AutismKB 2.0

Annotation Details for ANK3


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Basic Information Top
Gene Symbol:ANK3 ( ANKYRIN-G,FLJ45464 )
Gene Full Name: ankyrin 3, node of Ranvier (ankyrin G)
Band: 10q21.2
Quick LinksEntrez ID:288; OMIM: 600465; Uniprot ID:ANK3_HUMAN; ENSEMBL ID: ENSG00000151150; HGNC ID: 494
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005764IEA-lysosome-
GO:0005783TAS-endoplasmic reticulum8666667
GO:0005794IEA-Golgi apparatus-
GO:0005829TAS-cytosol-
GO:0005886IDA-plasma membrane-
GO:0005886ISS-plasma membrane-
GO:0005923IDAcolocalizes_withbicellular tight junction14757759
GO:0009925IDAcolocalizes_withbasal plasma membrane21223964
GO:0009986ISS-cell surface21223964
GO:0014704ISS-intercalated disc-
GO:0014731ISS-spectrin-associated cytoskeleton-
GO:0016323IDA-basolateral plasma membrane15611082
GO:0016328IDA-lateral plasma membrane14757759
GO:0016529ISS-sarcoplasmic reticulum-
GO:0030018ISS-Z disc-
GO:0030315ISS-T-tubule-
GO:0030425ISS-dendrite-
GO:0031594ISS-neuromuscular junction-
GO:0033268ISS-node of Ranvier-
GO:0042383IDA-sarcolemma21223964
GO:0043005ISS-neuron projection-
GO:0043034TAS-costamere21223964
GO:0043194IDA-axon initial segment27356871
GO:0043194ISS-axon initial segment-
GO:0045211ISS-postsynaptic membrane-
GO ID Evidence Qualifier GO_term References
GO:0005200IMP-structural constituent of cytoskeleton17620337
GO:0005515IPI-protein binding15231748
GO:0008092ISS-cytoskeletal protein binding21223964
GO:0030507IBA-spectrin binding-
GO:0030507ISS-spectrin binding-
GO:0030674ISS-protein binding, bridging-
GO:0044325ISS-ion channel binding-
GO:0045296ISS-cadherin binding-
GO ID Evidence Qualifier GO_term References
GO:0000281IMP-mitotic cytokinesis14757759
GO:0006888TAS-ER to Golgi vesicle-mediated transport-
GO:0007009IMP-plasma membrane organization17620337
GO:0007016TAS-cytoskeletal anchoring at plasma membrane7836469
GO:0007165IEA-signal transduction-
GO:0007409ISS-axonogenesis-
GO:0007528ISS-neuromuscular junction development-
GO:0010628ISS-positive regulation of gene expression18180363
GO:0010650ISS-positive regulation of cell communication by electrical coupling-
GO:0010765ISS-positive regulation of sodium ion transport18180363
GO:0010960ISS-magnesium ion homeostasis-
GO:0019228ISS-neuronal action potential-
GO:0034112ISS-positive regulation of homotypic cell-cell adhesion-
GO:0043001IMP-Golgi to plasma membrane protein transport17620337
GO:0043266ISS-regulation of potassium ion transport-
GO:0045184IMP-establishment of protein localization15611082
GO:0045838ISS-positive regulation of membrane potential18180363
GO:0071286ISS-cellular response to magnesium ion-
GO:0071709IMP-membrane assembly14757759
GO:0071709ISS-membrane assembly-
GO:0072659IGI-protein localization to plasma membrane18180363
GO:0072659IMP-protein localization to plasma membrane14757759
GO:0072659ISS-protein localization to plasma membrane-
GO:0072660IGI-maintenance of protein location in plasma membrane17620337
GO:0072661IMP-protein targeting to plasma membrane17620337
GO:0090314ISS-positive regulation of protein targeting to membrane-
GO:1900827ISS-positive regulation of membrane depolarization during cardiac muscle cell action potential18180363
GO:1902260ISS-negative regulation of delayed rectifier potassium channel activity-
GO:2000651ISS-positive regulation of sodium ion transmembrane transporter activity18180363
GO:2001259ISS-positive regulation of cation channel activity-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
TIAM1ANK311293010893266 Affinity Capture-Western
TIAM1ANK310678510893266 Affinity Capture-Western
CRKLANK310778910907644 Affinity Capture-Western
CRKLANK310678510907644 Affinity Capture-Western
SPTBN4ANK312175111807096 Affinity Capture-Western
SPTBN4ANK310678511807096 Affinity Capture-Western
KCNC1ANK310994812805291 Affinity Capture-Western
KCNC1ANK310678512805291 Affinity Capture-Western
CNTN1ANK310767214761957 Affinity Capture-Western
CNTN1ANK310678514761957 Affinity Capture-Western
SCN2AANK311223114761957 Affinity Capture-Western
SCN2AANK310678514761957 Affinity Capture-Western
MAPK6ANK310678520936779 Two-hybrid
MAPK6ANK311158320936779 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
ANK3rs1551684, rs1802665, rs2279420, rs8677 Gene overview in AlzGene
No data
Gene Symbol Poly Names Gene overview in SZGene
ANK3rs10761482, rs4948410 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:88026
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-060418-1'