AutismKB 2.0

Annotation Details for GRIN1


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Basic Information Top
Gene Symbol:GRIN1 ( NMDA1,NMDAR1,NR1 )
Gene Full Name: glutamate receptor, ionotropic, N-methyl D-aspartate 1
Band: 9q34.3
Quick LinksEntrez ID:2902; OMIM: 138249; Uniprot ID:NMDZ1_HUMAN; ENSEMBL ID: ENSG00000176884; HGNC ID: 4584
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005783IEA-endoplasmic reticulum-
GO:0005886TAS-plasma membrane-
GO:0005887IDA-integral component of plasma membrane7685113
GO:0008021ISS-synaptic vesicle-
GO:0009986ISS-cell surface-
GO:0014069ISS-postsynaptic density-
GO:0017146IDA-NMDA selective glutamate receptor complex7679115
GO:0030054IEA-cell junction-
GO:0030425IDA-dendrite10749211
GO:0043005ISS-neuron projection-
GO:0043083ISS-synaptic cleft-
GO:0043195ISS-terminal bouton-
GO:0043197ISS-dendritic spine-
GO:0045202ISS-synapse-
GO:0045211ISS-postsynaptic membrane-
GO:0060076ISS-excitatory synapse-
GO:0098839IEA-postsynaptic density membrane-
GO ID Evidence Qualifier GO_term References
GO:0004972IDAcontributes_toNMDA glutamate receptor activity7679115
GO:0005088TAS-Ras guanyl-nucleotide exchange factor activity-
GO:0005102IEA-receptor binding-
GO:0005234IEA-extracellular-glutamate-gated ion channel activity-
GO:0005262IDAcontributes_tocalcium channel activity7685113
GO:0005509ISS-calcium ion binding-
GO:0005515IPI-protein binding17047094
GO:0005516ISS-calmodulin binding-
GO:0016594IDA-glycine binding7685113
GO:0016594IMP-glycine binding17047094
GO:0016595IDA-glutamate binding7685113
GO:0042165ISS-neurotransmitter binding-
GO:1904315IEA-transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential-
GO ID Evidence Qualifier GO_term References
GO:0000165TAS-MAPK cascade-
GO:0001661IEA-conditioned taste aversion-
GO:0001967IEA-suckling behavior-
GO:0001975IEA-response to amphetamine-
GO:0006812IDA-cation transport7685113
GO:0006874IEA-cellular calcium ion homeostasis-
GO:0007585IEA-respiratory gaseous exchange-
GO:0007616IEA-long-term memory-
GO:0008344IEA-adult locomotory behavior-
GO:0008355IEA-olfactory learning-
GO:0008542ISS-visual learning-
GO:0018964ISS-propylene metabolic process-
GO:0019233IEA-sensory perception of pain-
GO:0021586IEA-pons maturation-
GO:0021987IEA-cerebral cortex development-
GO:0034765IEA-regulation of ion transmembrane transport-
GO:0035176IEA-social behavior-
GO:0035235ISS-ionotropic glutamate receptor signaling pathway-
GO:0035249IEA-synaptic transmission, glutamatergic-
GO:0042391IDA-regulation of membrane potential7679115
GO:0043065IEA-positive regulation of apoptotic process-
GO:0043278IEA-response to morphine-
GO:0043524IEA-negative regulation of neuron apoptotic process-
GO:0043547IEA-positive regulation of GTPase activity-
GO:0043576IEA-regulation of respiratory gaseous exchange-
GO:0045471IDA-response to ethanol18445116
GO:0045944ISS-positive regulation of transcription from RNA polymerase II promoter-
GO:0048013TAS-ephrin receptor signaling pathway-
GO:0048169IEA-regulation of long-term neuronal synaptic plasticity-
GO:0048814IEA-regulation of dendrite morphogenesis-
GO:0050770IEA-regulation of axonogenesis-
GO:0051963IEA-regulation of synapse assembly-
GO:0055074ISS-calcium ion homeostasis-
GO:0060079ISS-excitatory postsynaptic potential-
GO:0060134IEA-prepulse inhibition-
GO:0060179IEA-male mating behavior-
GO:0070588IEA-calcium ion transmembrane transport-
GO:2000463ISS-positive regulation of excitatory postsynaptic potential-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
CACNG2GRIN111564811140673 Co-fractionation
CACNG2GRIN110915911140673 Co-fractionation
GRIN3BGRIN110915912008020 Affinity Capture-Western
GRIN3BGRIN112550912008020 Affinity Capture-Western
GRIN3AGRIN110915912391275 Affinity Capture-Western
GRIN3AGRIN112550812391275 Affinity Capture-Western
GRIN2AGRIN110915912391275 Affinity Capture-Western
GRIN2AGRIN110916012391275 Affinity Capture-Western
GRIN2BGRIN110915912391275 Affinity Capture-Western
GRIN2BGRIN110916112391275 Affinity Capture-Western
ND2GRIN110915915069201 Affinity Capture-Western
ND2GRIN111063215069201 Affinity Capture-Western
Gene Symbol Interactant Interaction ID References Description
GRIN1ACTN23155559009191 alpha-actinin-2 interacts with NR1A. This interaction was modeled on a demonstrated interaction between human alpha-actinin-2 and NR1A from an unspecified species.
TIAM1GRIN121540215721239 Tiam1 interacts with NMDA subunit NR1. This interaction was modelled on a demonstrated interaction between human Tiam1 and NR1 from an unspecified species.
GRIN2AGRIN15489511279200 NR1a interacts with NR2A.
No data
AlzGene, PDGene and SZGene Top
No data
Gene Symbol Poly Names Gene overview in PDGene
GRIN1rs2301364, rs28489906, rs4880213 Gene overview in PDGene
Gene Symbol Poly Names Gene overview in SZGene
GRIN1GRIN1_1140G/A, GRIN1_1719G/A, GRIN1_1970A/G, GRIN1_243C, GRIN1_6435G/A, GRIN1_6608A/G, GRIN1_IVS11+8A/G, GRIN1_IVS2-11G/A, GRIN1_IVS2-22T/C, GRIN1_delC/insGTAA, GRIN1_microsat, rs10747050, rs11146020, rs11146026, rs1126442, rs2301363, rs28489906, rs4880213, rs6293, rs6560665 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:95819
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-051202-1'