AutismKB 2.0

Annotation Details for HIPK2


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Basic Information Top
Gene Symbol:HIPK2 ( DKFZp686K02111,FLJ23711,PRO0593 )
Gene Full Name: homeodomain interacting protein kinase 2
Band: 7q34
Quick LinksEntrez ID:28996; OMIM: 606868; Uniprot ID:HIPK2_HUMAN; ENSEMBL ID: ENSG00000064393; HGNC ID: 14402
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus12220523
GO:0005654TAS-nucleoplasm-
GO:0005737ISS-cytoplasm-
GO:0016604IDA-nuclear body12874272
GO:0016604TAS-nuclear body14626429
GO:0016605IDAcolocalizes_withPML body14647468
GO:0090575ISS-RNA polymerase II transcription factor complex-
GO ID Evidence Qualifier GO_term References
GO:0001102ISS-RNA polymerase II activating transcription factor binding-
GO:0001105ISScontributes_toRNA polymerase II transcription coactivator activity-
GO:0003714IDA-transcription corepressor activity12874272
GO:0004672IDA-protein kinase activity19448668
GO:0004674ISS-protein serine/threonine kinase activity-
GO:0004674TAS-protein serine/threonine kinase activity-
GO:0005515IPI-protein binding12220523
GO:0005524IEA-ATP binding-
GO:0046332IPI-SMAD binding12874272
GO:0046790IPI-virion binding14990717
GO ID Evidence Qualifier GO_term References
GO:0000122IEA-negative regulation of transcription from RNA polymerase II promoter-
GO:0001654ISS-eye development20579985
GO:0006366IEA-transcription from RNA polymerase II promoter-
GO:0006468IDA-protein phosphorylation19448668
GO:0006978IDA-DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator14647468
GO:0007179IEA-transforming growth factor beta receptor signaling pathway-
GO:0007224IEA-smoothened signaling pathway-
GO:0007628IEA-adult walking behavior-
GO:0008284IEA-positive regulation of cell proliferation-
GO:0009952IEA-anterior/posterior pattern specification-
GO:0010842IEA-retina layer formation-
GO:0018105ISS-peptidyl-serine phosphorylation-
GO:0018107ISS-peptidyl-threonine phosphorylation-
GO:0019048NAS-modulation by virus of host morphology or physiology14990717
GO:0030182IEA-neuron differentiation-
GO:0030218ISS-erythrocyte differentiation20231426
GO:0030511IMP-positive regulation of transforming growth factor beta receptor signaling pathway14678985
GO:0030514IMP-negative regulation of BMP signaling pathway12874272
GO:0030578TAS-PML body organization18974774
GO:0032092ISS-positive regulation of protein binding-
GO:0042771TAS-intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator18974774
GO:0043388IEA-positive regulation of DNA binding-
GO:0043524IEA-negative regulation of neuron apoptotic process-
GO:0045766IDA-positive regulation of angiogenesis19046997
GO:0045893IMP-positive regulation of transcription, DNA-templated14647468
GO:0045944ISS-positive regulation of transcription from RNA polymerase II promoter-
GO:0046330IMP-positive regulation of JNK cascade14678985
GO:0048596IEA-embryonic camera-type eye morphogenesis-
GO:0050882IEA-voluntary musculoskeletal movement-
GO:0051091ISS-positive regulation of sequence-specific DNA binding transcription factor activity-
GO:0051726TAS-regulation of cell cycle18974774
GO:0060059IEA-embryonic retina morphogenesis in camera-type eye-
GO:0060235IEA-lens induction in camera-type eye-
GO:0060395IDA-SMAD protein signal transduction12874272
GO:0061072IEA-iris morphogenesis-
GO:0071456TAS-cellular response to hypoxia18974774
GO:0097193NAS-intrinsic apoptotic signaling pathway15122315
GO:1901796TAS-regulation of signal transduction by p53 class mediator-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
HIPK2RUNX111881516917507 Affinity Capture-Western; Biochemical Activity
HIPK2RUNX110730916917507 Affinity Capture-Western; Biochemical Activity
HIPK2CREBBP11881511740489 Affinity Capture-Western
HIPK2CREBBP10777711740489 Affinity Capture-Western
HIPK2DAXX11881514678985 Affinity Capture-Western; Reconstituted Complex
HIPK2DAXX10798514678985 Affinity Capture-Western; Reconstituted Complex
HIPK2EP30010834716917507 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
HIPK2EP30011881516917507 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
HIPK2SMAD111026112874272 Affinity Capture-Western; Reconstituted Complex
HIPK2SMAD111881512874272 Affinity Capture-Western; Reconstituted Complex
HIPK2SMAD211881512874272 Reconstituted Complex
HIPK2SMAD211026212874272 Reconstituted Complex
HIPK2SMAD311881512874272 Reconstituted Complex
HIPK2SMAD311026312874272 Reconstituted Complex
HIPK2MYB11881515082531 16055500 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
HIPK2MYB11068715082531 16055500 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
HIPK2MYBL111881516055500 Reconstituted Complex
HIPK2MYBL111068816055500 Reconstituted Complex
HIPK2MYBL211069016055500 Affinity Capture-Western
HIPK2MYBL211881516055500 Affinity Capture-Western
HIPK2SKI11881512874272 Affinity Capture-Western; Reconstituted Complex
HIPK2SKI11238812874272 Affinity Capture-Western; Reconstituted Complex
HIPK2SP10011881514647468 Affinity Capture-Western
HIPK2SP10011255514647468 Affinity Capture-Western
HIPK2MAP3K711881515082531 Biochemical Activity
HIPK2MAP3K711274815082531 Biochemical Activity
HIPK2NKX2-111881511438542 Two-hybrid
HIPK2NKX2-111293611438542 Two-hybrid
HIPK2TP5311881511740489 11925430 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
HIPK2TP5311301011740489 11925430 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
HIPK2TP7311881511925430 Two-hybrid
HIPK2TP7311301411925430 Two-hybrid
HIPK2UBE2I11317714609633 20936779 Two-hybrid
HIPK2UBE2I11881514609633 20936779 Two-hybrid
HIPK2SUMO111318814609633 Two-hybrid
HIPK2SUMO111881514609633 Two-hybrid
HIPK2CUL111403218765672 Affinity Capture-Western
HIPK2CUL111881518765672 Affinity Capture-Western
HIPK2TP6311881511925430 Two-hybrid
HIPK2TP6311418111925430 Two-hybrid
HIPK2TRADD11425711032752 Affinity Capture-Western
HIPK2TRADD11881511032752 Affinity Capture-Western
HIPK2BTRC11881518765672 Affinity Capture-Western
HIPK2BTRC11445718765672 Affinity Capture-Western
HIPK2RANBP911535912220523 Affinity Capture-Western; Two-hybrid
HIPK2RANBP911881512220523 Affinity Capture-Western; Two-hybrid
TP53INP1HIPK212515212851404 Affinity Capture-Western; Reconstituted Complex
TP53INP1HIPK211881512851404 Affinity Capture-Western; Reconstituted Complex
NLKHIPK211968515082531 Reconstituted Complex; Two-hybrid
NLKHIPK211881515082531 Reconstituted Complex; Two-hybrid
HIPK2HIPK211881516917507 Reconstituted Complex
FBXW7HIPK212058118765672 Affinity Capture-Western
FBXW7HIPK211881518765672 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-031125-4'