AutismKB 2.0

Annotation Details for GRN


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Basic Information Top
Gene Symbol:GRN ( GEP,GP88,PCDGF,PEPI,PGRN )
Gene Full Name: granulin
Band: 17q21.31
Quick LinksEntrez ID:2896; OMIM: 138945; Uniprot ID:GRN_HUMAN; ENSEMBL ID: ENSG00000030582; HGNC ID: 4601
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576TAS-extracellular region-
GO:0005615IEA-extracellular space-
GO:0005764IDA-lysosome-
GO:0005768IDA-endosome-
GO:0005783IDA-endoplasmic reticulum-
GO:0035578TAS-azurophil granule lumen-
GO:0070062IDA-extracellular exosome23376485
GO ID Evidence Qualifier GO_term References
GO:0003723IDA-RNA binding22658674
GO:0005125IEA-cytokine activity-
GO:0005515IPI-protein binding16189514
GO:0008083TAS-growth factor activity1542665
GO ID Evidence Qualifier GO_term References
GO:0007165NAS-signal transduction1542665
GO:0043312TAS-neutrophil degranulation-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
GRNCCNT110915312588988 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
GRNCCNT110734312588988 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
GRNCDK910745912588988 Affinity Capture-Western
GRNCDK910915312588988 Affinity Capture-Western
HK3GRN10915311068878 Reconstituted Complex; Two-hybrid
HK3GRN10934811068878 Reconstituted Complex; Two-hybrid
TOP3BGRN11445211549288 Two-hybrid
TOP3BGRN10915311549288 Two-hybrid
DLK1GRN11431611846389 Two-hybrid
DLK1GRN10915311846389 Two-hybrid
SLPIGRN11247512526812 Affinity Capture-Western
SLPIGRN10915312526812 Affinity Capture-Western
TATGRN11276112588988 Affinity Capture-Western; Reconstituted Complex
TATGRN10915312588988 Affinity Capture-Western; Reconstituted Complex
HOXA1GRN10943816189514 Two-hybrid
HOXA1GRN10915316189514 Two-hybrid
FAM131CGRN13152316189514 Two-hybrid
FAM131CGRN10915316189514 Two-hybrid
TRIB3GRN12175618276110 Affinity Capture-Western; Two-hybrid
TRIB3GRN10915318276110 Affinity Capture-Western; Two-hybrid
Gene Symbol Interactant Interaction ID References Description
GRNCCNT121509112588988 Cyclin T1 interacts with granulin.
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
GRNPGRN_IVS8+7GA, rs17523519, rs34424835, rs3785817, rs3859268, rs4792939, rs5848, rs850713, rs850714, rs850737, rs9897526 Gene overview in AlzGene
Gene Symbol Poly Names Gene overview in PDGene
GRNGRN_IVS8+7G>A, rs17523519, rs34424835, rs3859268, rs5848, rs850713, rs9897526 Gene overview in PDGene
No data
Animal Model Top
  • MGI ID: MGI:95832
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030131-7393'