AutismKB 2.0

Annotation Details for GRB10


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Basic Information Top
Gene Symbol:GRB10 ( GRB-IR,Grb-10,IRBP,KIAA0207,MEG1,RSS )
Gene Full Name: growth factor receptor-bound protein 10
Band: 7p12.1
Quick LinksEntrez ID:2887; OMIM: 601523; Uniprot ID:GRB10_HUMAN; ENSEMBL ID: ENSG00000106070; HGNC ID: 4564
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005737TAS-cytoplasm9006901
GO:0005829TAS-cytosol-
GO:0005886TAS-plasma membrane9006901
GO ID Evidence Qualifier GO_term References
GO:0005070IEA-SH3/SH2 adaptor activity-
GO:0005158ISS-insulin receptor binding15664450
GO:0005515IPI-protein binding8798570
GO ID Evidence Qualifier GO_term References
GO:0007411TAS-axon guidance-
GO:0030178IDA-negative regulation of Wnt signaling pathway17376403
GO:0030949IDA-positive regulation of vascular endothelial growth factor receptor signaling pathway15060076
GO:0042326IEA-negative regulation of phosphorylation-
GO:0046325ISS-negative regulation of glucose import15664450
GO:0046627ISS-negative regulation of insulin receptor signaling pathway15664450
GO:0048009IEA-insulin-like growth factor receptor signaling pathway-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
GRB10ABL11065439006901 9747873 Affinity Capture-Western; Reconstituted Complex
GRB10ABL11091449006901 9747873 Affinity Capture-Western; Reconstituted Complex
GRB10BCR1091449747873 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
GRB10BCR1070839747873 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
GRB10EGFR1091449506989 Reconstituted Complex
GRB10EGFR1082769506989 Reconstituted Complex
GRB10EPHB11091448798570 Two-hybrid
GRB10EPHB11083618798570 Two-hybrid
GRB10FYN10914410871840 Biochemical Activity
GRB10FYN10881010871840 Biochemical Activity
GRB10GHR1091449632636 Affinity Capture-Western
GRB10GHR1089579632636 Affinity Capture-Western
INSRGRB101098547479769 8621530 9006901 9506989 10871840 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
INSRGRB101091447479769 8621530 9006901 9506989 10871840 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
RETGRB101119117665556 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
RETGRB101091447665556 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
IRS1GRB101098748621530 Reconstituted Complex
IRS1GRB101091448621530 Reconstituted Complex
IGF1RGRB101091448764099 8776723 9506989 12697834 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
IGF1RGRB101097018764099 8776723 9506989 12697834 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
RAF1GRB101118319553107 10585452 Affinity Capture-Western; Co-fractionation; Reconstituted Complex; Two-hybrid
RAF1GRB101091449553107 10585452 Affinity Capture-Western; Co-fractionation; Reconstituted Complex; Two-hybrid
MAP2K1GRB101091449553107 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
MAP2K1GRB101115909553107 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
JAK2GRB101099209632636 Affinity Capture-Western
JAK2GRB101091449632636 Affinity Capture-Western
SRCGRB1011259210871840 Biochemical Activity
SRCGRB1010914410871840 Biochemical Activity
KDRGRB1010999211494124 Two-hybrid
KDRGRB1010914411494124 Two-hybrid
KITGRB1011001511809791 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
KITGRB1010914411809791 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
GIGYF1GRB1012221812771153 Affinity Capture-Western; Two-hybrid
GIGYF1GRB1010914412771153 Affinity Capture-Western; Two-hybrid
GIGYF2GRB1011752012771153 Two-hybrid
GIGYF2GRB1010914412771153 Two-hybrid
Gene Symbol Interactant Interaction ID References Description
GRB10EGFR1837849506989 Grb10 interacts with EGFR.
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
GRB10rs4947710 Gene overview in AlzGene
No data
No data
Animal Model Top
  • MGI ID: MGI:103232
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-091020-12'