Gene Symbol:	GRIK2 ( EAA4,GLR6,GLUK6,GLUR6,MGC74427,MRT6 )
Gene Full Name:	glutamate receptor, ionotropic, kainate 2
Band:	6q16.3
Quick Links	Entrez ID:2898; OMIM: 138244; Uniprot ID:GRIK2_HUMAN; ENSEMBL ID: ENSG00000164418; HGNC ID: 4580
Relate to Another Database:	SFARIGene; denovo-db

GO ID	Evidence	Qualifier	GO_term	References
GO:0005886	TAS	-	plasma membrane	-
GO:0005887	TAS	-	integral component of plasma membrane	7536611
GO:0008328	IEA	-	ionotropic glutamate receptor complex	-
GO:0030054	IEA	-	cell junction	-
GO:0032839	IEA	-	dendrite cytoplasm	-
GO:0043195	IEA	-	terminal bouton	-
GO:0043204	IEA	-	perikaryon	-
GO:0045211	IEA	-	postsynaptic membrane	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0005234	IMP	-	extracellular-glutamate-gated ion channel activity	28180184
GO:0015276	TAS	-	ligand-gated ion channel activity	-
GO:0015277	IDA	-	kainate selective glutamate receptor activity	15537878
GO:0030165	IEA	-	PDZ domain binding	-
GO:0031624	IEA	-	ubiquitin conjugating enzyme binding	-
GO:0031625	IEA	-	ubiquitin protein ligase binding	-
GO:0042803	IEA	-	protein homodimerization activity	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0006810	NAS	-	transport	7536611
GO:0007215	TAS	-	glutamate receptor signaling pathway	7536611
GO:0007268	TAS	-	chemical synaptic transmission	7536611
GO:0034220	IEA	-	ion transmembrane transport	-
GO:0035235	IEA	-	ionotropic glutamate receptor signaling pathway	-
GO:0043113	IEA	-	receptor clustering	-
GO:0043525	IEA	-	positive regulation of neuron apoptotic process	-
GO:0046328	IEA	-	regulation of JNK cascade	-
GO:0048172	IMP	-	regulation of short-term neuronal synaptic plasticity	15537878
GO:0050804	IDA	-	modulation of synaptic transmission	15537878
GO:0050806	IMP	-	positive regulation of synaptic transmission	15537878
GO:0051402	IEA	-	neuron apoptotic process	-
GO:0051967	IEA	-	negative regulation of synaptic transmission, glutamatergic	-
GO:0060079	IEA	-	excitatory postsynaptic potential	-

Gene Symbol	Interactant	Interaction ID	References	Description
GRIK2	DLG1	108083	9808460 11279111	Affinity Capture-Western
GRIK2	DLG1	109155	9808460 11279111	Affinity Capture-Western
GRIK2	DLG3	108085	9808460	Affinity Capture-Western
GRIK2	DLG3	109155	9808460	Affinity Capture-Western
GRIK2	DLG4	109155	9808460 11279111 12597860	Affinity Capture-Western; Reconstituted Complex
GRIK2	DLG4	108086	9808460 11279111 12597860	Affinity Capture-Western; Reconstituted Complex
GRIK2	GRIA1	109155	8288598	Affinity Capture-Western
GRIK2	GRIA1	109147	8288598	Affinity Capture-Western
GRIK2	GRIA2	109155	8288598	Affinity Capture-Western
GRIK2	GRIA2	109148	8288598	Affinity Capture-Western
GRIK2	GRID2	109155	12573530	Affinity Capture-Western
GRIK2	GRID2	109152	12573530	Affinity Capture-Western
GRIK5	GRIK2	109155	8288598 9466455	Affinity Capture-Western
GRIK5	GRIK2	109158	8288598 9466455	Affinity Capture-Western
SDCBP	GRIK2	109155	11891216 12597860	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SDCBP	GRIK2	112287	11891216 12597860	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
GRIP1	GRIK2	109155	11891216 12597860	Reconstituted Complex
GRIP1	GRIK2	116995	11891216 12597860	Reconstituted Complex
PICK1	GRIK2	109155	12597860	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PICK1	GRIK2	114849	12597860	Affinity Capture-Western; Reconstituted Complex; Two-hybrid

AutismKB 2.0

Annotation Details for GRIK2