hydrogen peroxide catabolic process15203190
GO:0043154IMP-negative regulation of cysteine-type endopeptidase activity involved in apoptotic process12221075
GO:0043403IEA-skeletal muscle tissue regeneration-
GO:0043523IEA-regulation of neuron apoptotic process-
GO:0043534IEA-blood vessel endothelial cell migration-
GO:0045444IEA-fat cell differentiation-
GO:0045454IDA-cell redox homeostasis12829378
GO:0048741IEA-skeletal muscle fiber development-
GO:0051450IEA-myoblast proliferation-
GO:0051702IEA-interaction with symbiont-
GO:0051897IEA-positive regulation of protein kinase B signaling-
GO:0060047IMP-heart contraction14573732
GO:0060055IEA-angiogenesis involved in wound healing-
GO:0061136IDA-regulation of proteasomal protein catabolic process12751788
GO:0090201IMP-negative regulation of release of cytochrome c from mitochondria12221075
GO:0098869IEA-cellular oxidant detoxification-
GO:1902042IMP-negative regulation of extrinsic apoptotic signaling pathway via death domain receptors12221075
GO:1902176IEA-negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway-
GO:1902905ISS-positive regulation of supramolecular fiber organization-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
GPX1ABL110654312893824 Affinity Capture-Western; Reconstituted Complex
GPX1ABL110913412893824 Affinity Capture-Western; Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
GPX1rs1050450 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:104887
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030410-1'