AutismKB 2.0

Annotation Details for GRIN2A


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Basic Information Top
Gene Symbol:GRIN2A ( NMDAR2A,NR2A )
Gene Full Name: glutamate receptor, ionotropic, N-methyl D-aspartate 2A
Band: 16p13.2
Quick LinksEntrez ID:2903; OMIM: 138253; Uniprot ID:NMDE1_HUMAN; ENSEMBL ID: ENSG00000183454; HGNC ID: 4585
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005783IEA-endoplasmic reticulum-
GO:0005886TAS-plasma membrane-
GO:0005887TAS-integral component of plasma membrane8768735
GO:0008021IEA-synaptic vesicle-
GO:0009986ISS-cell surface-
GO:0017146IDA-NMDA selective glutamate receptor complex10480938
GO:0030054IEA-cell junction-
GO:0042734IEA-presynaptic membrane-
GO:0043005IEA-neuron projection-
GO:0099061IEA-integral component of postsynaptic density membrane-
GO ID Evidence Qualifier GO_term References
GO:0004972IEA-NMDA glutamate receptor activity-
GO:0005088TAS-Ras guanyl-nucleotide exchange factor activity-
GO:0005234IEA-extracellular-glutamate-gated ion channel activity-
GO:0005262IEA-calcium channel activity-
GO:0005515IPI-protein binding11937501
GO:0008270ISS-zinc ion binding-
GO ID Evidence Qualifier GO_term References
GO:0000165TAS-MAPK cascade-
GO:0001964IEA-startle response-
GO:0001975IEA-response to amphetamine-
GO:0006810TAS-transport8768735
GO:0007215TAS-glutamate receptor signaling pathway8768735
GO:0007268TAS-chemical synaptic transmission7816096
GO:0007611TAS-learning or memory7816096
GO:0007613IEA-memory-
GO:0008104IEA-protein localization-
GO:0008542IEA-visual learning-
GO:0009611IEA-response to wounding-
GO:0019233IEA-sensory perception of pain-
GO:0022008IEA-neurogenesis-
GO:0030431IEA-sleep-
GO:0033058IEA-directional locomotion-
GO:0034765IEA-regulation of ion transmembrane transport-
GO:0035235IEA-ionotropic glutamate receptor signaling pathway-
GO:0042177IEA-negative regulation of protein catabolic process-
GO:0042417IEA-dopamine metabolic process-
GO:0042428IEA-serotonin metabolic process-
GO:0042493IEA-response to drug-
GO:0043065IEA-positive regulation of apoptotic process-
GO:0043547IEA-positive regulation of GTPase activity-
GO:0045471IDA-response to ethanol18445116
GO:0051930IEA-regulation of sensory perception of pain-
GO:0060079IEA-excitatory postsynaptic potential-
GO:0060291IEA-long-term synaptic potentiation-
GO:0070588IEA-calcium ion transmembrane transport-
GO:1900273IEA-positive regulation of long-term synaptic potentiation-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
GRIN2ADLG110808312933808 Affinity Capture-Western; Reconstituted Complex
GRIN2ADLG110916012933808 Affinity Capture-Western; Reconstituted Complex
GRIN2ADLG21080849278515 Two-hybrid
GRIN2ADLG21091609278515 Two-hybrid
GRIN2ADLG31091609278515 11937501 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
GRIN2ADLG31080859278515 11937501 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
GRIN2ADLG41091609278515 9286858 10648730 11937501 12419528 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
GRIN2ADLG41080869278515 9286858 10648730 11937501 12419528 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
GRIN2APTK2B10916011478920 12576483 Affinity Capture-Western
GRIN2APTK2B10848011478920 12576483 Affinity Capture-Western
GRIN2AFYN1088109892651 10458595 12419528 12932824 Affinity Capture-Western; Reconstituted Complex
GRIN2AFYN1091609892651 10458595 12419528 12932824 Affinity Capture-Western; Reconstituted Complex
GRIN2AGRIN110915912391275 Affinity Capture-Western
GRIN2AGRIN110916012391275 Affinity Capture-Western
DLGAP1GRIN2A1146609286858 Affinity Capture-Western
DLGAP1GRIN2A1091609286858 Affinity Capture-Western
SRCGRIN2A10916010458595 12932824 Affinity Capture-Western; Reconstituted Complex
SRCGRIN2A11259210458595 12932824 Affinity Capture-Western; Reconstituted Complex
IL16GRIN2A10981610479680 Affinity Capture-Western; Two-hybrid
IL16GRIN2A10916010479680 Affinity Capture-Western; Two-hybrid
PTPN4GRIN2A10916010748123 Affinity Capture-Western
PTPN4GRIN2A11174110748123 Affinity Capture-Western
GRIN3BGRIN2A10916012008020 Affinity Capture-Western
GRIN3BGRIN2A12550912008020 Affinity Capture-Western
Gene Symbol Interactant Interaction ID References Description
GRIN2AGRIN15489511279200 NR1a interacts with NR2A.
IL16GRIN2A18036312923170 npro-IL-16 interacts with NR2A.
No data
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
GRIN2A(GT)n, D16S407, GRIN2A_1430G/A, GRIN2A_5765C/T, rs1014531, rs3785185, rs9806806 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:95820
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-070424-129'