AutismKB 2.0

Annotation Details for GRIA1


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Basic Information Top
Gene Symbol:GRIA1 ( GLUH1,GLUR1,GLURA,GluA1,HBGR1,MGC133252 )
Gene Full Name: glutamate receptor, ionotropic, AMPA 1
Band: 5q33.2
Quick LinksEntrez ID:2890; OMIM: 138248; Uniprot ID:GRIA1_HUMAN; ENSEMBL ID: ENSG00000155511; HGNC ID: 4571
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000139IEA-Golgi membrane-
GO:0005789TAS-endoplasmic reticulum membrane-
GO:0005886TAS-plasma membrane-
GO:0008021IEA-synaptic vesicle-
GO:0009986ISS-cell surface-
GO:0012507TAS-ER to Golgi transport vesicle membrane-
GO:0014069ISS-postsynaptic density-
GO:0030054IEA-cell junction-
GO:0030425ISS-dendrite-
GO:0030666TAS-endocytic vesicle membrane-
GO:0032281IBA-AMPA glutamate receptor complex-
GO:0032281ISS-AMPA glutamate receptor complex-
GO:0032591IDA-dendritic spine membrane20434989
GO:0033116TAS-endoplasmic reticulum-Golgi intermediate compartment membrane-
GO:0043025ISS-neuronal cell body-
GO:0043197ISS-dendritic spine-
GO:0044308IEA-axonal spine-
GO:0044309ISS-neuron spine-
GO:0055037IDA-recycling endosome20434989
GO:0098839IEA-postsynaptic density membrane-
GO ID Evidence Qualifier GO_term References
GO:0004971IDA-AMPA glutamate receptor activity20805473
GO:0005231TAS-excitatory extracellular ligand-gated ion channel activity-
GO:0005234IEA-extracellular-glutamate-gated ion channel activity-
GO:0005515IPI-protein binding20805473
GO:0008066TAS-glutamate receptor activity1320959
GO:0030165ISS-PDZ domain binding-
GO:0099583IEA-neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration-
GO:1904315IEA-transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential-
GO ID Evidence Qualifier GO_term References
GO:0006888TAS-ER to Golgi vesicle-mediated transport-
GO:0007165TAS-signal transduction1311100
GO:0007268TAS-chemical synaptic transmission1311100
GO:0007616IEA-long-term memory-
GO:0031623IEA-receptor internalization-
GO:0034220IEA-ion transmembrane transport-
GO:0035235IEA-ionotropic glutamate receptor signaling pathway-
GO:0048208TAS-COPII vesicle coating-
GO:0060079IEA-excitatory postsynaptic potential-
GO:0060292IEA-long term synaptic depression-
GO:0099566IEA-regulation of postsynaptic cytosolic calcium ion concentration-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
GRIA1DLG11080839677374 11567040 12933808 Affinity Capture-Western; Reconstituted Complex
GRIA1DLG11091479677374 11567040 12933808 Affinity Capture-Western; Reconstituted Complex
GRIA1EPB41L110835011050113 Affinity Capture-Western
GRIA1EPB41L110914711050113 Affinity Capture-Western
GRIA1EPB41L210835111050113 Affinity Capture-Western; Two-hybrid
GRIA1EPB41L210914711050113 Affinity Capture-Western; Two-hybrid
GRIK2GRIA11091558288598 Affinity Capture-Western
GRIK2GRIA11091478288598 Affinity Capture-Western
GRIA4GRIA11091479466455 Affinity Capture-Western
GRIA4GRIA11091509466455 Affinity Capture-Western
GRIA2GRIA110914710358037 Affinity Capture-Western
GRIA2GRIA110914810358037 Affinity Capture-Western
CACNG2GRIA111564811140673 Affinity Capture-Western
CACNG2GRIA110914711140673 Affinity Capture-Western
HOMER1GRIA111484511418862 Affinity Capture-Western
HOMER1GRIA110914711418862 Affinity Capture-Western
GRIP1GRIA110914711891216 Reconstituted Complex
GRIP1GRIA111699511891216 Reconstituted Complex
SDCBPGRIA111228711891216 Reconstituted Complex
SDCBPGRIA110914711891216 Reconstituted Complex
PICK1GRIA111484911891216 Reconstituted Complex
PICK1GRIA110914711891216 Reconstituted Complex
GRID2GRIA110914712573530 Affinity Capture-Western
GRID2GRIA110915212573530 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
GRIA1rs10631988, rs1422884, rs2963944, rs2963998, rs2964018, rs3792766, rs4530817, rs707176 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:95808
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-020125-1'