AutismKB 2.0

Annotation Details for GRIN2B


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Basic Information Top
Gene Symbol:GRIN2B ( MGC142178,MGC142180,NMDAR2B,NR2B,hNR3 )
Gene Full Name: glutamate receptor, ionotropic, N-methyl D-aspartate 2B
Band: 12p13.1
Quick LinksEntrez ID:2904; OMIM: 138252; Uniprot ID:NMDE2_HUMAN; ENSEMBL ID: ENSG00000150086; HGNC ID: 4586
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005622IEA-intracellular-
GO:0005886TAS-plasma membrane-
GO:0005887TAS-integral component of plasma membrane8768735
GO:0009986ISS-cell surface-
GO:0017146IDA-NMDA selective glutamate receptor complex10480938
GO:0030054IEA-cell junction-
GO:0043005ISS-neuron projection-
GO:0045211IEA-postsynaptic membrane-
GO ID Evidence Qualifier GO_term References
GO:0004972TAS-NMDA glutamate receptor activity8768735
GO:0005088TAS-Ras guanyl-nucleotide exchange factor activity-
GO:0005234IEA-extracellular-glutamate-gated ion channel activity-
GO:0005515IPI-protein binding11937501
GO:0008270ISS-zinc ion binding-
GO:0016594IDA-glycine binding17047094
GO ID Evidence Qualifier GO_term References
GO:0000165TAS-MAPK cascade-
GO:0006810TAS-transport8768735
GO:0007215TAS-glutamate receptor signaling pathway8768735
GO:0007268TAS-chemical synaptic transmission10485705
GO:0007611TAS-learning or memory10485705
GO:0034220IEA-ion transmembrane transport-
GO:0034765IEA-regulation of ion transmembrane transport-
GO:0035235IEA-ionotropic glutamate receptor signaling pathway-
GO:0043547IEA-positive regulation of GTPase activity-
GO:0045471IDA-response to ethanol18445116
GO:0048013TAS-ephrin receptor signaling pathway-
GO:0060079IEA-excitatory postsynaptic potential-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
GRIN2BACTN21091619009191 Co-fractionation; Two-hybrid
GRIN2BACTN21066039009191 Co-fractionation; Two-hybrid
GRIN2BCAMK2A10916111459059 Reconstituted Complex
GRIN2BCAMK2A10726511459059 Reconstituted Complex
GRIN2BDLG110808311997254 Affinity Capture-Western
GRIN2BDLG110916111997254 Affinity Capture-Western
GRIN2BDLG21080849278515 11997254 Affinity Capture-Western; Two-hybrid
GRIN2BDLG21091619278515 11997254 Affinity Capture-Western; Two-hybrid
GRIN2BDLG31091619278515 11937501 11997254 12738960 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
GRIN2BDLG31080859278515 11937501 11997254 12738960 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
GRIN2BDLG41091617569905 9278515 9581762 11937501 11997254 12738960 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
GRIN2BDLG41080867569905 9278515 9581762 11937501 11997254 12738960 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
GRIN2BFYN10881010458595 Reconstituted Complex
GRIN2BFYN10916110458595 Reconstituted Complex
GRIN2BGRIN110915912391275 Affinity Capture-Western
GRIN2BGRIN110916112391275 Affinity Capture-Western
LIN7BGRIN2B12207910341223 Affinity Capture-Western; Reconstituted Complex
LIN7BGRIN2B10916110341223 Affinity Capture-Western; Reconstituted Complex
LIN7AGRIN2B10916110341223 Reconstituted Complex
LIN7AGRIN2B11435210341223 Reconstituted Complex
IL16GRIN2B10981610479680 Two-hybrid
IL16GRIN2B10916110479680 Two-hybrid
ERBB2IPGRIN2B12099711278603 Reconstituted Complex
ERBB2IPGRIN2B10916111278603 Reconstituted Complex
PARK2GRIN2B11110511679592 Affinity Capture-Western
PARK2GRIN2B10916111679592 Affinity Capture-Western
GNB2L1GRIN2B11567112524444 Affinity Capture-Western
GNB2L1GRIN2B10916112524444 Affinity Capture-Western
EXOC3GRIN2B11646412738960 Affinity Capture-Western
EXOC3GRIN2B10916112738960 Affinity Capture-Western
EXOC4GRIN2B12190612738960 Affinity Capture-Western
EXOC4GRIN2B10916112738960 Affinity Capture-Western
EXOC7GRIN2B10916112738960 Reconstituted Complex
EXOC7GRIN2B11686712738960 Reconstituted Complex
ARHGAP32GRIN2B10916112857875 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
ARHGAP32GRIN2B11509112857875 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
UBCGRIN2B10916117962190 Affinity Capture-Western
UBCGRIN2B11316417962190 Affinity Capture-Western
MIB2GRIN2B12676917962190 Affinity Capture-Western; Reconstituted Complex
MIB2GRIN2B10916117962190 Affinity Capture-Western; Reconstituted Complex
KDM5BGRIN2B11598419336002 Affinity Capture-MS
KDM5BGRIN2B10916119336002 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
GRIN2BENS10557853, rs1019385, rs12368476, rs1806201, rs3764028, rs890 Gene overview in AlzGene
Gene Symbol Poly Names Gene overview in PDGene
GRIN2Brs1019385, rs1805476, rs1806201, rs7301328 Gene overview in PDGene
Gene Symbol Poly Names Gene overview in SZGene
GRIN2BGRIN2B_5041T/G, GRIN2B_5806A/C, GRIN2B_5985C/A, GRIN2B_IVS4+40A/G, rs1008619, rs1019385, rs1075010, rs1125236, rs1421104, rs1805246, rs1805247, rs1805476, rs1805480, rs1805482, rs1805490, rs1805502, rs1805539, rs1806191, rs1806201, rs1806209, rs1861786, rs1981781, rs1981782, rs2041986, rs2111511, rs219872, rs219873, rs220557, rs220599, rs2268097, rs2268099, rs2268113, rs2268114, rs2268121, rs2268122, rs2268130, rs2270359, rs2284404, rs2284407, rs2284416, rs2300234, rs2300245, rs7301328, rs890 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:95821
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-061207-27'